2004年12月
Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo
DENTAL MATERIALS JOURNAL
- 巻
- 23
- 号
- 4
- 開始ページ
- 650
- 終了ページ
- 655
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- JAPANESE SOC DENTAL MATERIALS DEVICES
Our previous study reported that an osteopontin-derived peptide SVVYGLR activates the adhesion, migration and tube formation abilities of endothelial cells in vitro. The present study investigated angiogenesis due to synthetic SVVYGLR and mutant peptides in vivo. Mutant peptides (n = 7) were synthesized by substituting alanine (A) for one of the 7 amino acids comprising SVVYGLR. In dorsal air sac assay, mouse dorsal skin 5 days after implantation of a chamber filled with SVVYGLR had approximately the same number of newly formed blood vessels to that filled with vascular endothelial growth factor (VEGF). The ability of angiogenesis due to SVVAGLR was significantly lower than that due to other 6 mutant peptides and SVVYGLR. This indicates that tyrosine (Y) plays an important role in angiogenesis due to SVVYGLR.
- リンク情報
- ID情報
-
- ISSN : 0287-4547
- PubMed ID : 15688734
- Web of Science ID : WOS:000227618600033