論文

査読有り 国際誌
2020年2月

Anti-reflux mucosal ablation (ARMA) as a new treatment for gastroesophageal reflux refractory to proton pump inhibitors: a pilot study.

Endoscopy international open
  • Haruhiro Inoue
  • ,
  • Mayo Tanabe
  • ,
  • Enrique Rodríguez de Santiago
  • ,
  • Mary Raina Angeli Abad
  • ,
  • Yuto Shimamura
  • ,
  • Yusuke Fujiyoshi
  • ,
  • Akiko Ueno
  • ,
  • Kazuya Sumi
  • ,
  • Hideomi Tomida
  • ,
  • Yugo Iwaya
  • ,
  • Haruo Ikeda
  • ,
  • Manabu Onimaru

8
2
開始ページ
E133-E138
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1055/a-1031-9436

Background  The incidence of proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) has been increasing. While surgical intervention with Laparoscopic Nissen Fundoplication remains the gold standard, less invasive anti-reflux interventions are desired. We have developed a minimally invasive anti-reflux mucosal ablation (ARMA) treatment. Herein, we report its technical details and describe its feasibility, safety, and efficacy in PPI-refractory GERD. Methods  We conducted a prospective single-center single-arm interventional trial evaluating the outcome of ARMA in 12 patients with PPI-refractory GERD. GERD-Health Related Quality of Life Questionnaire (GERD-HRQL) evaluation, Frequency Scale for the Symptoms of GERD (FSSG) assessment, and impedance-pH monitoring were performed at baseline and at 2 months post-ARMA. Results  A total of 12 patients underwent ARMA with a median follow-up duration of 9 months (range: 6 - 14 months). Median GERD-HRQL score significantly improved from 30.5 to 12 ( P  = 0.002); median FSSG score significantly improved from 25 to 10.5 ( P  = 0.002), and median DeMeester score decreased from 33.5 to 2.8 ( P  = 0.049) at 2 months follow-up. No immediate complications were observed. Conclusion  Our pilot study has shown that ARMA, a new endoscopic treatment for PPI-refractory GERD, is simple, safe, and improves GERD-related symptoms and objective acid reflux parameters.

リンク情報
DOI
https://doi.org/10.1055/a-1031-9436
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32010745
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976329
ID情報
  • DOI : 10.1055/a-1031-9436
  • PubMed ID : 32010745
  • PubMed Central 記事ID : PMC6976329

エクスポート
BibTeX RIS