Kazunori Anzai

Profile Information

Affiliation: Professor, Nihon Pharmaceutical University

Degree: Ph.D.(The University of Tokyo)

J-GLOBAL ID: 200901011979130740
researchmap Member ID: 0000040625

1979年4月〜 1986年3月名古屋市立大学薬学部助手
1983年10月〜 1985年3月米国ノースウエスタン大学博士研究員
1986年2月〜 1986年3月九州大学薬学部教務員
1986年4月〜 1993年6月九州大学薬学部助手
1993年7月〜 2001年3月科学技術庁放射線医学総合研究所主任研究官
1998年4月〜 2001年3月同サブグループリーダー
2001年4月〜 2010年3月独立行政法人放射線に学総合研究所チームリーダー
2005年12月〜 2010年3月千葉大学大学院客員教授を併任
2010年4月〜現在日本薬科大学教授

Research Interests

Research Areas

Education

- 1979

The University of Tokyo
- 1975

Faculty of Pharmaceutical Sciences, The University of Tokyo

Committee Memberships

Awards

Papers

150

Thermotropic Transition in the States of Proteins in Sarcoplasmic Reticulum Vesicles.

Yutaka Kirino, Kazunori Anzai, Hiroshi Shimizu, Shigeo Ohta, Mamoru Nakanishi, Masamichi Tsuboi

J. Biochem., 1181-1184, 1977 Peer-reviewed
Temperature-Induced Change in the Ca2+-dependent ATPase Activity and in the State of the ATPase Protein of Sarcoplasmic Reticulum Membrane.

Kazunori Anzai, Yutaka Kirino, Hiroshi Shimizu

J. Biochem., 84 815-821, 1978 Peer-reviewedLead author
Electron Spin Resonance Studies on the Interaction between Liposomal Membrane and Triton X-100.

Kazunori Anzai, Hideo Utsumi, Keizo Inoue, Shoshichi Nojima, Takao Kwan

Chem. Pharm. Bull., 28(6) 1762-1767, 1980 Peer-reviewedLead author
A Freeze-Fracture Study of the Aggregation State of Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum in Reconstituted Vesicles at Low and High Temperature.

Kazunori Anzai, Jiro Usukura, Hiroshi Shimizu, Eichi Yamada

J. Biochem., 89(5) 1403-1409, 1981 Peer-reviewed
Preparation and Molecular Stereochemistry of Fluoro(meso-tetraphenylporphinato)iron(III).

Kazunori Anzai, Keiichiro Hatano, Young Ja Lee, W. Robert Scheidt

Inorg. Chem., 20 2337-2339, 1981 Peer-reviewedLead author
Synthesis and Kinetic Investigation of the Atropisomerization of meso-Tetra(2-cyanophenyl)porphine.

Keiichiro Hatano, Kazunori Anzai, Tadashi Kubo, Shoko Tamai

Bull. Chem. Soc. Jpn., 54(11) 3518-3521, 1981 Peer-reviewed
筋小胞体Ca2+,Mg2+-ATPアーゼにおける水素-重水素交換反応に対するADPおよびAMPPNPの影響

安西和紀, 桐野豊, 清水博

The Journal of Biochemistry, 90(2) 349-354, Aug, 1981 Peer-reviewedLead author
The Crystal and Molecular Structure of Bis(methanol)--tetraphenyl-porphinato-manganese(III) Perchlorate-Methanol. A Molecular Structure Relevant to the Intermediate-Spin Six Coordinate Iron(III) Porphyrin.

Keiichiro Hatano, Kazunori Anzai, Youichi Iitaka

Bull. Chem. Soc. Jpn., 56(2) 422-427, 1983 Peer-reviewed
Preparation and Molecular Stereochemistry of Metalloporphyrin Complexes with Cyano Ligands. Cyano(pyridine)(meso-tetraphenylporphinato)iron(III) Hydrate and Cyano-(meso-tetraphenylporphinato)manganese(III) Chloroform Solvate.

W. Robert, Scheidt, Young Ja Lee, Walaipan Luangdilok, Kenneth J. Haller, Kazunori Anzai, Keiichiro Hatano

Inorg. Chem., 22 1516-1522, 1983 Peer-reviewed
Physicochemical Properties of the Atropisomers of meso-Tetra(o-pivalamidophenyl)porphyrin.

