論文

査読有り
2014年4月

Long-term effects of traumatic stress on subsequent contextual fear conditioning in rats

PHYSIOLOGY & BEHAVIOR
  • Rie Ryoke
  • ,
  • Kazuo Yamada
  • ,
  • Yukio Ichitani

129
開始ページ
30
終了ページ
35
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.physbeh.2014.02.042
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Exposure to stressful events affects subsequent sensitivity to fear. We investigated the long-term effects of a traumatic experience on subsequent contextual fear conditioning and anxiety-like behaviors in rats (Experiment 1). In addition, we tested whether the administration of the glucocorticoid synthesis inhibitor metyrapone (MET) attenuated the sensitization of fear induced by traumatic stress (Experiment 2). Male rats were subjected to a multiple stress (MS) session, which consisted of 4 foot shocks (1 mA, 1 s) and forced swimming for 20 min, followed by exposure to a situational reminder 7 days after the MS session. MET (25 or 100 mg/kg, intraperitoneal) was administered 30 min before MS. The contextual fear conditioning was performed 14 days after MS. MS enhanced the conditioned fear response for at least 14 days after the conditioning, and pretreatment with MET did not affect the enhancement of conditioned fear. These results suggest that glucocorticoid secretion triggered by MS is not involved in regulating the long-term stress-induced sensitization of fear. (C) 2014 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.physbeh.2014.02.042
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24582672
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000336117300005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.physbeh.2014.02.042
  • ISSN : 0031-9384
  • PubMed ID : 24582672
  • Web of Science ID : WOS:000336117300005

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