服部俊治 (Shunji Hattori) - マイポータル

基本情報

所属: 株式会社ニッピバイオマトリックス研究所顧問

学位: 医学博士(東京医科歯科大学)

J-GLOBAL ID: 200901090609899724
researchmap会員ID: 0000034754

外部リンク: http://www.jilr.or.jp

研究キーワード

研究分野

経歴

2018年7月 - 現在

ニッピバイオマトリックス研究所顧問
2016年 - 現在

株式会社マトリクソーム取締役
2016年 - 現在

一般財団法人日本皮革研究所
1996年 - 現在

財）日本皮革研究所主任研究員
2008年7月 - 2018年8月

ニッピバイオマトリックス研究所所長
1990年 - 2006年

（株）ニッヒ・バイオマトリックス研究所研究員
1990年 - 1993年

その間 1990-1993 米国フレッドハッチンソン癌研究客員研究員
1984年 - 1989年

東京医科歯科大学難治疾患研究所助手

学歴

委員歴

2019年 - 現在

東京都皮革技術センター推進協議会委員
- 2016年

マトリックス研究会運営委員
New York Academy of Science Active member
日本総合組織学会監事

受賞

論文

141

Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models

Panwen Liu, Chenkang Wang, Wenhui Chen, Yu Kang, Weiwei Liu, Zhiyue Qiu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Phytomedicine 2023年1月
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.

Yanfang Gao, Kai Ma, Yu Kang, Weiwei Liu, Xiaoling Liu, Xinyu Long, Toshihiko Hayashi, Shunji Hattori, Kazunori Mizuno, Hitomi Fujisaki, Takashi Ikejima

Biochimica et biophysica acta. Molecular and cell biology of lipids 1867(9) 159181-159181 2022年9月
The Thermal Stability of the Collagen Triple Helix Is Tuned According to the Environmental Temperature

Kazunori K. Fujii, Yuki Taga, Yusuke K. Takagi, Ryo Masuda, Shunji Hattori, Takaki Koide

International Journal of Molecular Sciences 23(4) 2040-2040 2022年2月12日
IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells

Yingying Zhu, Shuaigao Chen, Weiwei Liu, Fanxing Xu, Jingyu Lu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

CONNECTIVE TISSUE RESEARCH 2022年1月
Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration.

Xiaoling Liu, Er Zu, Xinyu Chang, Xiaowei Ma, Ziqi Wang, Xintong Song, Xiangru Li, Qing Yu, Ken-Ichiro Kamei, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima, Dan Ohtan Wang

Disease models & mechanisms 14(12) 2021年12月1日
Collagen molecular phenotypic switch between non-neoplastic and neoplastic canine mammary tissues

Masahiko Terajima, Yuki Taga, Becky K. Brisson, Amy C. Durham, Kotaro Sato, Katsuhiro Uzawa, Tomoaki Saito, Shunji Hattori, Karin U. Sørenmo, Mitsuo Yamauchi, Susan W. Volk

Scientific Reports 11(1) 2021年12月
Collagens I and V differently regulate the proliferation and adhesion of rat islet INS-1 cells through the integrin β1/E-cadherin/β-catenin pathway

Yingying Zhu, Shuaigao Chen, Weiwei Liu, Luxin Zhang, Fanxing Xu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Connective Tissue Research 62(6) 658-670 2021年11月2日
Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation

Xiumin Liu, Wenhui Chen, Chenkang Wang, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Physiology & Behavior 241 113593-113593 2021年11月
Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy

Xiumin Liu, Weiwei Liu, Chenkang Wang, Yinzhe Chen, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Physiology & Behavior 239 113510-113510 2021年10月
Collagen type I enhances cell growth and insulin biosynthesis in rat pancreatic cells

Yingying Zhu, Weiwei Liu, Shuaigao Chen, Fanxing Xu, Luxin Zhang, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Journal of Molecular Endocrinology 67(3) 135-148 2021年10月1日
Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson’s Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus

Xiumin Liu, Chenkang Wang, Weiwei Liu, Siaoyu Song, Jianing Fu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Neurochemical Research 46(9) 2317-2332 2021年9月
The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells

Kentaro Ide, Sanai Takahashi, Keiko Sakai, Yuki Taga, Tomonori Ueno, David Dickens, Rosalind Jenkins, Francesco Falciani, Takako Sasaki, Kazuhiro Ooi, Shuichi Kawashiri, Kazunori Mizuno, Shunji Hattori, Takao Sakai

Journal of Biological Chemistry 297(1) 100819-100819 2021年7月
In-depth correlation analysis demonstrates that 4-hydroxyproline at the Yaa position of Gly-Xaa-Yaa repeats dominantly stabilizes collagen triple helix

Yuki Taga, Keisuke Tanaka, Shunji Hattori, Kazunori Mizuno

Matrix Biology Plus 100067-100067 2021年5月
DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells

Can Li, Weiwei Liu, Fang Wang, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Molecular Immunology 131 180-190 2021年3月
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors

Weiwei Liu, Fang Wang, Can Li, Wuxiyar Otkur, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Satoshi Onodera, Takashi Ikejima

Journal of Photochemistry and Photobiology B: Biology 216 112147-112147 2021年3月
Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression.

Xinyu Long, Yanfang Gao, Weiwei Liu, Xiaoling Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Takashi Ikejima

Molecular and cellular biochemistry 474(1-2) 243-261 2020年11月
Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro.

Xiao-Yu Song, Rong-Hua Li, Wei-Wei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima

Toxicology in vitro : an international journal published in association with BIBRA 70 105047-105047 2020年10月30日
がん幹細胞とiPS

畑隆一郎, 陽暁艶, 前畑洋次郎, 服部俊治, 水野一乘

日本結合組織学会学術大会プログラム・抄録集 52回 61-61 2020年9月
The roles of histidine and tyrosine residues in the active site of collagenase in Grimontia hollisae

Kaichi Hayashi, Takeaki Ikeuchi, Ryo Morishita, Jun Qian, Kenji Kojima, Teisuke Takita, Keisuke Tanaka, Shunji Hattori, Kiyoshi Yasukawa

The Journal of Biochemistry 2020年5月9日査読有り
Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells

Lingling Si, Jianing Fu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Satoshi Onodera, Takashi Ikejima

Archives of Biochemistry and Biophysics 685 108284-108284 2020年5月