2005年10月10日
Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.
The Journal of cell biology
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- 巻
- 171
- 号
- 1
- 開始ページ
- 165
- 終了ページ
- 73
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1083/jcb.200501090
Immunoglobulin-like Necl-5/Tage4/poliovirus receptor (PVR)/CD155, originally identified as the PVR, has been shown to be up-regulated in cancer cells and to enhance growth factor-induced cell movement and proliferation. In addition, Necl-5 heterophilically trans-interacts with nectin-3, a cell-cell adhesion molecule known to form adherens junctions in cooperation with cadherin. We show here that Necl-5 was down-regulated from cell surface upon cell-cell contacts in NIH3T3 cells. This down-regulation of Necl-5 was initiated by its interaction with nectin-3 and was mainly mediated by clathrin-dependent endocytosis. Then, the down-regulation of Necl-5 induced in this way reduced movement and proliferation of NIH3T3 cells. These results indicate that the down-regulation of Necl-5 induced by its interaction with nectin-3 upon cell-cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation.
- リンク情報
- ID情報
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- DOI : 10.1083/jcb.200501090
- ISSN : 0021-9525
- J-Global ID : 200902267357813563
- PubMed ID : 16216929
- PubMed Central 記事ID : PMC2171219