論文

国際誌
2018年10月

Background field removal technique based on non-regularized variable kernels sophisticated harmonic artifact reduction for phase data for quantitative susceptibility mapping.

Magnetic resonance imaging
  • Hirohito Kan
  • ,
  • Nobuyuki Arai
  • ,
  • Masahiro Takizawa
  • ,
  • Kazuyoshi Omori
  • ,
  • Harumasa Kasai
  • ,
  • Hiroshi Kunitomo
  • ,
  • Yasujiro Hirose
  • ,
  • Yuta Shibamoto

52
開始ページ
94
終了ページ
101
記述言語
英語
掲載種別
DOI
10.1016/j.mri.2018.06.006

PURPOSE: We developed a non-regularized, variable kernel, sophisticated harmonic artifact reduction for phase data (NR-VSHARP) method to accurately estimate local tissue fields without regularization for quantitative susceptibility mapping (QSM). We then used a digital brain phantom to evaluate the accuracy of the NR-VSHARP method, and compared it with the VSHARP and iterative spherical mean value (iSMV) methods through in vivo human brain experiments. MATERIALS AND METHODS: Our proposed NR-VSHARP method, which uses variable spherical mean value (SMV) kernels, minimizes L2 norms only within the volume of interest to reduce phase errors and save cortical information without regularization. In a numerical phantom study, relative local field and susceptibility map errors were determined using NR-VSHARP, VSHARP, and iSMV. Additionally, various background field elimination methods were used to image the human brain. RESULTS: In a numerical phantom study, the use of NR-VSHARP considerably reduced the relative local field and susceptibility map errors throughout a digital whole brain phantom, compared with VSHARP and iSMV. In the in vivo experiment, the NR-VSHARP-estimated local field could sufficiently achieve minimal boundary losses and phase error suppression throughout the brain. Moreover, the susceptibility map generated using NR-VSHARP minimized the occurrence of streaking artifacts caused by insufficient background field removal. CONCLUSION: Our proposed NR-VSHARP method yields minimal boundary losses and highly precise phase data. Our results suggest that this technique may facilitate high-quality QSM.

リンク情報
DOI
https://doi.org/10.1016/j.mri.2018.06.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29902566

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