Hiroshi Kido

Profile Information

Affiliation: Professor, The Institute for Enzyme Research, Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima

Degree: Ph.D(The University of Tokushima)

Researcher number: 50144978
J-GLOBAL ID: 200901097884197254
researchmap Member ID: 0000036999

Research Interests

Research Areas

Research History

1991 - 1995

The University of Tokushima
1991 - 1995

Associate Professor of Tokushima University
1995

- 徳島大学教授
1995

- Professor of Tokushima University
1981 - 1991

The University of Tokushima
1981 - 1991

Assistant Professor of Tokushima University

Education

- 1977

The University of Tokushima
- 1977

Graduate School of Medicine, The University of Tokushima
- 1973

School of Medicine, Hirosaki University
- 1973

School of Medicine, Hirosaki University

Committee Memberships

Jul, 2003 - Present

理事、評議員, 日本病態プロテアーゼ学会
- Present

理事、評議員, 日本界面医学界
Jul, 2009 - Aug, 2011

President, International Proteolysis Society
Jul, 2002 - Aug, 2005

Vice President, International Proteolysis Society
2002

Vice President, International Proteolysis Society
1993

理事、評議員、永年会員, 日本生化学会

Papers

182

Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity

Etsuhisa Takahashi, Takako Sawabuchi, Tetsuya Homma, Yosuke Fukuda, Hironori Sagara, Takeshi Kinjo, Kaori Fujita, Shigeru Suga, Takashi Kimoto, Satoko Sakai …

Viruses, 15(8) 1662-1662, Jul 30, 2023
Anti-influenza activity of povidone-iodine-integrated materials.

Masaki Shoji, Kenta Ichihashi, Nongluk Sriwilaijaroen, Haruka Mayumi, Shinji Morikane, Etsuhisa Takahashi, Hiroshi Kido, Yasuo Suzuki, Kazuyoshi Takeda, Takashi Kuzuhara

Biological & pharmaceutical bulletin, Jun 23, 2023
Induction of systemic, mucosal, and cellular immunity against SARS‐CoV‐2 in mice vaccinated by trans‐airway with a S1 protein combined with a pulmonary surfactant‐derived adjuvant SF‐10

Takashi Kimoto, Satoko Sakai, Keiko Kameda, Ryoko Morita, Etsuhisa Takahashi, Yasuo Shinohara, Hiroshi Kido

Influenza and Other Respiratory Viruses, 17(3), Mar 9, 2023
Induction of systemic, mucosal, and cellular immunity against SARS‐CoV‐2 in mice vaccinated by trans‐airway with a S1 protein combined with a pulmonary surfactant‐derived adjuvant SF‐10

Takashi Kimoto, Satoko Sakai, Keiko Kameda, Ryoko Morita, Etsuhisa Takahashi, Yasuo Shinohara, Hiroshi Kido

Influenza and Other Respiratory Viruses, 17(3), Mar 9, 2023
A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring.

Keiko Kameda, Etsuhisa Takahashi, Takashi Kimoto, Ryoko Morita, Satoko Sakai, Mizuho Nagao, Takao Fujisawa, Hiroshi Kido

Nutrients, 15(3), Feb 2, 2023
Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells

Hideyuki Hara, Junji Chida, Keiji Uchiyama, Agriani Dini Pasiana, Etsuhisa Takahashi, Hiroshi Kido, Suehiro Sakaguchi

Scientific Reports, 11(1), Dec, 2021
Electrochemical enzyme-based blood ATP and lactate sensor for a rapid and straightforward evaluation of illness severity

Keine Nishiyama, Ryohei Mizukami, Shizuka Kuki, Akihiko Ishida, Junji Chida, Hiroshi Kido, Masatoshi Maeki, Hirofumi Tani, Manabu Tokeshi

Biosensors and Bioelectronics, 198 113832-113832, Nov, 2021 Peer-reviewed
肺サーファクタント由来人工合成粘膜アジュバントSF-10は、乳幼児期に抗インフルエンザ長期免疫記憶を誘導できる経口粘膜アジュバントである

木本貴士, 堺聡子, 亀田桂子, 森田涼子, 高橋悦久, 木戸博

日本肺サーファクタント・界面医学会雑誌, 52 32-33, Oct, 2021
肺サーファクタント由来人工合成アジュバントSF10混合インフルエンザワクチン経鼻投与のインフルエンザ感染重症化予防効果とアレルギー発生リスクの解析

木本貴士, 堺聡子, 亀田桂子, 森田涼子, 高橋悦久, 木戸博

日本肺サーファクタント・界面医学会雑誌, 51 25-26, Mar, 2021
Cellular and Biochemical Pathogenic Processes in Severe Influenza Virus Infection: How Does Cytokine Storm Play a Role?

