Tadashi Nakaya

Profile Information

Affiliation: 講師, 福岡薬学部, 国際医療福祉大学

Degree: 博士（薬学）(東京大学)

J-GLOBAL ID: 201501049907265832
researchmap Member ID: B000246058

External link: https://kaken.nii.ac.jp/d/r/50374559.ja.html

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2020 - Present

International University of Health and Welfare
Oct, 2013 - Mar, 2020

Hokkaido University

Papers

Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.

Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki

Neurobiology of aging, 123 63-74, Mar, 2023 Peer-reviewed
A specific gene-splicing alteration in the SNRNP70 gene as a hallmark of an ALS subtype

Tadashi Nakaya

Gene, 818 146203-146203, Apr, 2022 Peer-reviewedLead authorLast authorCorresponding author
Cytoplasmic granule formation by FUS‐R495X is attributable to arginine methylation in all Gly‐rich, RGG1 and RGG2 domains

Daiki Kawahara, Toshiharu Suzuki, Tadashi Nakaya

Genes to Cells, 26(3) 190-197, Mar, 2021 Peer-reviewedLast authorCorresponding author
Dissection of FUS domains involved in regulation of SnRNP70 gene expression

Tadashi Nakaya

FEBS Letters, 594(21) 3518-3529, Nov, 2020 Peer-reviewedLead authorLast authorCorresponding author
Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.

Saori Hata, Anqi Hu, Yi Piao, Tadashi Nakaya, Hidenori Taru, Maho Morishima-Kawashima, Shigeo Murayama, Masaki Nishimura, Toshiharu Suzuki

Human molecular genetics, 29(3) 382-393, Feb 1, 2020 Peer-reviewed
Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain.

Takaya Shiraishi, Masahiro Sakaitani, Satoko Otsuguro, Katsumi Maenaka, Toshiharu Suzuki, Tadashi Nakaya

International journal of molecular medicine, 44(4) 1574-1584, Oct, 2019 Peer-reviewed
X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors.

Rika Motodate, Haruka Saito, Yuriko Sobu, Saori Hata, Yuhki Saito, Tadashi Nakaya, Toshiharu Suzuki

Journal of neurochemistry, 148(4) 480-498, Feb, 2019 Peer-reviewed
Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.

Saori Hata, Chiori Omori, Ayano Kimura, Haruka Saito, Nobuyuki Kimura, Veer Gupta, Steve Pedrini, Eugene Hone, Pratishtha Chatterjee, Kevin Taddei, Kensaku Kasuga, Takeshi Ikeuchi, Masaaki Waragai, Masaki Nishimura, Anqi Hu, Tadashi Nakaya, Laurent Meijer, Masahiro Maeda, Tohru Yamamoto, Colin L Masters, Chris C Rowe, David Ames, Kazuo Yamamoto, Ralph N Martins, Sam Gandy, Toshiharu Suzuki

Alzheimer's & dementia (New York, N. Y.), 5 740-750, 2019 Peer-reviewed
Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity.

Tadashi Nakaya, Manolis Maragkakis

Scientific reports, 8(1) 15575-15575, Oct 22, 2018 Peer-reviewed
The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1.

Maoko Tsukamoto, Kyoko Chiba, Yuriko Sobu, Yuzuha Shiraki, Yuka Okumura, Saori Hata, Akira Kitamura, Tadashi Nakaya, Seiichi Uchida, Masataka Kinjo, Hidenori Taru, Toshiharu Suzuki

FEBS letters, 592(16) 2716-2724, Aug, 2018 Peer-reviewed
Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.

Kyoko Chiba, Ko-Yi Chien, Yuriko Sobu, Saori Hata, Shun Kato, Tadashi Nakaya, Yasushi Okada, Angus C Nairn, Masataka Kinjo, Hidenori Taru, Rong Wang, Toshiharu Suzuki

Molecular biology of the cell, 28(26) 3857-3869, Dec 15, 2017 Peer-reviewed
Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease.

Chiori Omori, Rika Motodate, Yuzuha Shiraki, Kyoko Chiba, Yuriko Sobu, Ayano Kimura, Tadashi Nakaya, Hikaru Kondo, Satoshi Kurumiya, Toru Tanaka, Kazuo Yamamoto, Motowo Nakajima, Toshiharu Suzuki, Saori Hata

Nutritional neuroscience, 20(9) 538-546, Nov, 2017 Peer-reviewed
CLIPSeqTools--a novel bioinformatics CLIP-seq analysis suite.

