TAKAHASHI Saori

J-GLOBAL         Last updated: Sep 24, 2019 at 11:47
 
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Name
TAKAHASHI Saori
Affiliation
Akita Research Institute of Food and Brewing
Job title
Director
Degree
Doctor of Agriculture (Ph.D.)

Research Areas

 
 

Academic & Professional Experience

 
1980
 - 
1989
Researcher, National Cardiovascular
 
 
   
 
Center Research Institute
 
1989
 - 
1992
Senior Researcher, National Cardiovascular
 
 
   
 
Center Research Institute
 
1992
 - 
1997
Associate Professor, Kyoto Institute of
 
 
   
 
Technology
 
1997
   
 
- Senior Researcher, Akita Research Institute of
 
 
   
 
Food and Brewing
 
2002
 - 
2009
Chief Researcher,Akita Research Institute of Food and Brewing
 
2009
   
 
- Director Insitute of Food Processing, Akita Res. Inst. Food & Brew.
 

Committee Memberships

 
1980
   
 
Japan Society for Bioscience, Biotechnology and Agrochemistry  
 
1998
   
 
Japanese Society for chitin and chitosan  
 
1980
   
 
The Japanese Biochemical Society  
 

Published Papers

 
Cloning and characterization of the novel D-aspartyl endopeptidase, paenidase, from Paenibacillus sp. B38.
Satoru Nirasawa, Kazuhiko Nakahara, and Saori Takahashi
J. Biochem.   164(2) 103-112   Aug 2018   [Refereed]
Inhibition of renin-angiotensin system related enzymes (renin, angiotensin converting enzyme, chymase and angiotensin converting enzyme 2) by water shield extracts
Saori Takahashi et al.
J. Biol. Macromol.   17(1) 3-13   Jun 2017   [Refereed]
Masahiro Ogasawara, Mieko Otani, Masaoki Takano, Masachika Shudou, Yohei Inaba, Satoru Nirasawa, Saori Takahashi, Takeshi Kiyoi, Yuki Tanaka, Keiji Kameda, Naoki Kunugita, Kazutaka Maeyama, Keijio Sano, Masahiro Yamashita, and Kohei Yamauchi
Experimental Lung Research   42(5) 245-262   Jun 2016   [Refereed]
Ardiansyah, Hitoshi Shirakawa, Puspo E. Giriwono, Kazuki Oguchi, Kazuma Ueda, Hideki Hokazono, Kazuyuki Hiwatashi, Saori Takahashi, Shoko Sato, and Michio Komai
Biosci. Biotechnol. Biochem.   79(11) 1876-1883   Nov 2015   [Refereed]
Saori Takahashi, Taku Yoshiya, Kumiko Yoshizawa-Kumagae, and Toshihiro Sugiyama
Biomed. Res.   36(3) 219-224   Jun 2015   [Refereed]
Md Alauddin, Hitoshi Shirakawa, Kazuyuki Hiwatashi, Atsushi Shimakage, Saori Takahashi, Mamoru Shinbo, and Michio Komai
Journal Functional Foods   14 126-132   Jan 2015   [Refereed]
Takeishi Goto, Ken-Ichi Kukuchi, Kazuyuki Hori, and Saori Takahashi
Japanese Journal of Food Chemistry and Safety   22(1) 18-24   Jan 2015   [Refereed]
Hiroki Maeda, Takumi Takata, Norihiko Fujii, Hiroaki Sakaue, Satoru Nirasawa, Saori Takahashi, Hiroshi Sasaki, and Noriko Fujii
Analytical Chemistry   87 561-568   2015   [Refereed]
Tetsuro Hisayoshi, Mayu Shimomura, Kanta Yokokawa, Atsushi Kinishi, Kumi Kawaji, Eiichi N. Kodama, Keishi Hata, Saori Takahashi, and Kiyoshi Yasukawa
J. Natl. Med.   69 432-440   2015   [Refereed]
Tomoyo Nishihira, Asami Miyano, Takayuki Ohnuma, Takeshi Goto, Saori Takahashi, Kazue Narihiro, Kazuhiko Yakashita, and Tamo Fukamizo
Journal of Applied Glycoscience   61(4) 113-116   Oct 2014   [Refereed]