Hiroshi Kido, Takashi Kimoto, Etsuhisa Takahashi

Respiratory Disease Series: Diagnostic Tools and Disease Managements, 37-46, 2021
A novel aqueous extract from rice fermented with Aspergillus oryzae and Saccharomyces cerevisiae possesses an anti-influenza A virus activity.

Masaki Shoji, Minami Sugimoto, Kosuke Matsuno, Yoko Fujita, Tomohiro Mii, Satomi Ayaki, Misa Takeuchi, Saki Yamaji, Narue Tanaka, Etsuhisa Takahashi …

PloS one, 16(1) e0244885, 2021
Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D.

Masaki Shoji, Tomoyuki Esumi, Narue Tanaka, Misa Takeuchi, Saki Yamaji, Mihiro Watanabe, Etsuhisa Takahashi, Hiroshi Kido, Masayuki Yamamoto, Takashi Kuzuhara

PloS one, 16(3) e0248960, 2021
加熱鶏卵アレルギー児におけるIgE抗体親和性の診断能についての検討

齋藤麻耶子, 佐藤未織, 山本貴和子, 多田仁美, 苛原誠, 松本健治, 朴慶純, 木戸博, 大矢幸弘

日本小児アレルギー学会誌, 34(4) 505-505, Sep, 2020
加熱鶏卵アレルギー児におけるIgE抗体親和性の診断能についての検討

齋藤麻耶子, 佐藤未織, 山本貴和子, 多田仁美, 苛原誠, 松本健治, 朴慶純, 木戸博, 大矢幸弘

日本小児アレルギー学会誌, 34(4) 505-505, Sep, 2020
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.

Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda …

PLoS pathogens, 16(8) e1008823, Aug, 2020
A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children

Haruka Hishiki, Tadaomi Kawashima, Noriko M. Tsuji, Naho Ikari, Ryo Takemura, Hiroshi Kido, Naoki Shimojo

Nutrients, 12(7) 1989-1989, Jul 3, 2020 Peer-reviewed
Diagnostic performance of IgE avidity for hen's egg allergy in young infants

Miori Sato, Kiwako Yamamoto-Hanada, Hitomi Tada, Makoto Irahara, Mayako Saito-Abe, Kenji Matsumoto, Kyongsun Pak, Hiroshi Kido, Yukihiro Ohya

The Journal of Allergy and Clinical Immunology: In Practice, 8(7) 2417-2420.e6, Jul, 2020 Peer-reviewed
Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells

Motohiro Nonaka, Shogo Matsumoto, Bruce Yong Ma, Hiroshi Kido, Nana Kawasaki, Nobuko Kawasaki, Toshisuke Kawasaki

Applied Sciences, 10(8) 2687-2687, Apr 13, 2020 Peer-reviewed
Ovomucoid-specific IgG4 level in cord blood associates negatively with later sensitization.

Makoto Irahara, Wakako Shinahara, Mayumi Sugimoto, Yukiko Ogawa, Keiji Shitsukawa, Kenji Kubota, Yukihiro Ohya, Hirohisa Saito, Shoji Kagami, Hiroshi Kido

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 30(8) 857-860, Dec, 2019 Peer-reviewed
Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice

E. Takahashi, T. Sawabuchi, T. Kimoto, S. Sakai, H. Kido

Journal of Dairy Science, 102(11) 9559-9569, Nov, 2019 Peer-reviewed

Misc.

314

加熱鶏卵アレルギー児におけるIgE抗体親和性の診断能についての検討

齋藤麻耶子, 佐藤未織, 山本貴和子, 多田仁美, 苛原誠, 松本健治, 朴慶純, 木戸博, 大矢幸弘

日本小児アレルギー学会誌(Web), 34(4), 2020
肺サーファクタント由来人工合成粘膜アジュバントSF‐10を利用した経鼻接種インフルエンザワクチン開発とその最新の知見

木本貴士, 木戸博

日本肺サーファクタント・界面医学会雑誌, 49 8-12, Oct, 2018
【予防接種アップグレード】その他生体成分粘膜アジュバントSF-10混合経鼻インフルエンザワクチンの展望

木本貴士, 木戸博

小児内科, 50(8) 1301-1304, Aug, 2018
【予防接種アップグレード】その他生体成分粘膜アジュバントSF-10混合経鼻インフルエンザワクチンの展望