Manolis Maragkakis, Panagiotis Alexiou, Tadashi Nakaya, Zissimos Mourelatos

RNA (New York, N.Y.), 22(1) 1-9, Jan, 2016 Peer-reviewed
Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.

Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki

The Journal of biological chemistry, 290(2) 987-95, Jan 9, 2015 Peer-reviewed
Brain aging as a cause of alzheimer’s disease

Toshiharu Suzuki, Ayano Kimura, Kyoko Chiba, Tadashi Nakaya, Saori Hata

Aging Mechanisms: Longevity, Metabolism, and Brain Aging, 305-318, Jan 1, 2015 Peer-reviewed
Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport.

Kyoko Chiba, Masahiko Araseki, Keisuke Nozawa, Keiko Furukori, Yoichi Araki, Takahide Matsushima, Tadashi Nakaya, Saori Hata, Yuhki Saito, Seiichi Uchida, Yasushi Okada, Angus C Nairn, Roger J Davis, Tohru Yamamoto, Masataka Kinjo, Hidenori Taru, Toshiharu Suzuki

Molecular biology of the cell, 25(22) 3569-80, Nov 5, 2014 Peer-reviewed
Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.

Chiori Omori, Madoka Kaneko, Etsuko Nakajima, Hiroyasu Akatsu, Masaaki Waragai, Masahiro Maeda, Maho Morishima-Kawashima, Yuhki Saito, Tadashi Nakaya, Hidenori Taru, Tohru Yamamoto, Takashi Asada, Saori Hata, Toshiharu Suzuki

Journal of Alzheimer's disease : JAD, 39(4) 861-70, 2014 Peer-reviewed
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.

Tadashi Nakaya, Panagiotis Alexiou, Manolis Maragkakis, Alexandra Chang, Zissimos Mourelatos

RNA (New York, N.Y.), 19(4) 498-509, Apr, 2013 Peer-reviewed
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Julien Couthouis, Michael P Hart, Renske Erion, Oliver D King, Zamia Diaz, Tadashi Nakaya, Fadia Ibrahim, Hyung-Jun Kim, Jelena Mojsilovic-Petrovic, Saarene Panossian, Cecilia E Kim, Edward C Frackelton, Jennifer A Solski, Kelly L Williams, Dana Clay-Falcone, Lauren Elman, Leo McCluskey, Robert Greene, Hakon Hakonarson, Robert G Kalb, Virginia M Y Lee, John Q Trojanowski, Garth A Nicholson, Ian P Blair, Nancy M Bonini, Vivianna M Van Deerlin, Zissimos Mourelatos, James Shorter, Aaron D Gitler

Human molecular genetics, 21(13) 2899-911, Jul 1, 2012 Peer-reviewed
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.

Takahide Matsushima, Yuhki Saito, James I Elliott, Kanae Iijima-Ando, Masaki Nishimura, Nobuyuki Kimura, Saori Hata, Tohru Yamamoto, Tadashi Nakaya, Toshiharu Suzuki

The Journal of biological chemistry, 287(23) 19715-24, Jun 1, 2012 Peer-reviewed

Misc.

X11-likeはLrp8の細胞内輸送を介してApoEの取り込みを制御する

本田恵子, 豊田めぐみ, 郭家伶, 中矢正, 鈴木利治

日本生化学会大会プログラム・講演要旨集, 92回 [1P-325], Sep, 2019
Alcadeinβの神経系特異的な遺伝子発現制御機構の解明

白石昂也, 中矢正, 鈴木利治

日本薬学会年会要旨集, 139年会(3) 142-142, Mar, 2019
細胞内アダプター分子X11Lを介したApoE4による細胞内情報伝達機構の解明

郭家伶, 豊田めぐみ, 中矢正, 道川誠, 鈴木利治

Dementia Japan, 32(3) 427-427, Sep, 2018
新規Notch signaling阻害剤NSI‐1の開発

白石昂也, 堺谷政弘, 乙黒聡子, 前仲勝実, 前仲勝実, 中矢正, 鈴木利治

日本薬学会年会要旨集(CD-ROM), 138th(3) ROMBUNNO.26PA‐am139S-128, Mar, 2018
新規Notch signaling阻害剤NSI-1の開発

白石昂也, 堺谷政弘, 乙黒聡子, 前仲勝実, 中矢正, 鈴木利治

日本薬学会年会要旨集, 138年会(3) 128-128, Mar, 2018
【認知症発症前治療のために解明すべき分子病態は何か?】(第2章)アルツハイマー病病因分子と制御 APPの代謝と軸索輸送における生理機能

