Eriko Isogai - My portal

Profile Information

Affiliation: Researcher, Division of Experimental Animal Research , Chiba Cancer Center (Research Institute)

Degree: Ph.D.

J-GLOBAL ID: 200901095110129989
researchmap Member ID: 0000001870

External link: http://www.hosp.pref.chiba.jp/gan/

Research Areas

Life sciences / Neuroscience - general /

Papers

Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation.

Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi

The Journal of investigative dermatology, 142(9) 2323-2333, Feb 28, 2022
Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.

Eriko Isogai, Kazuhiro Okumura, Megumi Saito, Yurika Tokunaga, Yuichi Wakabayashi

Biomedical research (Tokyo, Japan), 43(3) 91-97, 2022
The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.

Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yuichi Wakabayashi

Cancers, 13(5), Mar 1, 2021
CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.

Megumi Saito, Naoko Kagawa, Kazuhiro Okumura, Haruka Munakata, Eriko Isogai, Tatsuo Fukagawa, Yuichi Wakabayashi

Cancer science, 111(8) 2850-2860, Aug, 2020
Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis.

Kazuhiro Okumura, Megumi Saito, Yasuhiro Yoshizawa, Yuki Ito, Eriko Isogai, Kimi Araki, Yuichi Wakabayashi

Oncogene, 39(24) 4756-4769, Jun, 2020
A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.

Megumi Saito, Kazuhiro Okumura, Eriko Isogai, Kimi Araki, Chizu Tanikawa, Koichi Matsuda, Takehiko Kamijo, Ryo Kominami, Yuichi Wakabayashi

The Journal of investigative dermatology, 139(7) 1459-1469, Jul, 2019
The genetic polymorphism in p19Arf confers resistance to tumor progression

Saito Megumi, Okumura Kazuhiro, Isogai Eriko, Araki Kimi, Wakabayashi Yuichi

CANCER SCIENCE, 109 437, Dec, 2018 Peer-reviewed
CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model.

Kazuhiro Okumura, Naoko Kagawa, Megumi Saito, Yasuhiro Yoshizawa, Haruka Munakata, Eriko Isogai, Tatsuo Fukagawa, Yuichi Wakabayashi

Cancer science, 108(11) 2142-2148, Nov, 2017
The parathyroid hormone regulates skin tumour susceptibility in mice.

Kazuhiro Okumura, Megumi Saito, Yasuhiro Yoshizawa, Haruka Munakata, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Midori Yamaguchi, Hiroshi Shitara, Choji Taya …

Scientific reports, 7(1) 11208-11208, Sep 11, 2017
Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.

Eriko Isogai, Kazuhiro Okumura, Megumi Saito, Yasuhiro Yoshizawa, Kyoko Itoh, So Tando, Miki Ohira, Seiki Haraguchi, Akira Nakagawara, Shinji Fushiki …

Experimental animals, 64(4) 407-14, 2015
Congenic mapping and allele-specific alteration analysis of Stmm1 locus conferring resistance to early-stage chemically induced skin papillomas.

Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami, Yuichi Wakabayashi

PloS one, 9(5) e97201, 2014
Meis1 regulates epidermal stem cells and is required for skin tumorigenesis.

Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yoshimasa Aoto, Tsuyoshi Hachiya, Yasubumi Sakakibara, Yoshinori Katsuragi, Satoshi Hirose, Ryo Kominami, Ryo Goitsuka …

PloS one, 9(7) e102111, 2014
Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.

Yuyan Zhu, Yuanyuan Li, Seiki Haraguchi, Meng Yu, Miki Ohira, Toshinori Ozaki, Atsuko Nakagawa, Toshikazu Ushijima, Eriko Isogai, Haruhiko Koseki …

The Journal of clinical investigation, 123(7) 2935-47, Jul, 2013
Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.

Eriko Isogai, Miki Ohira, Toshinori Ozaki, Shigeyuki Oba, Yohko Nakamura, Akira Nakagawara

PloS one, 6(5) e19297, May 5, 2011
LMO3 interacts with p53 and inhibits its transcriptional activity.

Steven Larsen, Tomoki Yokochi, Eriko Isogai, Yohko Nakamura, Toshinori Ozaki, Akira Nakagawara

Biochemical and biophysical research communications, 392(3) 252-7, Feb 12, 2010
High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma.

Meng Yu, Miki Ohira, Yuanyuan Li, Hidetaka Niizuma, Myat Lin Oo, Yuyan Zhu, Toshinori Ozaki, Eriko Isogai, Yohko Nakamura, Tadayuki Koda …

International journal of oncology, 34(4) 931-8, Apr, 2009
Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma.

