曲薇 (WEI QU) - マイポータル

基本情報

所属: 東京大学新領域創成科学研究科特任准教授

学位: 博士(2009年3月東京大学)

研究者番号: 00631566
J-GLOBAL ID: 202001003410733639
researchmap会員ID: R000009322

研究キーワード

OMICs、GWAS、がんや神経難病の原因遺伝子解析、エピゲノム・ゲノム科学、単一細胞ゲノミクス、NGS関連アルゴリズムの開発

研究分野

ライフサイエンス / ゲノム生物学 / バイオインフォマティクス

論文

Early prediction of functional prognosis in neurofibromatosis type 2 patients based on genotype-phenotype correlation with targeted deep sequencing.

Yu Teranishi, Satoru Miyawaki, Hirofumi Nakatomi, Kenta Ohara, Hiroki Hongo, Shogo Dofuku, Atsushi Okano, Shunsaku Takayanagi, Takahiro Ota, Jun Yoshimura …

Scientific reports 12(1) 9543-9543 2022年6月9日
Targeted deep sequencing of DNA from multiple tissue types improves the diagnostic rate and reveals a highly diverse phenotype of mosaic neurofibromatosis type 2.

Yu Teranishi, Satoru Miyawaki, Hiroki Hongo, Shogo Dofuku, Atsushi Okano, Shunsaku Takayanagi, Takahiro Ota, Jun Yoshimura, Wei Qu, Jun Mitsui …

Journal of medical genetics 58(10) 701-711 2020年10月16日
Comprehensive investigation of RNF213 nonsynonymous variants associated with intracranial artery stenosis.

Hiroki Hongo, Satoru Miyawaki, Hideaki Imai, Masahiro Shimizu, Shinichi Yagi, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Koichiro Doi, Wei Qu …

Scientific reports 10(1) 11942-11942 2020年7月20日
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.

Hiroyuki Ishiura, Shota Shibata, Jun Yoshimura, Yuta Suzuki, Wei Qu, Koichiro Doi, M Asem Almansour, Junko Kanda Kikuchi, Makiko Taira, Jun Mitsui …

Nature genetics 51(8) 1222-1232 2019年8月
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

Hiroyuki Ishiura, Koichiro Doi, Jun Mitsui, Jun Yoshimura, Miho Kawabe Matsukawa, Asao Fujiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Yutaka Suzuki …

Nature genetics 50(4) 581-590 2018年4月
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.

Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda …

PLoS genetics 13(6) e1006853 2017年6月
AgIn: measuring the landscape of CpG methylation of individual repetitive elements.

Yuta Suzuki, Jonas Korlach, Stephen W Turner, Tatsuya Tsukahara, Junko Taniguchi, Wei Qu, Kazuki Ichikawa, Jun Yoshimura, Hideaki Yurino, Yuji Takahashi …

Bioinformatics (Oxford, England) 32(19) 2911-9 2016年10月1日
Comparative Analysis of Genome and Epigenome in Closely Related Medaka Species Identifies Conserved Sequence Preferences for DNA Hypomethylated Domains.

Ayako Uno, Ryohei Nakamura, Tatsuya Tsukahara, Wei Qu, Sumio Sugano, Yutaka Suzuki, Shinichi Morishita, Hiroyuki Takeda

Zoological science 33(4) 358-65 2016年8月
Assessing Cell-to-Cell DNA Methylation Variability on Individual Long Reads.

Wei Qu, Tatsuya Tsukahara, Ryohei Nakamura, Hideaki Yurino, Shin-ichi Hashimoto, Shoji Tsuji, Hiroyuki Takeda, Shinichi Morishita

Scientific reports 6 21317-21317 2016年2月18日
Associations between nucleosome phasing, sequence asymmetry, and tissue-specific expression in a set of inbred Medaka species.

Yoichiro Nakatani, Cecilia C Mello, Shin-Ichi Hashimoto, Atsuko Shimada, Ryohei Nakamura, Tatsuya Tsukahara, Wei Qu, Jun Yoshimura, Yutaka Suzuki, Sumio Sugano …

BMC genomics 16 978-978 2015年11月19日
Large hypomethylated domains serve as strong repressive machinery for key developmental genes in vertebrates.