鈴木利治, 中矢正

実験医学, 35(12) 1986-1990, Aug, 2017
ApoE4存在下でのX11L下流遺伝子発現変化

豊田めぐみ, 羽田沙緒里, 道川誠, 中矢正, 鈴木利治

Dementia Japan, 30(4) 595-595, Oct, 2016
FUS R495X凝集体形成メカニズムの解明

河原大貴, 中矢正, 鈴木利治

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [1P1229]-[1P1229], Dec, 2015
Alcadeinのγセクレターゼ代謝産物p3-Alcの血中からの抽出と定量

今野禎子, 羽田沙緒里, 中矢正, 濱田由紀子, 前田雅弘, 桑野良三, 赤津裕康, 鈴木利治

Dementia Japan, 24(3) 388-388, Sep, 2010
Alcadein代謝産物p3-A1cの血中測定

今野禎子, 羽田沙緒里, 中矢正, 武井則雄, 濱田由紀子, 前田雅弘, 鈴木利治

Dementia Japan, 23(2) 201-201, Aug, 2009
APP Thr668のリン酸化の機能解析

松島隆英, 中矢正, 鈴木利治

Dementia Japan, 22(2) 132-132, Aug, 2008
細胞ストレス依存的なFE65の核内移行機構の解析

中矢正, 河合智子, 鈴木利治

日本薬学会年会要旨集, 128年会(3) 93-93, Mar, 2008
【神経系とregulated intramembrane proteolysis】神経系におけるregulated intramembrane proteolysis

中矢正, 鈴木利治

Cognition and Dementia, 7(1) 8-13, Jan, 2008
APPの機能と代謝 (第1土曜特集 Alzheimer病--基礎・臨床研究の最新動向) -- (基礎研究)

中矢正, 鈴木利治

医学のあゆみ, 220(5) 349-353, Feb 3, 2007
The roles of X11 and X11L in APP metabolism

Yuhki Saito, Yoshitake Sano, Tadashi Nakaya, Shigeyoshi Itohara, Toshiharu Suzuki

NEUROSCIENCE RESEARCH, 58 S117-S117, 2007
X11-like protein regulates metabolism of APP in the mouse brain

Yoshitake Sano, Tadashi Nakaya, Shigeyoshi Itohara, Toshiharu Suzuki

NEUROSCIENCE RESEARCH, 55 S102-S102, 2006
2SE05 Analysis of novel functions of cleaved fragments from type l transmembrane proteins

Nakaya T, Suzuki T

Biophysics, 45(1) S24, Oct 19, 2005
Alcadein代謝産物β-Alcαの性状解析とアルツハイマー病診断マーカーとしての可能性の検証

鈴木利治, 荒木陽一, 川口映子, 浦上克哉, 西村正樹, 藤重沙弥香, 石川貴雄, 中矢正

Dementia Japan, 19(2) 144-144, Aug, 2005
昆虫を利用した創薬および病態モデルの開発アルツハイマー病新規診断マーカー前駆体タンパク質の機能ショウジョウバエを用いた解析

鈴木利治, 荒木陽一, 中矢正, 山本融, 松野健治

日本薬学会年会要旨集, 125年会(1) 258-258, Mar, 2005
アミロイド前駆体蛋白質(APP)のリン酸化を介したシナプス可塑性制御 APPの受容体仮説の検証

糸原重美, 関健二郎, 武田志津, 中矢正, 佐野良威, 鈴木利治

日本獣医学会学術集会講演要旨集, 139回 224-224, Mar, 2005

Professional Memberships

Research Projects

ALS原因因子FUSの細胞外分泌分子機構の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

中矢正
FUSR495X変異体による結合RNAを介したALS発症分子機構の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

中矢正
Identification of ALS linked FUS mutant induced pathological mechanism by genome-wide gene expression analyses

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

NAKAYA Tadashi
FE65による細胞内情報伝達機構の解明

科学研究費助成事業若手研究(B), 日本学術振興会, 2008 - 2009

中矢正
APP細胞内領域断片のリン酸化による細胞内情報伝達経路の制御機構解明

科学研究費助成事業若手研究(B), 日本学術振興会, 2005 - 2006

中矢正
Analysis of intracellular of APP metabolism and exploration of novel targets of drug suppressing Aβ generation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2004 - 2006

SUZUKI Toshiharu, NAKAYA Tadashi

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Papers

Misc.

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