Setsuko Kaneko, Miki Ohira, Yohko Nakamura, Eriko Isogai, Akira Nakagawara, Michio Kaneko

Journal of cancer research and clinical oncology, 133(3) 185-92, Mar, 2007
Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma

H. Niizuma, Y. Nakamura, T. Ozaki, H. Nakanishi, M. Ohira, E. Isogai, H. Kageyama, M. Imaizumi, A. Nakagawara

ONCOGENE, 25(36) 5046-5055, Aug, 2006 Peer-reviewed
Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas.

Miki Ohira, Shigeyuki Oba, Yohko Nakamura, Eriko Isogai, Setsuko Kaneko, Atsuko Nakagawa, Takahiro Hirata, Hiroyuki Kubo, Takeshi Goto, Saichi Yamada …

Cancer cell, 7(4) 337-50, Apr, 2005
Identification of novel human neuronal leucine-rich repeat (hNLRR) family genes and inverse association of expression of Nbla10449/hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas.

Shiho Hamano, Miki Ohira, Eriko Isogai, Kounosuke Nakada, Akira Nakagawara

International journal of oncology, 24(6) 1457-66, Jun, 2004

Misc.

マウス系統間のPak1-3’UTRのSNPsは発現減少と腫瘍抑制に関連する

奥村和弘, 齋藤慈, 磯貝恵理子, 荒木喜美, 若林雄一

日本実験動物学会総会講演要旨集(Web), 66th, 2019
がん抑制遺伝子p19^Arfに存在する非同義置換多型の機能解析

齋藤慈, 齋藤慈, 奥村和弘, 磯貝恵理子, 若林雄一

日本実験動物学会総会講演要旨集, 65th, 2018
副甲状腺ホルモンは表皮細胞内カルシウムを制御し皮膚腫瘍形成を抑制する

奥村和弘, 齊藤慈, 吉澤康博, 宗形春花, 磯貝恵理子, 木南凌, 若林雄一

日本癌学会総会記事, 76回 E-1030, Sep, 2017
発がん抵抗性遺伝子座Stmm3の原因遺伝子の同定と機能解析

齋藤慈, 奥村和弘, 吉澤康博, 宗形春花, 磯貝恵理子, 若林雄一

日本癌学会総会記事, 76回 P-1008, Sep, 2017
Stmm1a(Skin tumour modifier of MSM/Ms)に位置するPak1はその発現低下により細胞増殖を抑制する

吉澤康博, 奥村和弘, 齋藤慈, 宗形春花, 青戸良賢, 磯貝恵理子, 榊原康文, 若林雄一

日本癌学会総会記事, 76回 P-1009, Sep, 2017
ChIP sequencingにより示唆されたMeis1の皮膚腫瘍におけるグルコース代謝の制御

吉澤康博, 奥村和弘, 齋藤慈, 宗形春花, 青戸良賢, 磯貝恵理子, 榊原康文, 若林雄一

日本癌学会総会記事, 75回 P-2019, Oct, 2016
マウス4番染色体上に存在する腫瘍悪性化を制御する原因遺伝子の探索

齋藤慈, 奥村和弘, 吉澤康博, 宗形春花, 磯貝恵理子, 若林雄一

日本癌学会総会記事, 75回 P-2026, Oct, 2016
コンジェニックマッピングおよび遺伝子発現解析による皮膚がん抵抗性遺伝子座Stmm1aの原因遺伝子探索

奥村和弘, 齊藤慈, 吉澤康博, 磯貝恵理子, 三浦郁生, 若菜茂晴, 木南凌, 若林雄一

日本実験動物学会総会講演要旨集, 63rd, 2016
多段階皮膚発がん実験を用いたマウスがん抵抗性遺伝子座Stmm1aの遺伝学的解析

奥村和弘, 吉澤康博, 齋藤慈, 宗形春花, 磯貝恵理子, 三浦郁生, 若菜茂晴, 木南凌, 若林雄一, 若林雄一

日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
ChIP sequencingをもちいた皮膚腫瘍におけるMeis1の機能解析

吉澤康博, 吉澤康博, 奥村和弘, 齋藤慈, 齋藤慈, 青戸良賢, 磯貝恵理子, 榊原康文, 若林雄一

日本実験動物学会総会講演要旨集, 63rd, 2016
皮膚悪性腫瘍においてMeis1が制御する下流因子の探索

吉澤康博, 吉澤康博, 奥村和弘, 齋藤慈, 齋藤慈, 宗形春花, 宗形春花, 青戸良賢, 磯貝恵理子, 榊原康文 …

日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
マウス扁平上皮がん由来細胞を用いたc-Met阻害におけるMeis1の機能解析