Ryohei Nakamura, Tatsuya Tsukahara, Wei Qu, Kazuki Ichikawa, Takayoshi Otsuka, Katsumi Ogoshi, Taro L Saito, Kouji Matsushima, Sumio Sugano, Shinichi Hashimoto …

Development (Cambridge, England) 141(13) 2568-80 2014年7月
Modeling Chronic Myelomonocytic Leukemia Through Patient-Derived Induced Pluripotent Stem Cells

Keisuke Kataoka, Kazuki Taoka, Masashi Miyauchi, Masataka Hosoi, Keiki Kumano, Shunya Arai, Kazuhiro Toyama, Genta Nagae, Wei Qu, Shinichi Morishita …

BLOOD 122(21) 2013年11月査読有り
Coordinated changes in DNA methylation in antigen-specific memory CD4 T cells.

Shin-ichi Hashimoto, Katsumi Ogoshi, Atsushi Sasaki, Jun Abe, Wei Qu, Yoichiro Nakatani, Budrul Ahsan, Kenshiro Oshima, Francis H W Shand, Akio Ametani …

Journal of immunology (Baltimore, Md. : 1950) 190(8) 4076-91 2013年4月15日
Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns.

Wei Qu, Shin-ichi Hashimoto, Atsuko Shimada, Yoichiro Nakatani, Kazuki Ichikawa, Taro L Saito, Katsumi Ogoshi, Kouji Matsushima, Yutaka Suzuki, Sumio Sugano …

Genome research 22(8) 1419-25 2012年8月
Genome-wide profiling of DNA methylation in human cancer cells.

Katsumi Ogoshi, Shin-Ichi Hashimoto, Yoichiro Nakatani, Wei Qu, Kenshiro Oshima, Katsushi Tokunaga, Sumio Sugano, Masahira Hattori, Shinichi Morishita, Kouji Matsushima

Genomics 98(4) 280-7 2011年10月
Efficient frequency-based de novo short-read clustering for error trimming in next-generation sequencing.

Wei Qu, Shin-Ichi Hashimoto, Shinichi Morishita

Genome research 19(7) 1309-15 2009年7月
High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer.

Shin-ichi Hashimoto, Wei Qu, Budrul Ahsan, Katsumi Ogoshi, Atsushi Sasaki, Yoichiro Nakatani, Yongjun Lee, Masako Ogawa, Akio Ametani, Yutaka Suzuki …

PloS one 4(1) e4108 2009年
UTGB/medaka: genomic resource database for medaka biology.

Budrul Ahsan, Daisuke Kobayashi, Tomoyuki Yamada, Masahiro Kasahara, Shin Sasaki, Taro L Saito, Yukinobu Nagayasu, Koichiro Doi, Yoichiro Nakatani, Wei Qu …

Nucleic acids research 36(Database issue) D747-52 2008年1月
The medaka draft genome and insights into vertebrate genome evolution.

Masahiro Kasahara, Kiyoshi Naruse, Shin Sasaki, Yoichiro Nakatani, Wei Qu, Budrul Ahsan, Tomoyuki Yamada, Yukinobu Nagayasu, Koichiro Doi, Yasuhiro Kasai …

Nature 447(7145) 714-9 2007年6月7日
Medaka genome sequencing and the comparative genomics of fishes

Naruse Kiyoshi, Nakatani Yoichiro, Qu Wei, Kasahara Masahiro, Sasaki Shin, Yamada Tomoyuki, Budrul Ahsan, Doi Koichiro, Nagayasu Yukinobu, Hashimoto Shin-ichi …

ZOOLOGICAL SCIENCE 22(12) 1378-1379 2005年12月査読有り

もっとみる

MISC

超高速シーケンサーとバイオインフォマティクスエピゲネティック薬剤処理大腸癌細胞におけるゲノムワイドな遺伝子発現解析とDNAメチル化解析(Genome-wide gene expression and DNA methylation profiling in a colon cancer cell line treated with epigenetic drugs)

橋本真一, 曲薇, アーサン・バドルル, 生越克己, 中谷洋一郎, 佐々木惇, 鈴木穣, 菅野純夫, 森下真一, 松島綱治

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回 3S8-5 2008年11月
SOLiDシークエンス技術を用いたヒト癌細胞のゲノムワイドな遺伝子発現及び転写開始点の解析

橋本真一, Nutter Robert C, Ahsan Budrul, 曲薇, 森下真一, 松島綱治

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 80回・30回 3T13-6 2007年11月

共同研究・競争的資金等の研究課題

全ゲノム重複におけるエピゲノムの進化と制御の解明

日本学術振興会科学研究費助成事業若手研究(B) 2013年4月 - 2015年3月

曲薇