論文

査読有り
2006年8月

Susceptibility to colon carcinogenesis in C3H <-> C57BL/6 chimeric mice reflects both tissue microenvironment and genotype

CANCER LETTERS
  • Tetsuya Tsukamoto
  • ,
  • Masami Yamamoto
  • ,
  • Hiroko Fukami
  • ,
  • Akemi Yoshikawa
  • ,
  • Hirold Sakai
  • ,
  • Akihiro Hirata
  • ,
  • Moriaki Kusakabe
  • ,
  • Masae Tatematsu

239
2
開始ページ
205
終了ページ
211
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.canlet.2005.08.004
出版者・発行元
ELSEVIER IRELAND LTD

Considerable rodent strain differences have been documented with regard to susceptibility to colon carcinogens. To clarify mechanisms, chimeras of susceptible strain C3H and relatively resistant strain C57BL/6N (B6) mice were exposed to a colonotropic carcinogen, 1,2-dimethylhydrazine (DMH) and tumor incidence and multiplicity were assessed. In the chimeras, incidence was as high as the C3H level. Multiplicity of lesions of B6 cells was also increased (P < 0.001), but maintenance of the strain difference. When tumor localization was analyzed, tumors of B6 genotype in chimeras demonstrated a greater spread of distribution than in the parental case. The chimeric environment may thus stimulate tumor initiation but cell autonomous suppressive factors may be retained. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1016/j.canlet.2005.08.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16168562
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000239754400006&DestApp=WOS_CPL