Tosifusa Toda - My portal

Profile Information

Affiliation: Senior Research Scientist, Yokohama City University

Degree: Ph.D.(Osaka University)

J-GLOBAL ID: 200901028456591205
researchmap Member ID: 0000009237

External link: http://www.proteome.jp/TMIG-PCC/

Research Interests

Research Areas

Research History

Dec, 2011 - Present

特任教授, 先端医科学研究センター, 公立大学法人横浜市立大学
Apr, 2009 - Nov, 2011

Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Apr, 2005 - Mar, 2009

研究副部長, 老化ゲノムバイオマーカー研究チーム, 財団法人東京都高齢者研究・福祉振興財団東京都老人総合研究所
Apr, 2002 - Mar, 2005

グループリーダー, プロテオーム共同研究グループ, 財団法人東京都高齢者研究・福祉振興財団東京都老人総合研究所
Apr, 1993 - Mar, 2002

主任研究員, 遺伝子情報部門, 財団法人東京都老人総合研究所
Apr, 1988 - Mar, 1993

研究員, 分子生物学部門, 財団法人東京都老人総合研究所
Apr, 1977 - Mar, 1988

助手, 生化学部, 東京都老人総合研究所

Education

Committee Memberships

1998

広報担当常務理事, 日本電気泳動学会

Awards

Papers

Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme

Kuniko Akama, Tomoe Horikoshi, Atsushi Sugiyama, Satoko Nakahata, Aoi Akitsu, Nobuyoshi Niwa, Atsushi Intoh, Yasutaka Kakui, Michiko Sugaya, Kazuo Takei …

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804(6) 1272-1284, Jun, 2010 Peer-reviewed
Involvement of Galectin-3 with Vascular Cell Adhesion Molecule-1 in Growth Regulation of Mouse BALB/3T3 Cells

Tomomi Tadokoro, Masahiko Ikekita, Tosifusa Toda, Hiroko Ito, Takeshi Sato, Ryunosuke Nakatani, Yu Hamaguchi, Kiyoshi Furukawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(51) 35556-35563, Dec, 2009 Peer-reviewed
Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress

Megumi Nakamura, Hiraku Morisawa, Shinobu Imajoh-Ohmi, Chizuko Takamura, Hiroyuki Fukuda, Tosifusa Toda

EXPERIMENTAL GERONTOLOGY, 44(6-7) 375-382, Jun, 2009 Peer-reviewed
Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma

Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Hashimoto R, Mori M

J. Electrophoresis, 53(1) 1-6, 2009 Peer-reviewed
Proteomic analysis of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines before and after immortalization

Toda, T, Sugimoto, M, Omori, A, Matsuzaki, T, Furuichi, Y, Kimura, N

Electrophoresis, 21(9) 1814-1822, 2009 Peer-reviewed

Misc.

Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress

Megumi Nakamura, Hiraku Morisawa, Shinobu Imajoh-Ohmi, Chizuko Takamura, Hiroyuki Fukuda, Tosifusa Toda

EXPERIMENTAL GERONTOLOGY, 44(6-7) 375-382, Jun, 2009
Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma.

Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Hashimoto R, Mori M

J. Electrophoresis,, 53(1) 1-6, 2009
Analysis of glycopeptides using lectin affinity chromatography with MALDI-TOF mass spectrometry

Kazutosi Kubota, Yuji Sato, Yusuke Suzuki, Naoko Goto-Inoue, Tosifusa Toda, Minoru Suzuki, Shin-ichi Hisanaga, Akemi Suzuki, Tamao Endo

ANALYTICAL CHEMISTRY, 80(10) 3693-3698, May, 2008
Proteomic identification of differentially expressed genes in mouse neural stem cells and neurons differentiated from embryonic stem cells in vitro

Kuniko Akama, Ryosuke Tatsuno, Masahiro Otsu, Tomoe Horikoshi, Takashi Nakayama, Megumi Nakamura, Tosifusa Toda, Nobuo Inoue

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1784(5) 773-782, May, 2008
Molecular characterization of axonemal proteins and signaling molecules responsible for chemoattractant-induced sperm activation in Ciona intestinalis

Akiko Hozumi, Potturi Padma, Tosifusa Toda, Hiroyuki Ide, Kazuo Inaba

CELL MOTILITY AND THE CYTOSKELETON, 65(3) 249-267, Mar, 2008
Proteomic study on X-irradiation-responsive proteins and ageing: Search for responsible proteins for radiation adaptive response

Yuri Miura, Mayumi Kano, Masaki Yamada, Tsutomu Nishine, Shiro Urano, Shozo Suzuki, Tamao Endo, Tosifusa Toda

