2017年4月
Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column
FORENSIC SCIENCE INTERNATIONAL
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- 巻
- 273
- 号
- 開始ページ
- 39
- 終了ページ
- 44
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.forsciint.2017.01.025
- 出版者・発行元
- ELSEVIER IRELAND LTD
The enantiomers of methamphetamine were differentiated by supercritical fluid chromatography (SFC) with an enantioselective cellulose-based packed column. The optimization of the chromatographic conditions was achieved by changing column temperature, co-solvent proportion, additive concentration, flow rate and back pressure. In particular, the additive concentration crucially changed the resolution between the enantiomers. After determining the optimized conditions, the enantiomers of methamphetamine were successfully separated. The analytical precision, accuracy and limit of detection were checked by using the authentic standard and seized real samples. We believe that chiral SFC is a promising method for enantioseparation of forensic samples. (C) 2017 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.forsciint.2017.01.025
- ISSN : 0379-0738
- eISSN : 1872-6283
- PubMed ID : 28213186
- Web of Science ID : WOS:000401097300010