2021年12月
Stomach secretes estrogen in response to the blood triglyceride levels
Communications Biology
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- ,
- ,
- 巻
- 4
- 号
- 1
- 開始ページ
- 1364
- 終了ページ
- 1364
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s42003-021-02901-9
- 出版者・発行元
- Springer Science and Business Media LLC
<title>Abstract</title>Mammals receive body energy information to maintain energy homeostasis. Ghrelin, insulin, leptin and vagal afferents transmit the status of fasting, blood glucose, body fat, and food intake, respectively. Estrogen also inhibits feeding behavior and lipogenesis, but increases body fat mass. However, how blood triglyceride levels are monitored and the physiological roles of estrogen from the perspective of lipid homeostasis remain unsettled. Here, we show that stomach secretes estrogen in response to the blood triglyceride levels. Estrogen-secreting gastric parietal cells predominantly use fatty acids as an energy source. Blood estrogen levels increase as blood triglyceride levels rise in a stomach-dependent manner. Estrogen levels in stomach tissues increase as blood triglyceride levels rise, and isolated gastric gland epithelium produces estrogen in a fatty acid-dependent manner. We therefore propose that stomach monitors and controls blood triglyceride levels using estrogen, which inhibits feeding behavior and lipogenesis, and promotes triglyceride uptake by adipocytes.
- リンク情報
- ID情報
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- DOI : 10.1038/s42003-021-02901-9
- eISSN : 2399-3642
- PubMed ID : 34876651
- PubMed Central 記事ID : PMC8651635