木本貴士, 木戸博

小児内科, 50(8) 1301-1304, Aug, 2018
Development of novel therapeutics targeting host molecules for influenza

Chida J, Kido H, Sakaguchi S

Bio Clinica, 256(33) 52-55, 2018
ヒト肺サーファクタント類似人工合成粘膜アジュバントSF-10の細胞性免疫誘導効果

Kim Hyejin, 木本貴士, 高橋悦久, 堺聡子, 木戸博

日本生化学会大会プログラム・講演要旨集, 89回 [1P-339], Sep, 2016
宿主因子を標的とするバクチオールの抗インフルエンザ作用機序の解析

庄司正樹, 新垣優美絵, 江角朋之, 鴻海俊太郎, 山本千尋, 高橋悦久, 鈴木穣, 小西史朗, 木戸博, 葛原隆

日本薬学会年会要旨集(CD-ROM), 136th(3) ROMBUNNO.29AB‐PM271-193, Mar, 2016
Detection of Ovomucoid-Specific Low-Affinity IgE in 14-Month-Old Infants and Its Relationship with Eczema

Norio Kawamoto, Norio Kamemura, Hiroshi Kido, Toshiyuki Fukao

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2) AB173-AB173, Feb, 2016
Early Introduction of Egg for Infants with Atopic Dermatitis to Prevent Egg Allergy: A Double-Blind Placebo-Controlled Randomized Clinical Trial

Osamu Natsume, Shigenori Kabashima, Junko Nakasato, Kiwako Yamamoto-Hanada, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Eisuke Inoue, Wakako Shinahara …

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2) AB98-AB98, Feb, 2016
肺サーファクタント由来人工合成粘膜アジュバントSSFはマクロピノサイトーシスを介して抗原提示細胞への抗原取り込みを増強する

木本貴士, 金惠珍, 堺聡子, 高橋悦久, 木戸博

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P1188]-[2P1188], Dec, 2015
ヒト肺サーファクタント類似人工合成粘膜アジュバントSF-10の液性免疫及び細胞性免疫誘導効果

金惠珍, 木本貴士, 堺聡子, 高橋悦久, 木戸博

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P1189]-[2P1189], Dec, 2015
Clinical application of a highly sensitive allergen microarray which can monitor immune response by immunoglobulin class switching

64(5) 488-494, Nov, 2015
インフルエンザ感染におけるマクロライドの粘膜免疫増強効果 (特集マクロライド研究の新展開)

木戸博, 品原和加子, 高橋悦久

Respiratory medical research, 2(4) 229-233, Oct, 2014
Primary prevention of atopic dermatitis by skin care with emollient: a randomized controlled study

Y. Ohya, K. Morita, M. Narita, M. Futamura, M. Kondo, H. Kitazawa, K. Horimukai, H. Niizeki, K. Yoshida, M. Mozaki …

BRITISH JOURNAL OF DERMATOLOGY, 170(6) E9-E9, Jun, 2014
バクチオールによる抗インフルエンザ活性

庄司正樹, 江角朋之, 平尾昌哉, 新垣優美絵, 山本千尋, 高橋悦久, 木戸博, 葛原隆

日本薬学会年会要旨集, 134年会(3) 186-186, Mar, 2014
ウイルス性気道感染症における粘膜免疫の重要性 : インフルエンザ感染における粘膜免疫増強抗菌薬の併用効果 (特集鼻かぜ・喉かぜ診療のススメ) -- (ウイルス性かぜ症候群での抗菌薬の使用法)

木戸博, 高橋悦久, 堺聡子

感染と抗菌薬, 16(4) 361-367, Dec, 2013
肺サーファクタント由来人工合成粘膜アジュバントSF-10の感染防御効果と液性・細胞性免疫誘導効果の検討

木本貴士, 水野大, 堺聡子, 木戸博

日本肺サーファクタント・界面医学会雑誌, 44 59-61, Nov, 2013
インフルエンザ感染の重症化とその対策

Kido H, Yamane K, Chida J

22(2) 153-158, 2013
ヒト肺サーファクタント類似合成粘膜アジュバントSF-10による感染防御抗体の誘導効果とTh1/Th2応答の検討

木本貴士, 水野大, 堺聡子, 木戸博

日本生化学会大会プログラム・講演要旨集, 85回 3P-846, Dec, 2012
Mechanisms and treatments of severe influenza encephalopathy

22(6) 553-560, Dec, 2012

Books and Other Publications

Protease activity of influenza virus RNA polymerase PA subunit

International Congress Series 1219, 479-485 (2001), 2001

Professional Memberships

Works

蛋白チップの開発研究

2002
Development of Protein chip

2002

Research Projects

Allergy research prospect with new paradigm open up by the new sensitive allergen microarray

