- ELSEVIER IRELAND LTD
To elucidate which is the major determinant of susceptibility of p53 deficient mice, the carcinogen or the target organ, N-bis(2-hydroxypropyl)nitrosamine was administered to induce tumors multi-organs. In a 15-week experiment. the incidences of both lung and hepatic vascular tumors were found to be significantly higher in p53 nullizygous (-/-) than in heterozygous (+/-) and wild-type (+/+) mice, indicating universal susceptibility of p53 (-/-) mice. In a 40-week experiment, p53 (+/-) mice showed increased susceptibility only with regard to vascular tumors, coinciding with significantly more frequent (60%) p53 gene mutations, in comparison with lung tumors with their low Mutation rate (10.8%) (P < 0.005). These results indicate that the target organ may be a more important factor than the carcinogen in determining susceptibility of p53 mice. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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