笹月健彦 (Takehiko Sasazuki) - マイポータル - researchmap

基本情報

所属: 独立行政法人国立国際医療研究センター研究所長

学位: 医学博士

J-GLOBAL ID: 200901017470775910
researchmap会員ID: 0000013326

研究キーワード

5

経歴

28

2001年

国立国際医療センター研究所長
1996年

Director of Medical Institute of Bioregulation,
1992年

九州大学
1990年

Director of Medical Institute of Bioregulation,
1985年

Released from the concurrent work as Professor, Tokyo
1984年

九州大学生体防御医学研究所教授
1984年

Professor, Kyushu University and Tokyo Medical and
1983年

Professor, Kyushu University, Medical Institute of
1977年

東京医科歯科大学教授難治疾患研究所教授
1977年

Professor, Tokyo Medical and Dental University,
1976年

東京医科歯科大学難治疾患研究所助教授
1976年

Associate Professor, Tokyo Medical and Dental
1976年

Immunology) (until August 1976)
1973年

米国スタンフォード大学Research Associate
1973年

Research Associate, Stanford University, USA.
1970年

東京医科歯科大学遺伝病研究施設助手
1970年

Research Assistant, Tokyo Medical and
九州大学
Medical and Dental University
Dental University (concurrently)

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学歴

4

受賞

12

MISC

34

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Yoshinori Fukui, Osamu Hashimoto, Terukazu Sanui, Takamasa Oono, Hironori Koga, Masaaki Abe, Ayumi Inayoshi, Mayuko Noda, Masahiro Oike, Toshikazu Shirai …

Nature 412(6849) 826-831 2001年8月23日
Quantitation of HLA-A *0201 bound tumor associated antigens on a peptide pulsed B cell line

Hiroshi Wataya, Nobuhiro Kamikawaji, Yoichi Nakanishi, Koichi Takayama, Nobuyuki Hara, Takehiko Sasazuki

Human Immunology 62(2) 125-132 2001年
Rnx deficiency results in congenital central hypoventilation

Senji Shirasawa, Akiko Arata, Hiroshi Onimaru, Kevin A. Roth, Gary A. Brown, Susan Horning, Satoru Arata, Koji Okumura, Takehiko Sasazuki, Stanley J. Korsmeyer

Nature Genetics 24(3) 287-290 2000年3月
Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor

Takehiko Sasazuki, Takeo Juji, Yasuo Morishima, Naoko Kinukawa, Hidehiko Kashiwabara, Hidetoshi Inoko, Takato Yoshida, Akinori Kimura, Tatsuya Akaza, Nobuhiro Kamikawaji …

New England Journal of Medicine 339(17) 1177-1185 1998年10月22日
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

A. Kimura, H. Harada, J. E. Park, H. Nishi, M. Satoh, M. Takahashi, S. Hiroi, T. Sasaoka, N. Ohbuchi, T. Nakamura …

Nature Genetics 16(4) 379-382 1997年
Human CD4-Major Histocompatibility Complex Class II (DQw6) Transgenic Mice in an Endogenous CD4/CD8-deficient Background: Reconstitution of Phenotype and Human-restricted Function

Rae S. M. Yeung, Josef M. Penninger, Thomas M. Kündig, Yuk Law, Ken Yamamoto, N. Kamikawaji, Linda Burkly, Takehiko Sasazuki, Richard Flavell, Pamela S. Ohashi …

Journal of Experimental Medicine 180(5) 1911-1920 1994年11月1日
Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice

Ken Yamamoto, Yoshinori Fukui, Yukio Esaki, Takeshi Inamitsu, Tohm Sudo, Kazuaki Yamane, Nobuhiro Kamikawaji, Akinori Kimura, Takehiko Sasazuki

Journal of Experimental Medicine 180(1) 165-171 1994年7月1日
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

Senji Shirasawa, Masanori Furuse, Nobuhiko Yokoyama, Takehiko Sasazuki

Science 260(5104) 85-88 1993年
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

Mieko Okamoto, Masayuki Sasaki, Kenji Sugio, Chieko Sato, Takeo Iwama, Tatsuro Ikeuchi, Akira Tonomura, Takehiko Sasazuki, Michiko Miyaki

Nature 331(6153) 273-277 1988年
HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

Kenji Hirayama, Sho Matsushita, Ikuo Kikuchi, Masahiko Iuchi, Nobuo Ohta, Takehiko Sasazuki

Nature 327(6121) 426-430 1987年
Gene conversion-like events cause steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia.

Proc. Natl. Acad. Sci. USA., 84 : 8091-8094 1987
HLA and silicosis in Japan.

New Engl. J. Med., 319 : 1610, 1998
The A3 allele of the HLA-DQA1 locus in associated with susceptibility to type 1 diabetes in Japanese

Proc. Natl. Acad. Sci., 87 : 1094-1098, 1990
Association between the DRB 1 *08032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves Disease.

Ann. Intern. Med., 124 : 490-494, 1996
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus.

Immunity, 6 : 401-410, 1997
Quantitative analysis of the T-cell repertoire by a single peptide/MHC complex.

J. Exp. Med., 187 : 1871-1883, 1998
Impact of oncogenes in tumor angiogenesis: Mutant K-ras upregulation of VEGF/VPF is necessary, but not suffrcient for tumorigenicity of human colorectal carcinoma cells.

Proc. Natl. Acad. Sci., U.S.A., 95 : 3609-3614,1998
Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor b chain.

J. Exp. Med., 188 : 897-907, 1998
Spontaneous clustering of Thy-1 antigens on CD4+ CD8+ thyrnocytes lacking TCR engagement by MHC/peptide complexes.

Eur. J. Immun., 29 : 403-412, 1999
Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-ras signaling pathway in human colon cancer cells.Cancer Res., 60:6886-6889, 2000 Fukui Y, et al. : Diversity of T cell repertoire shaped by a single peptide・・・

Proc. Natl. Acad. Sci. USA, 97 : 13760-13765, 2000

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所属学協会

11