NAKAGAWA Hidehiko

J-GLOBAL         Last updated: May 15, 2019 at 19:13
 
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Name
NAKAGAWA Hidehiko
E-mail
decophar.nagoya-cu.ac.jp
Affiliation
Nagoya City University
Section
Graduate School of Pharmaceutical Sciences, Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutial Sciences
Job title
Professor
Degree
Ph.D.

Research Areas

 
 

Education

 
1990
 - 
1995
Graduate School of Pharmaceutical Sciences, The University of Tokyo
 
1986
 - 
1990
Faculty of Pharmaceutical Sciences, The University of Tokyo
 

Awards & Honors

 
2014
Award for Scientific Promotion, Society for Free Radical Research Japan
 

Published Papers

 
Kunieda K, Kawaguchi M, Ieda N, Nakagawa H
Bioorganic & medicinal chemistry letters   29(7) 923-928   Apr 2019   [Refereed]
Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H
Bioorganic & medicinal chemistry letters   29(3) 353-356   Feb 2019   [Refereed]
Mitsuyasu Kawaguchi, Takuma Tani, Ryoma Hombu, Naoya Ieda, Hidehiko Nakagawa
Chemical Communications   54(73) 10371-10374   Jan 2018   [Refereed]
© The Royal Society of Chemistry. Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers...
Ieda N, Oka Y, Yoshihara T, Tobita S, Sasamori T, Kawaguchi M, Nakagawa H
Scientific reports   9(1) 1430   Feb 2019   [Refereed]
Islam MJ, Matsuo K, Menezes HM, Takahashi M, Nakagawa H, Kakugo A, Sada K, Tamaoki N
Organic & biomolecular chemistry   17(1) 53-65   Dec 2018   [Refereed]
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin Ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Keiko Imamura, Keiko Imamura, Haruhisa Inoue, Haruhisa Inoue, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Nature Communications   9    Dec 2018
© 2018 The Author(s). Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder. Despite its severity, there are no effective treatments because of the complexity of its pathogenesis. As one of the underlying mechanisms of Cu...
Kazuki Kunieda, Hiromasa Yamauchi, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
Bioorganic and Medicinal Chemistry Letters   28 969-973   Mar 2018
© 2018 Elsevier Ltd Peptidyl arginine deiminases (PADs) catalyze the post-translational deimination of peptidyl arginine residues to form citrulline residues. Aberrant citrullination of histones by one of the PAD isozymes, PAD4, is associated with...
Masato Sawada, Nobuhiko Ohno, Nobuhiko Ohno, Mitsuyasu Kawaguchi, Shih Hui Huang, Takao Hikita, Youmei Sakurai, Huy Bang Nguyen, Truc Quynh Thai, Yuri Ishido, Yutaka Yoshida, Hidehiko Nakagawa, Akiyoshi Uemura, Kazunobu Sawamoto, Kazunobu Sawamoto
EMBO Journal      Jan 2018   [Refereed]
© 2018 EMBO. Newborn neurons maintain a very simple, bipolar shape, while they migrate from their birthplace toward their destinations in the brain, where they differentiate into mature neurons with complex dendritic morphologies. Here, we report ...
Lue Sun, Takashi Moritake, Takashi Moritake, Kazuya Ito, Yoshitaka Matsumoto, Hironobu Yasui, Hidehiko Nakagawa, Aki Hirayama, Osamu Inanami, Koji Tsuboi
PLoS ONE   12    Apr 2017   [Refereed]
© 2017 Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre...
Hana Okuno, Naoya Ieda, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
Organic and Biomolecular Chemistry   15 2791-2796   Jan 2017
© 2017 The Royal Society of Chemistry. Nitric oxide (NO) has been known as a gaseous chemical mediator, which modulates several physiological functions. Spatial and temporal control of NO release facilitates further study and medical application o...
Mitsuyasu Kawaguchi, Shohei Ikegawa, Naoya Ieda, Hidehiko Nakagawa
ChemBioChem   17 1961-1967   Oct 2016   [Refereed]
© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Sirtuins (SIRTs) are a family of NAD + -dependent histone deacetylases. In mammals, dysfunction of SIRTs is associated with age-related metabolic diseases and cancers, so SIRT mo...
Naoya Ieda, Sota Yamada, Mitsuyasu Kawaguchi, Naoki Miyata, Hidehiko Nakagawa
Bioorganic and Medicinal Chemistry   24 2789-2793   Jun 2016   [Refereed]
© 2016 The Authors. Histone deacetylases (HDACs) are involved in epigenetic control of the expression of various genes by catalyzing deacetylation of ϵ-acetylated lysine residues. Here, we report the design, synthesis and evaluation of the (7-diet...
Yuji Hotta, Naoya Ieda, Ayako Fukamoto, Tomoya Kataoka, Yoshihiro Kawade, Yasuhiro Maeda, Hidehiko Nakagawa, Kazunori Kimura, Kazunori Kimura
Investigative and Clinical Urology   57 215-220   May 2016   [Refereed]
© The Korean Urological Association, 2016. Purpose: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, lightcontrollable nitric oxide (NO) releaser. Materials and Methods: Fifteen-week-o...
Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki, Takayoshi Suzuki
Journal of Medicinal Chemistry   59 1531-1544   Feb 2016
© 2015 American Chemical Society. Inhibition of lysine-specific demethylase 1 (LSD1), a flavin-dependent histone demethylase, has recently emerged as a new strategy for treating cancer and other diseases. LSD1 interacts physically with SNAIL1, a m...
Takuya Arai, Takuya Arai, Akiko Ohno, Mori Kazunori, Taeko Kakizawa, Hiroshi Kuwata, Toshihiko Ozawa, Motoko Shibanuma, Shuntaro Hara, Seiichi Ishida, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
Bioorganic and Medicinal Chemistry   24 4138-4143   Jan 2016
© 2016 Elsevier Ltd Two hallmarks of Alzheimer's disease (AD) observed in the brains of patients with the disease include oxidative injury and deposition of protein aggregates comprised of amyloid-β (Aβ) variants. To inhibit these toxic processes,...
Takuya Arai, Takuya Arai, Akiko Ohno, Kazunori Mori, Hiroshi Kuwata, Mirei Mizuno, Kohei Imai, Shuntaro Hara, Motoko Shibanuma, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
Bioorganic and Medicinal Chemistry Letters   26 5468-5471   Jan 2016
© 2016 Elsevier Ltd Amyloid-β (Aβ) deposition and oxidative stress observed in the brains of patients with Alzheimer's disease (AD) are important targets for therapeutic intervention. In this study, we conjugated the antioxidants caffeic acid (CA)...
Kitamura K, Kawaguchi M, Ieda N, Miyata N, Nakagawa H
ACS Chem. Biol.   11 1271-1278   2016   [Refereed]
Hidehiko Nakagawa, Suguru Seike, Masatoshi Sugimoto, Naoya Ieda, Mitsuyasu Kawaguchi, Takayoshi Suzuki, Naoki Miyata
Bioorganic and Medicinal Chemistry Letters   25 5619-5624   Dec 2015
© 2015 The Authors. Published by Elsevier Ltd. Pin1 is a peptidyl prolyl isomerase that specifically catalyzes cis-trans isomerization of phosphorylated Thr/Ser-Pro peptide bonds in substrate proteins and peptides. Pin1 is involved in many importa...
Miriam M. Cortese-Krott, Gunter G.C. Kuhnle, Alex Dyson, Bernadette O. Fernandez, Marian Grman, Jenna F. DuMond, Mark P. Barrow, George McLeod, Hidehiko Nakagawa, Karol Ondrias, Péter Nagy, S. Bruce King, Joseph E. Saavedra, Larry K. Keefer, Mervyn Singer, Malte Kelm, Anthony R. Butler, Martin Feelisch
Proceedings of the National Academy of Sciences of the United States of America   112    Aug 2015
Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H 2 S) signaling pathways are intimately intertwined, with mutual attenuation or potentiation of biological responses in the cardiovascular system and elsewhere. The chemi...
Ieda N, Hishikawa K, Eto K, Kitamura K, Kawaguchi M, Suzuki T, Fukuhara K, Miyata N, Furuta T, Nabekura J, Nakagawa H
Bioorganic & medicinal chemistry letters      Jun 2015   [Refereed]

