2009年11月
Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis
CELL
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- 巻
- 139
- 号
- 5
- 開始ページ
- 907
- 終了ページ
- 919
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cell.2009.10.039
- 出版者・発行元
- CELL PRESS
During meiosis, each chromosome must pair with its unique homologous partner, a process that usually culminates with the formation of the synaptonemal complex (SC). In the nematode Caenorhabditis elegans, special regions on each chromosome known as pairing centers are essential for both homologous pairing and synapsis. We report that during early meiosis, pairing centers establish transient connections to the cytoplasmic microtubule network. These connections through the intact nuclear envelope require the SUN/KASH domain protein pair SUN-1 and ZYG-12. Disruption of microtubules inhibits chromosome pairing, indicating that these connections promote interhomolog interactions. Dynein activity is essential to license formation of the SC once pairing has been accomplished, most likely by overcoming a barrier imposed by the chromosome-nuclear envelope connection. Our findings thus provide insight into how homolog pairing is accomplished in meiosis and into the mechanisms regulating synapsis so that it occurs selectively between homologs.
For a video summary of this article, see the PaperFlick file with the Supplemental Data available online.
For a video summary of this article, see the PaperFlick file with the Supplemental Data available online.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.cell.2009.10.039
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000272169400015&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-70450221490&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-5320-6024
- ID情報
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- DOI : 10.1016/j.cell.2009.10.039
- ISSN : 0092-8674
- ORCIDのPut Code : 8792690
- Web of Science ID : WOS:000272169400015