Kazunori Anzai, Keiichiro Hatano

Chem. Pharm. Bull., 32(4) 1273-1278, 1984 Peer-reviewedLead author
tetra(o-pivalamidophenyl)porphyrinのアトロプ異性体への亜鉛取り込みの動力学

安西和紀, 畑野研一郎

Chemical & Pharmaceutical Bulletin, 32(6) 2067-2072, Jun, 1984 Peer-reviewedLead author
A Kinetic Study of Thermal Rotational Isomerization of 5,10,15,20-Tetrakis(o-aminophenyl)porphyrin and 5,10,15,20-Tetrakis(o-pivaloyl-aminophenyl)porphyrin.

Keiichiro Hatano, Kazunori Anzai, Akemi Nishino, Keiko Fujii

Bull. Chem. Soc. Jpn., 58(12) 3653-3654, 1985 Peer-reviewed
Binding of Imidazoles and Pyridines to the Atropisomers of Zinc Tetra(o-pivalamidophenyl)porphyrin.

Kazunori Anzai, Takashi Hosokawa, Keiichiro Hatano

Chem. Pharm. Bull., 34 1865-1870, 1986 Peer-reviewedLead author
Transmembrane Electron Transfer as Catalyzed by Poly(ethylenimine)-Linked Manganese Porphyrins.

Thomas J. Dannhauser, Mamoru Nango, Naoto Oku, Kazunori Anzai, Paul A. Loach

J. Am. Chem. Soc., 108 5865-5871, 1986 Peer-reviewed
Rapid Determination of Internal Volumes of Membrane Vesicles with Electron Spin Resonance-Stopped Flow Technique.

Kazunori Anzai, Ken-Ichiro Higashi, Yutaka Kirino

Biochim. Biophys. Acta, 937 73-80, 1988 Peer-reviewedLead author
Cation Channels from Ciliary Membrane of Tetrahymena Reconstituted into Planar Lipid Bilayer. Comparison between the Channels from the Wild T. Thermophila and from Its Mutant Which Does Not Show Ciliary Reversal.

Chie Fujiwara, Kazunori Anzai, Yutaka Kirino, Seiji Nagao, Yoshinori Nozawa, Mihoko Takahashi

J. Biochem., 104(3) 344-348, 1988 Peer-reviewed
Change in intravesicular volume of liposomes by freeze-thaw treatment as studied by ESR stopped-flow technique.

Kazunori Anzai, Masami Yoshida, Yutaka Kirino

Biochim. Biophys. Acta, 1021 21-26, 1990 Peer-reviewedLead author
Measurement of Steady-State Ca2+-pump Current Caused by Purified Ca2+-ATPase of Sarcoplasmic Reticulum Incorporated into a Planar Bilayer Lipid Membrane.

Itsuo Nishie, Kazunori Anzai, Taibo Yamamoto, Yutaka Kirino

J. Biol. Chem., 265 2488-2491, 1990 Peer-reviewed
Formation of Ion Channels by Synthetic Basic Peptides in Planar Lipid Bilayer Membrane.

Kazunori Anzai, Hitomi Kadono, Mitsuyo Hamasuna, Sannamu Lee, Haruhiko Aoyagi, Yutaka Kirino

Biochim. Biophys. Acta, 1064 256-266, 1991 Peer-reviewedLead author
Interaction with Phospholipid Bilayers, Ion Channel Formation, and Antimicrobial Activity of Basic Amphipathic -Helical Model Peptides of Various Chain Lengths.

Yukio Agawa, Sannamu Lee, Shin Ono, Haruhiko Aoyagi, Motonori Ohno, Takako Taniguchi, Kazunori Anzai, Yutaka Kirino

J. Biol. Chem., 266 20218-20222, 1991 Peer-reviewed

Misc.

150

種々のlecithinliposomeに及ぼすTriton×100の影響

内海英雄, 安西和紀, 管孝男, 井上圭三, 野島庄七

日本薬学会年会要旨集, IV 83-83, Apr, 1975
筋小胞体膜蛋白の構造のゆらぎの温度依存性

安西和紀, 桐野豊, 清水博, 太田成男, 中西守, 坪井正道

日本生物物理学会年会講演予稿集, 16回 313-313, Sep, 1977
フリーズフラクチャー法による,低温と高温とにおける再構成中の筋小胞体ATPアーゼの集合状態の研究

安西和紀, 臼倉治郎, 清水博

The Journal of Biochemistry, 89(5) 1403-1409, May, 1981
テトラ(2-シアノフェニル)ポルフィリンの合成および回転異性化反応の速度