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

KIDO Hiroshi, TADA Hitomi, SHINAHARA Wakako
Study on the pathogenesis of severe influenza virus infection associated with cytokine storm and its effective treatment options

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KIDO Hiroshi, SAWAFUCHI Takako, IL INDALAO
Discovery of antigen-specific low affinity IgE in cord blood and the mechanisms of affinity maturation after birth for prevention of allergy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

KIDO Hiroshi
Screening of Flu Alarmin biomarkers of severe influenza virus infection and their confirmation in animal model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KIDO Hiroshi
The application to cancer vaccine of SSF that mimics pulmonary surfactant

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

MIZUNO Dai, KIDO Hiroshi
Pathogenicity of multiple organ failure induced by seasonal and highly pathogenic avian influenza virus infection and its therapeutic options

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KIDO Hiroshi, CHIDA Junji, MIZUNO Dai
The analysis of host response determining the severe influenza and HIV infection.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

YANO mihiro, KIDO Hiroshi, CHIDA Junji
Studies on real-time biomarker of illness severity inthe patients of critical illness and development of the diagnosis machine

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

KIDO Hiroshi, NISHIMURA Masaji, CHIDA Junji
Development of new therapeutics for a highly pathogenic influenza virus infection by inhibition of virus entry and multiplication

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2009 - 2011

KIDO Hiroshi, CHIDA Junji, YOUSSOUF Cisse, MIZUNO Dai
乳幼児食物アレルギーの診断と予防を可能にする臍帯血高感度診断デバイスの開発研究

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2010

木戸博
The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

YANO Mihiro, KIDO Hiroshi
食物アレルギーを血液と唾液から総合的に診断する新規ハイスループットデバイスの開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2007 - 2008

木戸博, 山田博司
ハイスループット食物アレルゲンエピトープ解析ダイヤモンドコーティングチップの開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2006 - 2006

木戸博, 山田博司
The role of anti-apoptotic factor 14-3-3 in HIV-1-associated dementia (HAD) pathology : The implication for the therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

YANO Mihiro, KIDO Hiroshi
Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

KUWAJIMA Masamichi, HIGUCHI Tomihiko, KUDO Kioshi, ISHIMURA Kazunori, SHINOHARA Yasuo, TSUKAGUCHI Hiroyasu
The relationship between a molecular chaperone and protease : The discovery of NDP kinase like activity of a chaperone, and degeneration diseases.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

YANO Mihiro, KIDO Hiroshi
Development of new influenza virus treatments based an the findings of triggering proteases for influenza virus entry into the cells and on the findings of protease-activating receptors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

KIDO Hiroshi, TASHIRO Masato, YAMADA Hiroshi, OKUMURA Yuushi, OUCHI Masato
Development of an immunocontraceptive DNA vaccine using sperm

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2000 - 2003

MAEGAWA Masahiko, IRAHARA Minoru, KIDO Hiroshi
Functional analysis of substrate-aggregation inhibition and unfoldase activities in the 20S proteasome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

INOUE Masahiro, HARA Tatsuru, YANO Mihiro, KIDO Hiroshi
Molecular chaperone activity of the 20S proteasome : Inhibitory activity of the substrate protein aggregation and unflodase activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2002

KIDO Hiroshi, OKUMURA Yuushi, YANO Mihiro

Industrial Property Rights

特願2018-161929 免疫寛容誘導剤及びアレルギー性疾患の治療又は予防剤

木戸博, 高橋悦久, 木本貴士, 堺聡子
特願2016-159824 抗インフルエンザ薬による獲得免疫機能低下抑制用組成物およびその製造方法

木戸博, 高橋悦久
特願2016-097337 アレルギー発症リスクを予測するためのデータを収集する方法

木戸博, 苛原誠, 鈴木宏一
特許第5804278 粘膜ワクチン

木戸博, 水野大
特許第5473899 合成ペプチドを含有する抗原薬物ビークルとこれを用いる粘膜ワクチン

木戸博, 水野大, 武井恒知
特許特許第5028627号 IgA抗体の選択的産生からIgA及びIgG両抗体産生への切換えを可能にする抗原薬物ビークルとこれを用いる経鼻・粘膜ワクチン

木戸博, 水野大
特許第4843792号経粘膜及び経皮投与を可能にする抗原薬物ヴィークル、これを用いる粘膜免疫の誘導方法、粘膜ワクチン及びDDS

木戸博, 水野大

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