Misc

 
OHNO Toshihisa TAKAHASHI Saori
Nippon Shokuhin Kagaku Kougaku Kaishi   61(11) 552-554   Oct 2014   [Refereed]
Atsushi Shimakage, Mamoru Shinbo, Seihan Yamada, Ardiansyah, Hitoshi Shimakage, Michio Komai, Kazuyuki Howatashi, Makoto Tomatsu, and Saori Takahashi
Shokuhin and Rinsyou Eiyou   e2011 1-8   2011   [Refereed]
N-Acetyl-D-glucosamine 2-epimerase: Effects of nucleotides on the structure and enzyme activity. (Japanese)
Saori Takahashi
Chitin and Chtosan Research   14(2) 45-53   2007
Novel assay method for N-acetylglucosamine 2-epimerase (Japanese)
Saori Takahashi and Kazuyuki Hori
Chitin and Chitosan Research   14(1) 13-17   2007
Paenidase, a novel D-aspartyl endopeptidase from Paenibacillus sp. B38: Purification and substrate specificity.
J. Biochem.   138(2), 197-202    2006
Antibacterial isoflevones from Eysenharaditia] edenostylis.
Natural Medicines   58, 166    2004
Evaluation sake by an Odor sensor
J,Am.Soc.Brew.chem   59(2) 77-79   2001   [Refereed]
Effects of Nucleotides on N-Acetyl-D-Glucosamine 2-Epimerases(Renm Binding Proteims):Comparotiue Biochonical studies
J.Biochem   130(6), 815-821    2001
Characterization of human Renin binding Protein (RnBP): Human RnBP has N-Acetyl-D-Glucosamine 2-Epimerase activity
Advances in Chitin Science Vol.3 RITA Adrertising Co. LTD. Taipei   178-184    1998
Identification of Cysteine-380 as the Essential Residue for the Human N-Acetyl-D-Glucosamine
2-Epimerase (Renin Binding Protein), (1999), J.Biochem.126, 639-642   

Books etc

 
Soybean Biochemistry, Chemistry and Physiology.
Saori Takahashi, Takeshi Gotoh, and Kazuyuki Hori (Part:Joint Work, Renin Inhibitor in Soybean.)
InTech   2011   
Advances in Chitin Science, Vol. 9 pp 89-94
Saori Takahasi, Kazuyuki Hori, Kazuyuki Hiwatashi, Hironobu Ogasawara, and Toshihiro Sugiyama (Part:Joint Work, Stabilization of GlcNAc 2-epimerase (renin binding protein) by nucleotides.)
2006   
Advances in Chitin Science Vol. 8
Saori Takahashi et al.
Institute of Plant Science Protection, Poznan   2005   
Identifiation of nucleotide binding residues for N-acetyl-D-glucosamine 2-epimerase.
Advances in Chitin Science   2005   
Advance in Chitin Science Vol. 6
Saori Takahashi et al. (Part:Joint Work, Effects of nucleitodes on N-acetyl-D-glucosamine 2-epimerase (renin binding protein).)
NTNU Trondheim, Norway   2002   
Chitin Enzymology 2001
Saori Takahasi et al. (Part:Joint Work, Essential cysteine residues of human N-acetyl-D-glucosamine 2-epimerase.)
Atec Edizioni, Italy   2001   
Chitin and Chitosan. Chitin and Chitosan in Life science.
Saori Takahashi et al. (Part:Joint Work, Human N-acetyl D-glucosamine 2-epimerase: Identification of essential resideu(s) by site-directed mutagenesis.)
Kodansha Scientific LTD. Tokyo   2001   
Human N-Acetyl-D-Glucosamine 2-Epimerase:Identification of Essential Cysteine Resiclue(s) by Site-Directed Mutagenesis
Chitin and chitosan, Kodansha Scientific LTD. Tokyo   2001   
Essential cysteine Residues of the Human N-Acetyl-D-Glucosamine
in chitim Enzymology, Atec Edizioni, Grottammare, Italy   2001   
Advances in Chitin Science Vol. 4
Saori Takahashi et al. (Part:Joint Work, Structure and function of human N-acetyl-D-glucosamine 2-epimerase (renin binding protein). Identification of active site residue.)
University of Potsdam Press   2000   
Structure and Function Relationship of Human N-Acetyl-D-Glucosamine 2-Epimerase (Renin Binding Protein). -Identification of Active Site Residue-
in Advances in Chitin Science Bol.4 (Peter, M. G., Domard, A., and Muzzarelli, R. A. A,. eds.) University of Potsdam, Germany   2000   
Aspartic Proteinases
Kohei Oda, Saori Takahashi, Masaaki Ito, and Ben M. Dunn (Part:Joint Work, Pepstatin-insensitive carboxy proeinase from prokaryotes: Catalytic residues and substrate specifcity.)
Plenum Press, New York   1998   
Advances in Chitin Science Vol. 3
Saori Takahashi et al.
RITE Advertising Co. Ltd., Taipei   1998   
Characterization of human renin binding protein (RnBP) : Human RnBP has N-acetyl-D-glucosamine 2-epimerase activity
RITA Adrertising. co. Ltd , Advances in chitin Science Vol. 3   1998   
Pepstatin-insensitive carboxyl proteinase from prokayotes : Catalytic residues and substrate specificities
Plenum Press NewYork , (in Aspartic Proteinases)   1998   
Pepstatin-insensitive Carboxyl Proteinases from Prokaryotes.
Plenum Press, New York.   1998   
Aspartic Proteinases: Structure, Function and Biochemical implication.
Plenum Press, New York   1995   
Pepstatin-insensitive carboxyl proteinases.
Plenum Press, New York   1995   
Kinin and Angiotensin
1994   
Flavin and Flavoproteins 1990
Motoshige Miyano, Kiyoshi Fukui, Fusao Watanabe, Masazumi Tada, Saiori Takjahashi, and Yoshihiro Miyake (Part:Joint Work, Purificationof recombinant mutant D-amino acid oxidase.)
Walter de Gruyter. Berlin, New York   1991   
Purification of recombinant mutant D-amino acid oxidases.
Walter de Gruyter, Berlin. New York   1991   
Molecular biological studies on structure-function relationship of D-amino acid oxidase.
Walter de Gruyter, Berlin, New York   1991   
Kinin V, Part B.
Akiko Irie, Saori Takahashi et la. (Part:Joint Work, Purification and immunological properties of human urinally kallikrein and prokallikrein.)
Plenum Publishing Cprporation   1989   
Kinin V, Part A
Saori Takahasi et al. (Part:Joint Work, Human urinally prokallikrein -Structural analysis on activation mechanism.)
Plenum Publishing Cprporation   1989   
Purification and immunological properties of human urinary kallikrein and prokallikrein.
Plenum Publishing Corporation.   1989   
Human urinary prokallikrein. -Structural analysis on activation mechanism.
Plenum Publishing Corporation.   1989   
Progress in Endocrinology 1988
Detlev Ganten, Saori Takahashi et al. (Part:Joint Work, The renin-angiotyensin system in cardiovascular tissues: From molecular biology to therapy.)
Elsevier Scientific Publisher B. V.   1988   
The renin-angiotensin system in cardiovascular tissue: From molecular biology to therapy.
Elsevier Scientific Publishers. B. V.   1988   
Heterogeneity of Renin and Renin-Substrate
K. Murakami, S. Takahashi, S. Hirose, and T. Inagami (Part:Joint Work, Purification and charactrization of renin precursor in hog kidney.)
Elsevier   1981   
Purification and characterization of renin precursor in hog kidney.
Elsevier, North Holland Inc.   1981   
Effects of nucleotides on N-acetyl-D-glucosamine 2-epimerase (remn binding protein)
NTNU Trondheim, (in Advances in chitin Science Vol.6)   