JOURNAL OF BIOCHEMISTRY, 142(2) 145-155, Aug, 2007
Abnormal N-glycosylation of the immunoglobulin G kappa chain in a multiple myeloma patient with crystalglobulinemia: Case report

Ryo Hashimoto, Tosifusa Toda, Hisashi Tsutsumi, Masatsugu Ohta, Mayumi Mori

INTERNATIONAL JOURNAL OF HEMATOLOGY, 85(3) 203-206, Apr, 2007
A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells

Hajime Kurosaki, Yasuhiro Kazuki, Masaharu Hiratsuka, Toshiaki Inoue, Yasuhisa Matsui, Chi Chiu Wang, Mito Kanatsu-Shinohara, Takashi Shinohara, Tosifusa Toda, Mitsuo Oshimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 353(2) 259-267, Feb, 2007
Proteomic identification of oxidative-stress-reporting biomarkers differentially secreted from human neuroblastoma SH-SY5Y cells

TODA Tosifusa, NAKAMURA Megumi, MORISAWA Hiraku, HIROTA Mikako

Journal of Electrophoresis, 51(3/4) 21-26, 2007
The protein expression profile of cynomolgus monkey embryonic stem cells in two-dimensional gel electrophoresis : a successful identification of multiple proteins using human databases

NAKAHARA Masako, SAEKI Kumiko, YOGIASHI Yoshiko, KIMURA Akiko, HORIUCHI Akiko, NAKAMURA Naoko, YONEDA Asako, SAEKI Koichi, MATSUYAMA Satoko, NAKAMURA Megumi …

Journal of Electrophoresis, 51(1) 1-8, 2007
Identification and characterization of an increased glycoprotein in aging: Age-associated translocation of cathepsin D

Yuji Sato, Yusuke Suzuki, Emi Ito, Sayaka Shimazaki, Masami Ishida, Takaki Yamamoto, Haruhiko Yamamoto, Tosifusa Toda, Minoru Suzuki, Akemi Suzuki …

MECHANISMS OF AGEING AND DEVELOPMENT, 127(10) 771-778, Oct, 2006
Molecular characterization of Ciona sperm outer arm dynein reveals multiple components related to outer arm docking complex protein 2

Akiko Hozumi, Yuhkoh Satouh, Yumiko Makino, Toshifusa Toda, Hiroyuki Ide, Kazuo Ogawa, Stephen M. King, Kazuo Inaba

CELL MOTILITY AND THE CYTOSKELETON, 63(10) 591-603, Oct, 2006
Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow

Hiraku Morisawa, Mikako Hirota, Tosifusa Toda

BMC BIOINFORMATICS, 7 430-440, Oct, 2006
Analysis of protein-protein interactions with a multi-capillary electrophoresis instrument

K Shimura, T Waki, M Okada, T Toda, Kimoto, I, K Kasai

ELECTROPHORESIS, 27(10) 1886-1894, May, 2006
Increased expression and phosphorylation of liver glutamine synthetase in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus

Y Kuramitsu, T Harada, M Takashima, Y Yokoyama, Hidaka, I, N Iizuka, T Toda, M Fujimoto, XL Zhang, Sakaida, I …

ELECTROPHORESIS, 27(8) 1651-1658, Apr, 2006
Evidence for a role of collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

CGT Tahimic, N Tomimatsu, R Nishigaki, A Fukuhara, T Toda, K Kaibuchi, G Shiota, M Oshimura, A Kurimasa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340(4) 1244-1250, Feb, 2006
Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin

K Saeki, E Yasugi, E Okuma, SN Breit, M Nakamura, T Toda, Y Kaburagi, A Yuo

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 289(3) E419-E428, Sep, 2005
Proteomic identification of differentially-expressed genes in human gastric carcinomas

R Nishigaki, M Osaki, M Hiratsuka, T Toda, K Murakami, KT Jeang, H Ito, T Inoue, M Oshimura

PROTEOMICS, 5(12) 3205-3213, Aug, 2005
Comparison of hippocampal synaptosome proteins in young-adult and aged rats

Y Sato, H Yamanaka, T Toda, Y Shinohara, T Endo

NEUROSCIENCE LETTERS, 382(1-2) 22-26, Jul, 2005
Age-dependent variations of cell response to oxidative stress: Proteomic approach to protein expression and phosphorylation

Y Miura, M Kano, K Abe, S Urano, S Suzuki, T Toda

ELECTROPHORESIS, 26(14) 2786-2796, Jul, 2005

Professional Memberships

Research Projects

細胞老化のプロテオーム解析

国際共同研究, 1996
老化バイオマーカー探索
Proteomic Analysis of Cellular Aging

International Joint Research Projects