論文

国際誌
2016年8月

Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer.

Cancer medicine
  • Sasagu Kurozumi
  • Yuri Yamaguchi
  • Shin-Ichi Hayashi
  • Hiromi Hiyoshi
  • Tetsuji Suda
  • Tatsuyuki Gohno
  • Hiroshi Matsumoto
  • Hiroyuki Takei
  • Jun Horiguchi
  • Izumi Takeyoshi
  • Tetsunari Oyama
  • Masafumi Kurosumi
  • 全て表示

5
8
開始ページ
1873
終了ページ
82
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/cam4.780

The carboxyl terminus of the Hsc70-interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and play a role in the inhibition of tumor progression and invasion under experimental conditions. However, the impact of CHIP expression on the prognosis of breast cancer patients has not yet been established. In this study, using an immunohistochemical method, 272 patients with invasive breast cancer were assessed for the expression of CHIP (graded scores 0-3) and the statuses of biomarkers, such as estrogen receptor (ER), progesterone receptor (PgR), and HER2. The relationships between the statuses of CHIP and biomarkers as well as clinical features were also evaluated, and that between the expression of CHIP and patient prognosis was analyzed. We revealed that the strong expression of CHIP correlated with positive ER (P < 0.001), positive PgR (P < 0.001), and negative HER2 (P = 0.02). In postmenopausal patients, relapse-free survival (RFS) was significantly better in the high CHIP group than in the low CHIP group (P = 0.042). In addition, RFS and cancer-specific survival (CSS) were significantly better in patients with ER-positive/CHIP score 3 tumors than in those with ER-negative/CHIP score 0 tumors (RFS: P = 0.038, CSS: P = 0.0098). The methylation status of CHIP gene promoter did not always account for the down-regulation of its expression. In conclusion, the overexpression of CHIP is a potent prognostic factor of a good prognosis in ER-positive breast cancer patients in the postmenopausal phase.

リンク情報
DOI
https://doi.org/10.1002/cam4.780
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27334118
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971916
ID情報
  • DOI : 10.1002/cam4.780
  • PubMed ID : 27334118
  • PubMed Central 記事ID : PMC4971916

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