論文

査読有り 国際誌
2020年4月15日

Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice.

Scientific reports
  • Shunsuke Sanada
  • ,
  • Takuji Suzuki
  • ,
  • Akika Nagata
  • ,
  • Tsutomu Hashidume
  • ,
  • Yuko Yoshikawa
  • ,
  • Noriyuki Miyoshi

10
1
開始ページ
6479
終了ページ
6479
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-63627-y

It is crucial that the host and intestinal microflora interact and influence each other to maintain homeostasis and trigger pathological processes. Recent studies have shown that transplantation of the murine intestinal content to recipient germ-free mice enables transmission of the donor's phenotypes, such as low level chronic inflammation associated with lifestyle-related diseases. These findings indicate that intestinal bacteria produce some molecules to trigger pathological signals. However, fecal microbial metabolites that induce obesity and the type II diabetic phenotype have not been fully clarified. Here, we showed that the intestinal bacterial metabolite stercobilin, a pigment of feces, induced proinflammatory activities including TNF-α and IL-1β induction in mouse macrophage RAW264 cells. Proinflammatory stercobilin levels were significantly higher in ob/ob mice feces than in the feces of control C57BL/6 J mice. Moreover, in this study, we detected stercobilin in mice plasma for the first time, and the levels were higher in ob/ob mice than that of C57BL/6 J mice. Therefore, stercobilin is potentially reabsorbed, circulated through the blood system, and contributes to low level chronic inflammation in ob/ob mice. Since, stercobilin is a bioactive metabolite, it could be a potentially promising biomarker for diagnosis. Further analyses to elucidate the metabolic rate and the reabsorption mechanism of stercobilin may provide possible therapeutic and preventive targets.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-63627-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32296105
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160104
ID情報
  • DOI : 10.1038/s41598-020-63627-y
  • PubMed ID : 32296105
  • PubMed Central 記事ID : PMC7160104

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