論文

査読有り
2006年7月

Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis

CANCER LETTERS
  • Akihiro Hirata
  • ,
  • Tetsuya Tsukamoto
  • ,
  • Masarni Yamamoto
  • ,
  • Hiroki Sakai
  • ,
  • Tokuma Yanai
  • ,
  • Toshiaki Masegi
  • ,
  • Lawrence A. Donehower
  • ,
  • Masae Tatematsu

238
2
開始ページ
271
終了ページ
283
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.canlet.2005.07.022
出版者・発行元
ELSEVIER IRELAND LTD

To elucidate which is the major determinant of susceptibility of p53 deficient mice, the carcinogen or the target organ, N-bis(2-hydroxypropyl)nitrosamine was administered to induce tumors multi-organs. In a 15-week experiment. the incidences of both lung and hepatic vascular tumors were found to be significantly higher in p53 nullizygous (-/-) than in heterozygous (+/-) and wild-type (+/+) mice, indicating universal susceptibility of p53 (-/-) mice. In a 40-week experiment, p53 (+/-) mice showed increased susceptibility only with regard to vascular tumors, coinciding with significantly more frequent (60%) p53 gene mutations, in comparison with lung tumors with their low Mutation rate (10.8%) (P < 0.005). These results indicate that the target organ may be a more important factor than the carcinogen in determining susceptibility of p53 mice. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1016/j.canlet.2005.07.022
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16150539
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000238904400013&DestApp=WOS_CPL