J-GLOBAL         Last updated: Dec 2, 2019 at 20:18
Nagoya City University
Graduate School of Pharmaceutical Sciences, Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutial Sciences
Job title

Research Areas



Graduate School of Pharmaceutical Sciences, The University of Tokyo
Faculty of Pharmaceutical Sciences, The University of Tokyo

Awards & Honors

Award for Scientific Promotion, Society for Free Radical Research Japan
Winner: NAKAGAWA Hidehiko

Published Papers

Yuhei Ohta, Hiroo Wakita, Mitsuyasu Kawaguchi, Naoya Ieda, Shigehiro Osada, Hidehiko Nakagawa
Bioorganic and Medicinal Chemistry Letters   29    Nov 2019
© 2019 Elsevier Ltd One of the regulatory mechanisms of epigenetic gene expression is the post-translational methylation of arginine residues, which is catalyzed by protein arginine methyltransferases (PRMTs). Abnormal expression of PRMT4/CARM1, o...
Mitsuyasu Kawaguchi, Xiang Han, Tomoka Hisada, Sayaka Nishikawa, Kuniyuki Kano, Naoya Ieda, Junken Aoki, Tatsuya Toyama, Hidehiko Nakagawa
Journal of Medicinal Chemistry   62 9254-9269   Oct 2019
© 2019 American Chemical Society. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that is involved in bone metabolism and insulin resistance, hydrolyzes 2′,3′-cGAMP (a STING ligand that promotes i...
Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
Journal of Medicinal Chemistry   62 5434-5452   Jun 2019
© 2019 American Chemical Society. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide-dependent histone deacetylases that serve as epigenetic regulators of many physiological processes. Recent studies have shown that in addition to ...
Kunieda K, Kawaguchi M, Ieda N, Nakagawa H
Bioorganic & medicinal chemistry letters   29(7) 923-928   Apr 2019   [Refereed]
Ieda N, Oka Y, Yoshihara T, Tobita S, Sasamori T, Kawaguchi M, Nakagawa H
Scientific reports   9(1) 1430   Feb 2019   [Refereed]
Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H
Bioorganic & medicinal chemistry letters   29(3) 353-356   Feb 2019   [Refereed]
Taniyuki Furuyama, Takashi Ishii, Naoya Ieda, Hajime Maeda, Masahito Segi, Masanobu Uchiyama, Hidehiko Nakagawa
Chemical Communications   55 7311-7314   Jan 2019
© The Royal Society of Chemistry 2019. Herein, we report the exceptionally red-shifted absorption of sulfur-substituted silicon(iv) phthalocyanines upon introduction of cationic axial ligands. The Q band was red-shifted to approximately 900 nm wit...
Naoya Ieda, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
Chemical and Pharmaceutical Bulletin   67 576-579   Jan 2019
© 2019 The Pharmaceutical Society of Japan Spatiotemporally controllable nitric oxide (NO) releasers are very attractive chemical tools for investigating the biological activities of NO, which is involved in the regulation of vasodilation, neurotr...
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin Ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Keiko Imamura, Keiko Imamura, Haruhisa Inoue, Haruhisa Inoue, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Nature Communications   9    Dec 2018
© 2018 The Author(s). Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder. Despite its severity, there are no effective treatments because of the complexity of its pathogenesis. As one of the underlying mechanisms of Cu...
Islam MJ, Matsuo K, Menezes HM, Takahashi M, Nakagawa H, Kakugo A, Sada K, Tamaoki N
Organic & biomolecular chemistry   17(1) 53-65   Dec 2018   [Refereed]
Kazuki Kunieda, Hiromasa Yamauchi, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
Bioorganic and Medicinal Chemistry Letters   28 969-973   Mar 2018
© 2018 Elsevier Ltd Peptidyl arginine deiminases (PADs) catalyze the post-translational deimination of peptidyl arginine residues to form citrulline residues. Aberrant citrullination of histones by one of the PAD isozymes, PAD4, is associated with...
Mitsuyasu Kawaguchi, Takuma Tani, Ryoma Hombu, Naoya Ieda, Hidehiko Nakagawa
Chemical Communications   54(73) 10371-10374   Jan 2018   [Refereed]
© The Royal Society of Chemistry. Nitroxyl (HNO) is a gaseous molecule with unique pharmacological functions distinct from those of nitric oxide. Because HNO is highly reactive with biological molecules, spatiotemporally controllable HNO releasers...
Masato Sawada, Nobuhiko Ohno, Nobuhiko Ohno, Mitsuyasu Kawaguchi, Shih Hui Huang, Takao Hikita, Youmei Sakurai, Huy Bang Nguyen, Truc Quynh Thai, Yuri Ishido, Yutaka Yoshida, Hidehiko Nakagawa, Akiyoshi Uemura, Kazunobu Sawamoto, Kazunobu Sawamoto
EMBO Journal      Jan 2018   [Refereed]
© 2018 EMBO. Newborn neurons maintain a very simple, bipolar shape, while they migrate from their birthplace toward their destinations in the brain, where they differentiate into mature neurons with complex dendritic morphologies. Here, we report ...
Lue Sun, Takashi Moritake, Takashi Moritake, Kazuya Ito, Yoshitaka Matsumoto, Hironobu Yasui, Hidehiko Nakagawa, Aki Hirayama, Osamu Inanami, Koji Tsuboi
PLoS ONE   12    Apr 2017   [Refereed]
© 2017 Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre...
Hana Okuno, Naoya Ieda, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa
Organic and Biomolecular Chemistry   15 2791-2796   Jan 2017
© 2017 The Royal Society of Chemistry. Nitric oxide (NO) has been known as a gaseous chemical mediator, which modulates several physiological functions. Spatial and temporal control of NO release facilitates further study and medical application o...
Mitsuyasu Kawaguchi, Shohei Ikegawa, Naoya Ieda, Hidehiko Nakagawa
ChemBioChem   17 1961-1967   Oct 2016   [Refereed]
© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Sirtuins (SIRTs) are a family of NAD + -dependent histone deacetylases. In mammals, dysfunction of SIRTs is associated with age-related metabolic diseases and cancers, so SIRT mo...
Naoya Ieda, Sota Yamada, Mitsuyasu Kawaguchi, Naoki Miyata, Hidehiko Nakagawa
Bioorganic and Medicinal Chemistry   24 2789-2793   Jun 2016   [Refereed]
© 2016 The Authors. Histone deacetylases (HDACs) are involved in epigenetic control of the expression of various genes by catalyzing deacetylation of ϵ-acetylated lysine residues. Here, we report the design, synthesis and evaluation of the (7-diet...
Yuji Hotta, Naoya Ieda, Ayako Fukamoto, Tomoya Kataoka, Yoshihiro Kawade, Yasuhiro Maeda, Hidehiko Nakagawa, Kazunori Kimura, Kazunori Kimura
Investigative and Clinical Urology   57 215-220   May 2016   [Refereed]
© The Korean Urological Association, 2016. Purpose: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, lightcontrollable nitric oxide (NO) releaser. Materials and Methods: Fifteen-week-o...
Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki, Takayoshi Suzuki
Journal of Medicinal Chemistry   59 1531-1544   Feb 2016
© 2015 American Chemical Society. Inhibition of lysine-specific demethylase 1 (LSD1), a flavin-dependent histone demethylase, has recently emerged as a new strategy for treating cancer and other diseases. LSD1 interacts physically with SNAIL1, a m...
Takuya Arai, Takuya Arai, Akiko Ohno, Kazunori Mori, Hiroshi Kuwata, Mirei Mizuno, Kohei Imai, Shuntaro Hara, Motoko Shibanuma, Masaaki Kurihara, Naoki Miyata, Hidehiko Nakagawa, Kiyoshi Fukuhara
Bioorganic and Medicinal Chemistry Letters   26 5468-5471   Jan 2016
© 2016 Elsevier Ltd Amyloid-β (Aβ) deposition and oxidative stress observed in the brains of patients with Alzheimer's disease (AD) are important targets for therapeutic intervention. In this study, we conjugated the antioxidants caffeic acid (CA)...


