論文

査読有り 国際誌
2017年

Helicobacter pylori virulence genes of minor ethnic groups in North Thailand.

Gut pathogens
  • Phawinee Subsomwong
  • ,
  • Muhammad Miftahussurur
  • ,
  • Ratha-Korn Vilaichone
  • ,
  • Thawee Ratanachu-Ek
  • ,
  • Rumiko Suzuki
  • ,
  • Junko Akada
  • ,
  • Tomohisa Uchida
  • ,
  • Varocha Mahachai
  • ,
  • Yoshio Yamaoka

9
開始ページ
56
終了ページ
56
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13099-017-0205-x

BACKGROUND: There are few studies analyzed concurrently the prevalence and genotypes of Helicobacter pylori infection with the ancestor origins from different ethnics, especially with including minority groups. We recruited a total of 289 patients in MaeSot, Thailand (154 Thai, 14 Thai-Chinese, 29 Karen and 92 Hmong ethnics). The virulence genes and genealogy of the strains were determined by PCR-based sequencing. RESULTS: Based on culture and histology/immunohistochemistry, the prevalence of H. pylori infection was 54.5% (158/289). Among 152 isolates cultured, the East-Asian-type cagA was predominant genotype among strains from Hmong, Thai-Chinese and Thai (96.0% [48/50], 85.7% [6/7] and 62.7% [47/75], respectively), whilst majority of strains from Karen had Western-type cagA (73.3% [11/15]). Patients infected with the East-Asian-type cagA strains had significantly higher activity and intestinal metaplasia in the antrum and activity in the corpus than those with Western-type cagA (P = 0.024, 0.006 and 0.005, respectively). The multilocus sequencing typing analysis discriminated that most strains from Hmong and Thai-Chinese belonged to hspEAsia (92.0 and 85.7%, respectively), whereas strains from Karen predominantly possessed hpAsia2 (86.7%) and strains from Thai were classified into hspEAsia (45.2%) and hpAsia2 (31.1%). CONCLUSIONS: Helicobacter pylori genotypes were relatively different among ethnic groups in Thailand and were associated with the source of ancestor even living in a small rural town. Caution and careful check-up are required especially on Hmong ethnic associated with high prevalence of virulence genotypes of H. pylori.

リンク情報
DOI
https://doi.org/10.1186/s13099-017-0205-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29046726
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637267
ID情報
  • DOI : 10.1186/s13099-017-0205-x
  • PubMed ID : 29046726
  • PubMed Central 記事ID : PMC5637267

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