Conference Activities & Talks

 
B38-CAP, a bacteria-derived ACE2-like enzyme, supresses cardiac remodeling and dysfunction in mice.
Takafumi Minato, Satoru Nirasawa, Teruki Sato, Ryo Ozawa, Hiroyuki Watanabe, Saori Takahashi, and Keiji Kuba
The 2nd JSC Council Forum on Basic Cardiovascular Research   22 Sep 2018   
Properties of carboxypeptidase deived from D-aspartyl endopepitidase producing bacteria Paenibacillus sp. B38.
Satoru Nirasawa, Taku Yoshiya, Kumiko Yoshizawa-Kumagae, Kiyohito Kihira, and Saori Takahashi
8 Dec 2017   
Processed soymilk significantly rediced blood pressure in spontaneously hypertensive rats compared to regular soymilk.
TAKAHASHI Saori
28 Mar 2015   
Processed soymilk effectively ameliorates blood pressure elevation in spontaneously hypertensive rats.
M. Alauggin, Hitoshi Shirakawa, Kazuyuki Hiwatashi, Atsushi Shimakage, Saori Takahashi, Mamoru Shinbo, and Michio Komai
31 May 2014   
Characterization of the cellobiose 2-epimerase from the D-aspartic acid specific endopeptidase-producing bacteria, Oaenibacillus sp. B38.
Satoru Nirasawa and Saori Takahashi
10th Asia Pacific Chitin and Chitosan Symposium & 27th Chitin/Chitosan Symposium   4 Oct 2013   
Effective production of human angiotensin-converting enzyme 2 by Sf-9 insect cells.
Mai Miyawaki, Kenta Tsudhiya, Saki Yokota, Saori Takahashi, Satoru Nirasawa, and Takeshi Gotoh
28 Sep 2013   
Characterization and structure-activity relationship of novel D-aspartyl endopeptidase from prokaryote.
Satoru Nirasawa and Saori Takahashi
11 Sep 2013   
Involvement of D-aspartic acid isomerization of lung proteins in the pathogenesis of chronic obstruction lung desease (COPD).
Masahito Ogasawara, Mieko Otani, Satoru Nirasawa, Saori Takahashi, Kazuhito Maeda, and Kohei Yamauchi
14 Dec 2012   
Post-transcriptional suppression against potential transposable elements by cryptic splicing and premature polyadenylation in Aspergillus oryzae.
Hironobu Ogasawara, Saori Takahashi, and Katsuya Gomi
9th Aspergillus Meeting and 11th European Conference on Fungal Genetics   29 Mar 2012   
Protein isoasprtyl methyltransferase gene knock down induced human alveolar epithelial to mesencymal cell transition through endoplasmic reticulum stress.
9 Dec 2011   

Research Grants & Projects

 
Molecular biological Studies on renin binding protein
Project Year: 1997   
Renin inhibitr from foodstuffs