論文

2021年8月

Association of computed tomography-derived myocardial mass with fractional flow reserve-verified ischemia or subsequent therapeutic strategy.

Heart and vessels
  • Hideki Kawai
  • Sadako Motoyama
  • Masayoshi Sarai
  • Yasuomi Nagahara
  • Kousuke Hattori
  • Yoshihiro Sato
  • Keiichi Miyajima
  • Meiko Hoshino
  • Takahiro Matsuyama
  • Masaya Ohta
  • Hiroshi Takahashi
  • Kenji Shiino
  • Atsushi Sugiura
  • Takashi Muramatsu
  • Hiroyuki Naruse
  • Junnichi Ishii
  • Hiroshi Toyama
  • Yukio Ozaki
  • Hideo Izawa
  • 全て表示

36
8
開始ページ
1099
終了ページ
1108
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00380-021-01789-z

The aim of the present study was to examine the association of myocardial mass verified by computed tomography (CT) and invasive fractional flow reserve (FFR)-verified myocardial ischemia, or subsequent therapeutic strategy for the targeted vessels after FFR examination. We examined 333 vessels with intermediate stenoses in 297 patients (mean age 69.0 ± 9.5, 228 men) undergoing both coronary CT angiography and invasive FFR, and reviewed the therapeutic strategy after FFR. Of 333 vessels, FFR ≤ 0.80 was documented in 130 (39.0%). Myocardial volume supplied by the target vessel (MVT) was larger in those with FFR-verified ischemia than those without (53.4 ± 19.5 vs. 42.9 ± 22.2 cm3, P < 0.001). Addition of MVT to a model including patient characteristics (age, gender), visual assessment (≥ 70% stenosis, high-risk appearance), and quantitative CT vessel parameters [minimal lumen area (MLA), plaque burden at MLA, percent aggregate plaque volume] improved C-index (from 0.745 to 0.778, P = 0.020). Furthermore, of 130 vessels with FFR ≤ 0.80, myocardial volume exposed to ischemia (MVI) was larger in the vessels with early revascularization after FFR examination than those without (37.2 ± 20.0 vs. 26.8 ± 15.0 cm3, P = 0.003), and was independently associated with early revascularization [OR = 1.03, 95% confidence interval (1.02-1.11), P < 0.001]. Using an on-site CT workstation, MVT identified coronary arteries with FFR-verified ischemia easily and non-invasively, and MVI was associated with subsequent therapeutic strategy after FFR examinations.

リンク情報
DOI
https://doi.org/10.1007/s00380-021-01789-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33533973
ID情報
  • DOI : 10.1007/s00380-021-01789-z
  • PubMed ID : 33533973

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