齋藤慈, 奥村和弘, 吉澤康博, 宗形春花, 磯貝恵理子, 若林雄一

日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
発がん抵抗性遺伝子座Stmm3の探索と機能解析

齋藤慈, 奥村和弘, 磯貝恵理子, 三浦郁生, 若菜茂晴, 木南凌, 若林雄一

日本実験動物学会総会講演要旨集, 62nd, 2015
マウス皮膚発がんモデルを用いたがん抵抗性/感受性遺伝子の同定

奥村和弘, 齋藤慈, 吉澤康博, 磯貝恵理子, 若林雄一

日本遺伝学会大会プログラム・予稿集, 87th, 2015
副甲状腺ホルモンのマウス皮膚腫瘍形成における機能

奥村和弘, 齋藤慈, 磯貝恵理子, 三浦郁生, 若菜茂晴, 島貫碧, 設楽浩志, 多屋長治, 木南凌, 若林雄一

日本実験動物学会総会講演要旨集, 62nd, 2015
マウス4番染色体上に存在する腫瘍悪性化を制御するStmm3遺伝子座の探索(Identification of Stmm3 locus controlling tumor progression on mouse chromosome 4)

齋藤慈, 奥村和弘, 磯貝恵理子, 若菜茂晴, 木南凌, 若林雄一

日本癌学会総会記事, 73回 P-2053, Sep, 2014
マウス4番染色体上に存在するStmm3遺伝子座の探索と機能解析

齋藤慈, 奥村和弘, 磯貝恵理子, 三浦郁生, 若菜茂晴, 木南凌, 若林雄一

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
多段階皮膚発がんによる新規良性腫瘍抵抗性遺伝子座Stmm1の遺伝学的解析

奥村和弘, 齋藤慈, 磯貝恵理子, 若林雄一

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
Meis1は表皮幹細胞の維持と化学発がん誘導皮膚腫瘍の発症において必須である

若林雄一, 奥村和弘, 齋藤慈, 青戸良賢, 榊原康文, 木南凌, 後飯塚僚, 中村卓郎, 磯貝恵理子

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
High expression of ncRAN, a long non-coding RNA mapped to 17q25, is associated with aggressiveness and poor prognosis of neuroblastoma

Miki Ohira-Ichikawa, Yu Meng, Yuanyuan Li, Hidetaka Niizuma, Yuyan Zhu, Toshinori Ozaki, Eriko Isogai, Yohko Nakamura, Tadayuki Koda, Shigeyuki Oba …

CANCER RESEARCH, 69, May, 2009

Professional Memberships

Research Projects

神経幹細胞による大脳発生と脳腫瘍発症機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

磯貝恵理子, 若林雄一, 奥村和弘
多段階発がん過程におけるMeis1経路の網羅的機能解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2022

若林雄一, 磯貝恵理子
Analysis of neuronal tumorigenesis using mouse models

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Isogai Eriko
Identification of cancer-related gene polymorphisms by genetic integration of mouse and human

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Okumura Kazuhiro, Wakabayashi Yuichi, Taya Chouji, Sakakibara Yasubumi, Matsuda Koichi
Elucidation of the mechanisms of carcinogenesis regulated by oxidative stress response

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

WAKABAYASHI Yuichi, SAKAKIBARA Yasubumi
Analysis of mechanisms to develop hydrocephalus using mice model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Isogai Eriko, OHIRA Miki, HASEGAWA Yuzo
Regulation of Mash1 transcription and cell growth by genes identified in gene expression analysis of cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

ISOGAI Eriko
小児癌由来遺伝子材料を基盤とした疾病関連遺伝子の探索と病態解明への応用

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2008 - 2009

大平美紀, 磯貝恵理子, 中川原章, 大羽成征
小児癌由来遺伝子材料を基盤とした疾病関連遺伝子の探索と病態解明への応用

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2006 - 2007

大平美紀, 磁貝恵理子, 中川原章, 大羽成征
小児癌由来cDNAチップを用いた正常個体発生の遺伝子発現ネットワークの網羅的解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2004 - 2004

大平美紀, 磯貝恵理子, 中川原章
神経特異的DNAチップの作製と神経発生の遺伝子発現ネットワークの網羅的解析

科学研究費助成事業特定領域研究(C), 特定領域研究(C), 日本学術振興会, 2001 - 2002

大平美紀, 磯貝恵理子
Analysis of the biological function of the BMP binding factor, DAN, during osteoblast differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

NAKAMURA Yohko, ISOGAI Eriko
神経特異的DNAチップの作製と神経発生遺伝子ネットワークの網羅的解析

科学研究費助成事業特定領域研究(C), 特定領域研究(C), 日本学術振興会, 2000 - 2000

市川美紀, 磯貝恵理子
Molecular mechanism of spontaneous regression of neuroblastoma and its application to the therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1998 - 1999

NAKAGAWA Akira, NAKAMURA Yuko, KAGEYAMA Hajume, OZAKI Toshinori, ISOGAI Eriko