安西和紀

日本化学会年会(含連合討論会)化学関係学協会連合協議会研究発表会合同大会講演予稿集, 44秋季(II) 291-291, Oct, 1981
ピケットフェンスポルフィリンの4つの回転異性体への亜鉛のとり込み速度について

安西和紀

日本薬学会年会要旨集, 103年会 470-470, Mar, 1983
ポルフィリンとDNAとの相互作用

安西和紀

化学と工業, 36(12) 914-915, Dec, 1983
亜鉛テトラオルトピバルアミドフェニルポルフィリンの4つの回転異性体へのN-塩基の配位

安西和紀

日本薬学会年会要旨集, 106年会 698-698, Mar, 1986
脂質平面膜における塩基性合成ペプチドのイオンチャネル活性

安西和紀, 角野仁美, 浜砂光代

生体膜と薬物の相互作用シンポジウム講演要旨集, 10回 21-22, Nov, 1988
カルシウムチャネルとポンプの構造と生理作用骨格筋小胞体Ca2+ポンプの起電性新しい実験法による研究の新展開

安西和紀, 桐野豊

実験医学, 10(6) 663-668, Apr, 1992
超分子システム各論イオン輸送システム

桐野豊, 安西和紀

蛋白質・核酸・酵素, 38(7) 1187-1192, May, 1993
Measurement of Free Radicals in Living Mice by In Vivo ESR Spectroscopy : Measurement of Free Radicals in Living Mice by In Vivo ESR Spectroscopy

MIURA Yuri, ANZAI Kazunori, OZAWA Toshihiko

Journal of radiation research, 36(4) 284-284, 1995
生体膜の表と裏リン脂質の非対称分布とフリップ・フロップ

安西和紀

蛋白質・核酸・酵素, 40(16) 2418-2426, Dec, 1995
脳におけるニトロキシル還元反応に及ぼすX-線照射の影響

三浦ゆり, 安西和紀, 小沢俊彦

日本薬学会年会要旨集, 116年会(4) 187-187, Mar, 1996
筋小胞体Ca2+遊離チャネルのイオン透過性に対する活性酸素の影響脂質平面膜法による研究

小川国孝, 山本晴彦, 安西和紀, 小沢俊彦, 國安明彦, 中山仁

日本薬学会年会要旨集, 116年会(4) 182-182, Mar, 1996
バンドル化両親媒性陽イオン性モデルペプチドのイオンチャンネル活性

横山雅俊, 平倉穣, 桐野豊, 坂本清志, 青柳東彦, 安西和紀, 三原久和

日本薬学会年会要旨集, 116年会(4) 181-181, Mar, 1996
膜作用性ペプチドの構造と脂質二重層膜におけるイオンチャネル活性との関係についての平面膜法を用いた研究

