論文

国際誌
2007年

Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children.

Asia Pacific journal of clinical nutrition
  • Takeshi Matsuyama
  • ,
  • Kentaro Shoji
  • ,
  • Hideto Takase
  • ,
  • Isamu Kamimaki
  • ,
  • Yuriko Tanaka
  • ,
  • Atsuko Otsuka
  • ,
  • Hiroyuki Watanabe
  • ,
  • Tadashi Hase
  • ,
  • Ichiro Tokimitsu

16
1
開始ページ
40
終了ページ
8
記述言語
英語
掲載種別
研究論文(学術雑誌)

BACKGROUND: The incidence of hyperlipidemia in children is increasing in Japan, but drug therapy for such children is limited. The ingestion of 4% phytosterols-containing diacylglycerol (PS/DAG) decreases serum total cholesterol and low density lipoprotein cholesterol (LDL-C) concentrations in adults. In the present study, we examined the effect of PS/DAG as part of a diet therapy in pediatric patients with hyperlipidemia. METHODS: Pediatric patients with hyperlipidemia with > or =5.18mmol (200 mg/dL) serum total cholesterol and/or >or =1.70mmol (150 mg/dL) triglycerides (N=22) ingested bread containing PS/DAG (total daily intake, 10g) for 6 months. Blood chemistry was examined prior to and 2, 4, 6 months after the initiation of ingestion, and 4 months after the ingestion period. RESULTS: No significant differences in energy intake or cholesterol intake during the study period were found. After 4 months of ingestion of PS/DAG, LDL-C, lipoprotein(a) [ Lp(a)], free fatty acids and total ketone bodies decreased significantly. In seven patients with familial hypercholesterolemia, total cholesterol and remnant-like lipoprotein particles (RLP)-cholesterol also significantly decreased in addition to LDL-C and Lp(a). CONCLUSIONS: PS/DAG improves serum lipid metabolism in pediatric patients with hyperlipidemia for whom drug therapy is limited, suggesting that PS/DAG may reduce the risk of developing various diseases induced by hyperlipidemia.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17215179
ID情報
  • ISSN : 0964-7058
  • PubMed ID : 17215179

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