2012年6月
Roles of lactoferrin on skin wound healing
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
- ,
- 巻
- 90
- 号
- 3
- 開始ページ
- 497
- 終了ページ
- 503
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1139/O11-054
- 出版者・発行元
- CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
Skin wound healing is a complex biological process that requires the regulation of different cell types, including immune cells, keratinocytes, fibroblasts, and endothelial cells. It consists of 5 stages: hemostasis, inflammation, granulation tissue formation, re-epithelialization, and wound remodeling. While inflammation is essential for successful wound healing, prolonged or excess inflammation can result in nonhealing chronic wounds. Lactoferrin, an iron-binding glycoprotein secreted from glandular epithelial cells into body fluids, promotes skin wound healing by enhancing the initial inflammatory phase. Lactoferrin also exhibits anti-inflammatory activity that neutralizes overabundant immune response. Accumulating evidence suggests that lactoferrin directly promotes both the formation of granulation tissue and re-epithelialization. Lactoferrin stimulates the proliferation and migration of fibroblasts and keratinocytes and enhances the synthesis of extracellular matrix components, such as collagen and hyaluronan. In an in vitro model of wound contraction, lactoferrin promoted fibroblast-mediated collagen gel contraction. These observations indicate that lactoferrin supports multiple biological processes involved in wound healing.
- リンク情報
- ID情報
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- DOI : 10.1139/O11-054
- ISSN : 0829-8211
- PubMed ID : 22332789
- Web of Science ID : WOS:000304187500027