Nakagawa H
Chemical record (New York, N.Y.)   18(12) 1708-1716   Dec 2018   [Refereed]
Hidehiko Nakagawa
Journal of Clinical Biochemistry and Nutrition   58 1   Jan 2016
Hidehiko Nakagawa
Yakugaku Zasshi   136 29-35   Jan 2016
© 2016 The Pharmaceutical Society of Japan. Nitric oxide (NO) is historically well known as a toxic gas but now recognized as a physiological cellular mediator acting at very low concentrations. It is biosynthesized within the body, and modulates ...
Hidehiko Nakagawa
Journal of Clinical Biochemistry and Nutrition   58 2-6   Jan 2016
© 2016 JCBN. Photocontrollable nitric oxide (NO)-releasing compounds, or caged NOs, are very useful to expose cells or tissues to NO in a spatiotemporally well-controlled manner, e.g., for precise investigations of biological responses to NO and N...
Hidehiko Nakagawa
Folia Pharmacologica Japonica   147 294-298   Jan 2016
Hidehiko Nakagawa
Chemical and Pharmaceutical Bulletin   64 1249-1255   Jan 2016
© 2016 The Pharmaceutical Society of Japan. Nitric oxide (NO) is a gas that plays various roles in physiological signal transduction, for example, in vasodilation, neural transmission, and biodefence. Recently, other gaseous signal mediators such ...
Hidehiko Nakagawa
Drug Delivery System   31 127-134   Jan 2016
© 2016, Japan Society of Drug Delivery System. All rights reserved. Nitric oxide(NO) is now recognized as an endogenous signaling molecule involved in various physiological events such as vasodilation. Since NO is a gaseous molecule and has a shor...
Nakagawa H
Journal of inorganic biochemistry   118 187-190   Jan 2013   [Refereed]
Nakagawa H
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society   25(2) 195-200   Aug 2011   [Refereed]
Hishikawa K, Nakagawa H, Miyata N
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   131(3) 317-324   Mar 2011   [Refereed]
Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Katsumi Doh-ura, Takayoshi Suzuki, Naoki Miyata
Journal of Medicinal Chemistry   51 1503   Mar 2008
Nakagawa H, Miyata N
Methods in molecular biology (Clifton, N.J.)   477 99-112   2008   [Refereed]
Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   63 1004-1015   Jan 2005
As part of our studies towards molecularly targeted cancer therapy, we developed novel non-hydroxamate histone deacetylase (HDAC) inhibitors. A series of compounds modeled after suberoylanilide hydroxamic acid (SAHA) was designed as follows: (i) s...