論文

国際誌
2017年6月

Water and lipid diffusion MRI using chemical shift displacement-based separation of lipid tissue (SPLIT).

Magnetic resonance imaging
  • Naoki Ohno
  • ,
  • Hirohito Kan
  • ,
  • Tosiaki Miyati
  • ,
  • Toshitaka Aoki
  • ,
  • Shota Ishida
  • ,
  • Toshifumi Gabata

39
開始ページ
144
終了ページ
148
記述言語
英語
掲載種別
DOI
10.1016/j.mri.2017.02.006

PURPOSE: To obtain water and lipid diffusion-weighted images (DWIs) simultaneously, we devised a novel method utilizing chemical shift displacement-based separation of lipid tissue (SPLIT) imaging. MATERIALS AND METHODS: Single-shot diffusion echo-planar imaging without fat suppression was used and the imaging parameters were optimized to separate water and lipid DWIs by chemical shift displacement of the lipid signals along the phase-encoding direction. Using the optimized conditions, transverse DWIs at the maximum diameter of the right calf were scanned with multiple b-values in five healthy subjects. Then, apparent diffusion coefficients (ADCs) were calculated in the tibialis anterior muscle (TA), tibialis bone marrow (TB), and subcutaneous fat (SF), as well as restricted and perfusion-related diffusion coefficients (D and D*, respectively) and the fraction of the perfusion-related diffusion component (F) for TA. RESULTS: Water and lipid DWIs were separated adequately. The mean ADCs of the TA, TB, and SF were 1.56±0.03mm2/s, 0.01±0.01mm2/s, and 0.06±0.02mm2/s, respectively. The mean D*, D, and F of the TA were 13.7±4.3mm2/s, 1.48±0.05mm2/s, and 4.3±1.6%, respectively. CONCLUSION: SPLIT imaging makes it possible to simply and simultaneously obtain water and lipid DWIs without special pulse sequence and increases the amount of diffusion information of water and lipid tissue.

リンク情報
DOI
https://doi.org/10.1016/j.mri.2017.02.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28216452

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