論文

国際誌
2021年8月24日

Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.

BMC microbiology
  • Yuta Tsunematsu
  • ,
  • Koji Hosomi
  • ,
  • Jun Kunisawa
  • ,
  • Michio Sato
  • ,
  • Noriko Shibuya
  • ,
  • Emiko Saito
  • ,
  • Haruka Murakami
  • ,
  • Yuko Yoshikawa
  • ,
  • Yuji Iwashita
  • ,
  • Noriyuki Miyoshi
  • ,
  • Michihiro Mutoh
  • ,
  • Hideki Ishikawa
  • ,
  • Haruhiko Sugimura
  • ,
  • Motohiko Miyachi
  • ,
  • Keiji Wakabayashi
  • ,
  • Kenji Watanabe

21
1
開始ページ
235
終了ページ
235
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12866-021-02292-1

BACKGROUND: The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route of the clb + strain remains poorly characterized. RESULTS: We examined infants and their treatments during and post-birth periods to examine potential transmission of colibactin-positive E. coli to infants. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding, but not through food intake. CONCLUSIONS: Our finding suggests that transmission of colibactin-positive E. coli appears to be occurring at the very early stage of life of the newborn and hints at the possibility of developing early preventive measures against colorectal cancer.

リンク情報
DOI
https://doi.org/10.1186/s12866-021-02292-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34429063
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386082
ID情報
  • DOI : 10.1186/s12866-021-02292-1
  • PubMed ID : 34429063
  • PubMed Central 記事ID : PMC8386082

エクスポート
BibTeX RIS