論文

国際誌
2007年12月

Suppressive effects of diacylglycerol oil on postprandial hyperlipidemia in insulin resistance and glucose intolerance.

Atherosclerosis
  • Masumi Ai
  • ,
  • Akira Tanaka
  • ,
  • Kentaro Shoji
  • ,
  • Kyoko Ogita
  • ,
  • Tadashi Hase
  • ,
  • Ichiro Tokimitsu
  • ,
  • Kentaro Shimokado

195
2
開始ページ
398
終了ページ
403
記述言語
英語
掲載種別
研究論文(学術雑誌)

The diacylglycerol (DAG), a commonly used as a cooking oil in Japan, results in a lower elevation of serum triglyceride (TG) after ingestion compared to triacylglycerol (TAG). Postprandial hyperlipidemia (PPHL) and an increase in remnant lipoproteins (RLP) levels are risk factors for CAD, and a close relationship between PPHL and type 2 diabetes and/or insulin resistance has been reported. To evaluate the effect of DAG on PPHL in insulin resistance and glucose intolerance, 11 subjects with a normal glucose tolerance (NGT) and 14 subjects with IGT received oral fat tolerance test (OFTT) twice. They ingested emulsified test oils prepared with either DAG or TAG. In the IGT subjects, after the DAG and TAG load, the serum concentrations of TG, RLP-TG, and RLP-cholesterol increased throughout the 4-h study. The responses of these variables above baseline after the DAG load were significantly smaller than those after the TAG load (p<0.05). In contrast, in the NGT subjects, changes in these parameters were much smaller than those observed for IGT subjects. The difference in the integrated responses for serum RLP-cholesterol concentration during OFTT between DAG and TAG in all subjects can be easily explained by the integrated response of insulin rather than glucose during oral glucose tolerance test (r=0.7, p<0.01). DAG was more effective in insulin resistant and hyperinsulinemic participants regardless of glucose intolerance, and may be beneficial in reducing the extent of CAD risk in such individuals.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17125771
ID情報
  • eISSN : 1879-1484
  • PubMed ID : 17125771

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