2015年8月
Rotigotine Transdermal Patch Improves Swallowing in Dysphagic Patients with Parkinson's Disease
DYSPHAGIA
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- 巻
- 30
- 号
- 4
- 開始ページ
- 452
- 終了ページ
- 456
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00455-015-9622-5
- 出版者・発行元
- SPRINGER
Abnormal swallowing, dysphagia, is a potentially fatal symptom in Parkinson's disease (PD) and is characterized by frequent silent aspiration, an unrecognized risk of suffocation and aspiration pneumonia. Several studies have reported that the injection of apomorphine, a dopamine agonist, alleviated dysphagia in some patients with PD. The effects of other antiparkinson medications against dysphagia remain controversial. Rotigotine is another dopamine agonist with non-oral administration, i.e., a transdermal patch. Its noninvasiveness seems to render this medicine even more suitable than apomorphine for dysphasic patients. However, no direct evidence has been reported. In the present retrospective open-label study, we for the first time objectively showed that rotigotine improved swallowing on videofluoroscopic examination in dysphagic patients with PD.
- リンク情報
- ID情報
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- DOI : 10.1007/s00455-015-9622-5
- ISSN : 0179-051X
- eISSN : 1432-0460
- PubMed ID : 25966655
- Web of Science ID : WOS:000358190800009