論文

査読有り
2015年8月

Rotigotine Transdermal Patch Improves Swallowing in Dysphagic Patients with Parkinson's Disease

DYSPHAGIA
  • Makito Hirano
  • ,
  • Chiharu Isono
  • ,
  • Hikaru Sakamoto
  • ,
  • Shuichi Ueno
  • ,
  • Susumu Kusunoki
  • ,
  • Yusaku Nakamura

30
4
開始ページ
452
終了ページ
456
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00455-015-9622-5
出版者・発行元
SPRINGER

Abnormal swallowing, dysphagia, is a potentially fatal symptom in Parkinson's disease (PD) and is characterized by frequent silent aspiration, an unrecognized risk of suffocation and aspiration pneumonia. Several studies have reported that the injection of apomorphine, a dopamine agonist, alleviated dysphagia in some patients with PD. The effects of other antiparkinson medications against dysphagia remain controversial. Rotigotine is another dopamine agonist with non-oral administration, i.e., a transdermal patch. Its noninvasiveness seems to render this medicine even more suitable than apomorphine for dysphasic patients. However, no direct evidence has been reported. In the present retrospective open-label study, we for the first time objectively showed that rotigotine improved swallowing on videofluoroscopic examination in dysphagic patients with PD.

リンク情報
DOI
https://doi.org/10.1007/s00455-015-9622-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25966655
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000358190800009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00455-015-9622-5
  • ISSN : 0179-051X
  • eISSN : 1432-0460
  • PubMed ID : 25966655
  • Web of Science ID : WOS:000358190800009

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