The Spontaneously Diabetic Torii (SDT) rat is a non-obese diabetic model showing various metabolic abnormalities in pre-diabetic stage. In this study, researchers investigated the pancreatic function at young ages, 5 and 7 weeks. At 5 weeks, SDT rats showed glucose intolerance and reduction of Homeostasis Model Assessment (HOMA)-pJ. At 7 weeks, the insulin content in pancreas was also decreased. Insulinogemc index showed no change at 5 and 7 weeks of age. In conclusion, the pancreatic function in SDT rats was decreased from a young age after weaning and the rat is a useful Animal Model to examine the pafhophysiological features of Impaired Glucose Tolerance (IGT). © Medwell Journals, 2012.