安西和紀

薬学研究の進歩, (13) 9-21, Mar, 1997
平面脂質二分子膜を利用した活性酸素障害機序の研究

安西和紀

日本薬学会年会要旨集, 117年会(4) 117-117, Mar, 1997
生体に対する磁場の影響

安西和紀

ぶんせき, (278) 100-105, Feb, 1998
methoxycarbonyl-PROXYLを用いたラット脳の三次元ESRイメージング

安西和紀, 高橋千太郎, 有本豊子, 竹下啓蔵, 小澤俊彦, 増水章季, 河野雅弘, 森昭胤

磁気共鳴と医学, 11 51-54, Mar, 2000
白血病細胞株HL60とその変異株HP100における細胞内カルシウム動態の比較

安西和紀, Zhang Guo-Jiang

日本薬学会年会要旨集, 120年会(3) 127-127, Mar, 2000

Books and Other Publications

わかりやすい薬学系の物理学入門

小林, 賢, 金長, 正彦, 上田, 晴久, 安西, 和紀, 五十鈴川, 和人, 鈴木, 幸男, 八木, 健一郎

講談社, Sep, 2015 (ISBN: 9784061563131)
放射線の科学 : 生体影響および防御と除去

小沢, 俊彦, 安西, 和紀, 松本, 謙一郎

東京化学同人, Nov, 2012 (ISBN: 9784807907939)
フリーラジカル・活性酸素と酸化ストレス、「酸化ストレスの医学」

診断と治療社, 2008
脂質、「生物物理学ハンドブック」

朝倉書店, 2007
放射線障害と酸化ストレス、「別冊医学のあゆみ「酸化ストレスフリーラジカル医学生物学の最前線Ver.2」」

医歯薬出版, 2006
電子スピン共鳴分析法、「薬学の機器分析学」

廣川書店, 1997
シビレエイ電気器官シナプス前神経終末からのアセチルコリン遊離機構に関する研究

桐野, 豊, 安西, 和紀, 平嶋, 尚英

桐野豊, 1994
薬学系のためのMacintosh-科研費申請から構造活性相関の視覚化まで

講談社, 1994
モデル合成ペプチドを用いた平面膜法によるイオンチャネルの構造・活性相関の研究

安西, 和紀

[九州大学], Mar, 1993

Professional Memberships

Research Projects

Fundamental study on the generation of reactive oxygen species in water and their effects on biological constituents by the irradiation of cold atmospheric pressure plasma

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Anzai Kazunori
Basic Research for the Evaluation of Antioxidant Activity of Functional Food

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Anzai Kazunori, KUBOTA YOKO, TSUCHIDA KAZUNORI, TAKAJYO TOKUKO
Reaction Mechanism of new vitamin E analog for protecting radiation injuries

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

ANZAI Kazunori, MATSUMOTO Kenichiro, TAKATA Jiro
Radiobiological study of proton beams for optimization of therapeutic effects on brain tumors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

TSUBOI Koji, ANZAI Kazunori, TAKANO Shingo, SAKAE Takeji, MORITAKE Takashi, YASUOKA Kiyoshi, TERUMUNA Toshiyuki
放射線効果の向上に関する生物学的研究

放射線医学重点研究, 2006 - 2010
Biological studies on improvement of radiation therapy

0028 (Japanese Only), 2006 - 2010
Basic study for development of multi imaging system of redox-related information in tumors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

TAKESHITA Keizo, MASUMIZ Toshiki, OKAZAKI Shoko, ANZAI Kazunori, MASUMIZU Toshiki, OKAZAKI Shoko, ANZAI Kazunori
Visualization of Localization of 14C-labeled Lidocaine in Oral Tissue

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

MAMIYA Hideki, ICHINOHE Tatsuya, KANEKO Yuzuru, ANZAI Kazunori
マウスの学習障害および脳酸化ストレスに対する抗酸化剤の役割

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2005 - 2007

安西和紀, MANDA Kailash
Study on non-invasive measurement of biological redox for diagnosis of chronic diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

TAKESHITA Keizo, ANZAI Kazunori, IKOTA Nobuo, MASUMIZU Toshiki, OKAZAKI Shoko
Effect of hydroxyl radicals in treatment of malignant brain tumors by accelerated charged particles irradiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

TSUBOI Koji, TAKANO Shinngo, ANZAI Kazunori, ANDO Koichi
Development of new probes for medical imaging of cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

TAKESHITA Keizo, ANZAI Kazunori, UEDA Jun-ichi, OZAWA Toshihiko
Establishnent of In vivo ESR Imaging System for Oxidativte Stress in Brain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

ANZAI Kazunori, TAKESHITA Keizo
A Study on the Mechanism of Spin Clearance in In vivo ESR Measurement

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 1999

ANZI Kazunori
再構成イオンチャネル活性におよぼす平面膜リン脂質組成の影響

科学研究費助成事業一般研究(C), 一般研究(C), 日本学術振興会, 1995 - 1995

安西和紀
Phospholipid translocation in various bilayr membranes using radioactive phospholipid probes

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1993 - 1994

ANZAI Kazunori
Synthesis of Transmembrane Segment of A Single Spanning Protein, Isk, Forming Potassium Channel and Its Interaction with Phospholipid Bilayr

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1993 - 1994

LEE Sannamu, ANZAI Kazunori, NAGADOME Shigemi, SUGIHARA Gohsuke
Mechanism of the Release of Acetylcholine from Presynaptic Nerve Terminals Isolated from Electric Organ of Japanese Electric Ray

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B), Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1992 - 1993

KIRINO Yutaka
Synthetic Model Peptides for the Study of Structure-Activity Relationship of Ion Channels Using Planar Lipid Bilayer Technique

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1991 - 1992

ANZAI Kazunori, AOYAGI Haruhiko
Reconstitution of Ion Channels from Cardiac Sarcolemmal Membranes

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B), Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1989 - 1991

KIRINO Yutaka, HIRASHIMA Naohide, ANZAI Kazunori