論文

2018年

Neural Basis of Self-Reflection on Self-Face Image in Patients with Social Anxiety Disorder

不安症研究
  • KAWAGUCHI Akiko
  • ,
  • MORITA Tomoyo
  • ,
  • OKAMOTO Yasumasa
  • ,
  • NAKAAKI Shutaro
  • ,
  • KAWAGUCHI Takatsune
  • ,
  • KAN Hirohito
  • ,
  • YAMADA Takahiro
  • ,
  • AKECHI Tatsuo
  • ,
  • SADATO Norihiro

10
1
開始ページ
29-44
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.14389/jsad.10.1_29

<p>Background: Patients with social anxiety disorder (SAD) have heightened self-reflection. In the self-focused cognition, they ruminate negative self-image or evaluation both by themselves and others. It leads to self-conscious emotions, such as embarrassment. Previous functional magnetic resonance imaging (fMRI) studies with healthy subjects revealed that anterior rostral medial prefrontal cortex (arMPFC) plays a key role in self-reflection. However, neural basis of self-reflection in patients with SAD has not been studied in detail. This study aimed to investigate the neural basis of self-reflection in patients with SAD using self-face images. We hypothesized that patients with SAD would show excessive embarrassment and it would cause aberrant neural hyperactivity in arMPFC as compared to controls (CTL).</p><p>Methods: Thirteen outpatients with SAD and 17 CTLs enrolled in this study. fMRI was acquired while participants reported the degree of their embarrassment by the visually presented their self-face image and images of others' with and without an observer.</p><p>Results: The SAD group reported significantly greater embarrassment for self-face images than the CTL regardless of observation. The SAD group showed enhanced self-related activation in the left arMPFC as compared with the CTL. Furthermore, positive correlation between the self-related activity and Liebowitz Social Anxiety Scale was observed only in the arMPFC.</p><p>Conclusion: We suggest that the arMPFC takes charge of their elevated-level of self-reflection in patients with SAD, and the level of the neural activity was correlated to the severity of the symptom.</p>

リンク情報
DOI
https://doi.org/10.14389/jsad.10.1_29
URL
https://ci.nii.ac.jp/naid/130007554176

エクスポート
BibTeX RIS