Papers

Peer-reviewed
5 2002

Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea

CANCER LETTERS
  • M Yamamoto
  • ,
  • C Furihata
  • ,
  • T Ogiu
  • ,
  • T Tsukamoto
  • ,
  • K Inada
  • ,
  • K Hirano
  • ,
  • M Tatematsu

Volume
179
Number
2
First page
121
Last page
132
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/S0304-3835(02)00013-7
Publisher
ELSEVIER SCI IRELAND LTD

Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6 +/- 9.9%) in the BALB and lowest in the ICR (12.3 +/- 5.7%) mice (P < 0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P < 0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells, Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors, In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains. (C) 2002 Elsevier Science Ireland Ltd, All rights reserved.

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Link information
DOI
https://doi.org/10.1016/S0304-3835(02)00013-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11888666
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175320300002&DestApp=WOS_CPL