論文

査読有り
2017年11月

Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
  • Manabu Kubota
  • ,
  • Tomohisa Nagashima
  • ,
  • Harumasa Takano
  • ,
  • Fumitoshi Kodaka
  • ,
  • Hironobu Fujiwara
  • ,
  • Keisuke Takahata
  • ,
  • Sho Moriguchi
  • ,
  • Yasuyuki Kimura
  • ,
  • Makoto Higuchi
  • ,
  • Yoshiro Okubo
  • ,
  • Hidehiko Takahashi
  • ,
  • Hiroshi Ito
  • ,
  • Tetsuya Suhara

20
11
開始ページ
928
終了ページ
935
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/ijnp/pyx063
出版者・発行元
OXFORD UNIV PRESS

Background: Dopamine D2 receptors are reported to have high-affinity (D2(High)) and low-affinity (D2(Low)) states. Although an increased proportion of D2(High) has been demonstrated in animal models of schizophrenia, few clinical studies have investigated this alteration of D2(High) in schizophrenia in vivo.
Methods: Eleven patients with schizophrenia, including 10 antipsychotic-naive and 1 antipsychotic-free individuals, and 17 healthy controls were investigated. Psychopathology was assessed by Positive and Negative Syndrome Scale, and a 5-factor model was used. Two radioligands, [C-11] raclopride and [C-11] MNPA, were employed to quantify total dopamine D2 receptor and D2High, respectively, in the striatum by measuring their binding potentials. Binding potential values of [11C] raclopride and [C-11] MNPA and the binding potential ratio of [C-11] MNPA to [C-11] raclopride in the striatal subregions were statistically compared between the 2 diagnostic groups using multivariate analysis of covariance controlling for age, gender, and smoking. Correlations between binding potential and Positive and Negative Syndrome Scale scores were also examined.
Results: Multivariate analysis of covariance demonstrated a significant effect of diagnosis (schizophrenia and control) on the binding potential ratio (P = .018), although the effects of diagnosis on binding potential values obtained with either [11C] raclopride or [C-11] MNPA were nonsignificant. Posthoc test showed that the binding potential ratio was significantly higher in the putamen of patients (P = .017). The Positive and Negative Syndrome Scale "depressed" factor in patients was positively correlated with binding potential values of both ligands in the caudate.
Conclusions: The present study indicates the possibilities of: (1) a higher proportion of D2(High) in the putamen despite unaltered amounts of total dopamine D2 receptors; and (2) associations between depressive symptoms and amounts of caudate dopamine D2 receptors in patients with schizophrenia.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1093/ijnp/pyx063
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29016872
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000416724200008&DestApp=WOS_CPL