論文

査読有り 国際誌
2020年5月16日

Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy: Experience of 109 cases.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • Kazuya Sumi
  • ,
  • Haruhiro Inoue
  • ,
  • Yasutoshi Kobayashi
  • ,
  • Yugo Iwaya
  • ,
  • Mary Raina Angeli Abad
  • ,
  • Yusuke Fujiyoshi
  • ,
  • Yuto Shimamura
  • ,
  • Haruo Ikeda
  • ,
  • Manabu Onimaru

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/den.13727

OBJECTIVES: Some patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) therapy. Anti-reflux mucosectomy (ARMS) is a minimally invasive endoscopic procedure for treatment of GERD. In this study, we retrospectively evaluated the outcomes of ARMS performed in patients with PPI-refractory GERD at our institution. METHODS: A total of 109 patients with PPI-refractory GERD who underwent ARMS were retrospectively reviewed. Pre- and post-ARMS questionnaire scores, acid exposure time (AET), DeMeester score, proximal extent, and PPI discontinuation rate were compared. RESULTS: There was a significant improvement in the symptom score (P < 0.01) and 40-50% of patients were able to discontinue PPI after ARMS. In patients who were followed up for 3 years, sustained improvement in subjective symptoms was observed. AET and DeMeester score significantly improved after ARMS (P < 0.01); however, there was no significant improvement in proximal extent (P = 0.0846). CONCLUSIONS: Anti-reflux mucosectomy is an effective minimally invasive therapy for patients with PPI-refractory GERD. The therapeutic efficacy is attributable to suppression of acid backflow due to contraction of the scar tissue in cardia.

リンク情報
DOI
https://doi.org/10.1111/den.13727
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32415898
ID情報
  • DOI : 10.1111/den.13727
  • PubMed ID : 32415898

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