Misc

 
Nakagawa H
Chemical record (New York, N.Y.)   18(12) 1708-1716   Dec 2018   [Refereed]
Hidehiko Nakagawa
Journal of Clinical Biochemistry and Nutrition   58 1   Jan 2016
Hidehiko Nakagawa
Yakugaku Zasshi   136 29-35   Jan 2016
© 2016 The Pharmaceutical Society of Japan. Nitric oxide (NO) is historically well known as a toxic gas but now recognized as a physiological cellular mediator acting at very low concentrations. It is biosynthesized within the body, and modulates ...
Hidehiko Nakagawa
Journal of Clinical Biochemistry and Nutrition   58 2-6   Jan 2016
© 2016 JCBN. Photocontrollable nitric oxide (NO)-releasing compounds, or caged NOs, are very useful to expose cells or tissues to NO in a spatiotemporally well-controlled manner, e.g., for precise investigations of biological responses to NO and N...
Hidehiko Nakagawa
Folia Pharmacologica Japonica   147 294-298   Jan 2016
Hidehiko Nakagawa
Chemical and Pharmaceutical Bulletin   64 1249-1255   Jan 2016
© 2016 The Pharmaceutical Society of Japan. Nitric oxide (NO) is a gas that plays various roles in physiological signal transduction, for example, in vasodilation, neural transmission, and biodefence. Recently, other gaseous signal mediators such ...
Hidehiko Nakagawa
Drug Delivery System   31 127-134   Jan 2016
© 2016, Japan Society of Drug Delivery System. All rights reserved. Nitric oxide(NO) is now recognized as an endogenous signaling molecule involved in various physiological events such as vasodilation. Since NO is a gaseous molecule and has a shor...
Nakagawa H
Journal of inorganic biochemistry   118 187-190   Jan 2013   [Refereed]
Nakagawa H
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society   25(2) 195-200   Aug 2011   [Refereed]
Hishikawa K, Nakagawa H, Miyata N
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   131(3) 317-324   Mar 2011   [Refereed]
Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Katsumi Doh-ura, Takayoshi Suzuki, Naoki Miyata
Journal of Medicinal Chemistry   51 1503   Mar 2008
Nakagawa H, Miyata N
Methods in molecular biology (Clifton, N.J.)   477 99-112   2008   [Refereed]
Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   63 1004-1015   Jan 2005
As part of our studies towards molecularly targeted cancer therapy, we developed novel non-hydroxamate histone deacetylase (HDAC) inhibitors. A series of compounds modeled after suberoylanilide hydroxamic acid (SAHA) was designed as follows: (i) s...