2017年4月
Nucleic-Acid-Templated Enzyme Cascades
ChemBioChem
- ,
- ,
- ,
- 巻
- 18
- 号
- 8
- 開始ページ
- 696
- 終了ページ
- 716
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/cbic.201600703
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Cellular metabolism involves complex sequences of organized enzymatic reactions, known as metabolic pathways, that convert substrates into readily usable materials. In nature, these enzymatic complexes are organized in a well-defined manner so that the cascade reactions are more rapid and efficient than they would be if the enzymes were randomly distributed in the cytosol. Development of artificial enzyme cascades that resemble nature's organization of sequentially assembled enzymes is of current interest due to its potential applications, from diagnostics to the production of high-value chemicals. Nucleic acids and their nanostructures have been used to organize enzyme cascades and have been shown to enhance the efficiencies and rates of sequential reactions. Here we summarize the recent progress in the development of artificial enzyme cascades and sequential reactions by arranging enzymes on various DNA/RNA templates and discuss the future directions of this research endeavour.
- リンク情報
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- DOI
- https://doi.org/10.1002/cbic.201600703
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28150909
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399686300003&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016414810&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85016414810&origin=inward
- ID情報
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- DOI : 10.1002/cbic.201600703
- ISSN : 1439-4227
- eISSN : 1439-7633
- PubMed ID : 28150909
- SCOPUS ID : 85016414810
- Web of Science ID : WOS:000399686300003