2004年12月
Long-term treatment effects of Pueraria mirifica phytoestrogens on parathyroid hormone and calcium levels in aged menopausal cynomolgus monkeys
JOURNAL OF REPRODUCTION AND DEVELOPMENT
- ,
- ,
- ,
- ,
- ,
- 巻
- 50
- 号
- 6
- 開始ページ
- 639
- 終了ページ
- 645
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1262/jrd.50.639
- 出版者・発行元
- SOCIETY REPRODUCTION & DEVELOPMENT-SRD
To determine the effect of Pueraria mirifica (PM) on serum parathyroid hormone (PTH) and calcium levels on aged menopausal monkeys (Macaca fascicularis), subjects were treated with 10, 100, or 1,000 mg/day of PM. Blood samples were collected every 5 days for 30,90, and 60 days during pretreatment, treatment, and post-treatment periods, respectively. Sera were assayed for PTH, estradiol, and calcium levels. PM-1,000 had the strongest effect on the decrease in PTH (0.001<P <= 0.05) and calcium levels (0.001<P< 0.03) during the treatment period. PTH levels remained low for the first 15 days of the post-treatment period (0.01:<Pless than or equal to0.05). PM-10 induced a significant decrease in PTH level on day 80 (P=0.02) during the treatment period and a significant decrease in calcium level on day 75 (P<0.01). There were no changes in serum PTH and calcium levels throughout the study period in the PM-100 group. Estradiol levels decreased significantly during the treatment period in all treatment groups. The results suggest that long-term treatment with 1,000 mg/day of PM decreases serum PTH and calcium in aged menopausal monkeys, indicating that PM ameliorates bone loss caused by estrogen deficiency.
- リンク情報
- ID情報
-
- DOI : 10.1262/jrd.50.639
- ISSN : 0916-8818
- J-Global ID : 200902249731392978
- Web of Science ID : WOS:000227489800005