論文

国際誌
2022年11月

FcγRIIB inhibits inflammation in a murine model of psoriasis.

Journal of dermatological science
  • Irisu Nakabori
  • Yasuhito Hamaguchi
  • Kaori Sawada
  • Motoki Horii
  • Natsumi Fushida
  • Tasuku Kitano
  • Wang Chenyang
  • Jia Xibei
  • Yuichi Ikawa
  • Akito Komuro
  • Takashi Matsushita
  • 全て表示

108
2
開始ページ
87
終了ページ
97
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jdermsci.2022.12.003

BACKGROUND: Psoriasis is a chronic, inflammatory cutaneous disease. FcγRIIB is a low-affinity receptor for the IgG Fc fragment that provides a negative feedback pathway to down-regulate B-cell antigen receptor signaling. OBJECTIVE: The aim of this study was to investigate the role of FcγRIIB in the development of murine imiquimod (IMQ)-induced, psoriasis-like skin inflammation. METHODS: The experimental psoriasis-like skin inflammation was induced by the topical application of IMQ to the ears of FcγRIIB deficient (FcγRIIB-/-) and wild-type (WT) mice. After 6 days, epidermal thickness and inflammatory cell infiltration of the skin were histopathologically assessed and cytokine and chemokine expression levels were measured with RT-PCR. RESULTS: Skin inflammation was significantly worse in FcγRIIB-/- mice than WT mice. In the skin, the numbers of Gr-1+ neutrophils, CD11c+ dendritic cells, and Foxp3+ T cells were significantly higher in FcγRIIB-/- mice than WT mice. In the spleen, the numbers of CD25+Foxp3+ T cells and CD19+IL-10+ B cells were also significantly higher in FcγRIIB-/-mice than WT mice. The mRNA expression of Il-6, Il-17a, and Il-23a was significantly enhanced in FcγRIIB-/- mice. An adoptive transfer of splenic leukocytes from FcγRIIB-/- mice into WT mice also exacerbated skin inflammation compared to WT mice that received splenic leukocytes from WT mice. Intravenous immunoglobulin significantly reduced skin inflammation in WT mice, but this improvement was not observed in FcγRIIB-/- mice. CONCLUSION: These results indicate that FcγRIIB likely plays a suppressive role in IMQ-induced, psoriasis-like skin inflammation. Furthermore, signal modulation via FcγRIIB is a potential therapeutic target for psoriasis.

リンク情報
DOI
https://doi.org/10.1016/j.jdermsci.2022.12.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36567222
ID情報
  • DOI : 10.1016/j.jdermsci.2022.12.003
  • PubMed ID : 36567222

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