Kazuhide Inoue

Profile Information

Affiliation: (University Professor), The Institute for Advanced Study, Kyushu University

Degree: Ph.D.

J-GLOBAL ID: 200901074396795037
researchmap Member ID: 0000041138

External link: http://210.233.60.66/~yakkou/

ATP受容体の生理機能、グリア-ニューロン相互作用、グリア細胞の病態生理機能などについて研究している。2003年 (Nature)、2005年(Nature)に、脊髄ミクログリアがシナプス伝達を変調し、それが神経障害性疼痛の主症状アロディニア(allodynia，異痛症) の発症メカニズムであることを発表して以来、「ミクログリアと疼痛」に関する発表論文数が指数関数的に増加し、世界的潮流となった。ごく最近、ミクログリアには悪玉ばかりでなく、あるサブセットは神経障害性疼痛治癒に貢献する善玉もいることを明らかにした (Science 2022)。中枢での疼痛制御にアストロサイトの重要性も新たに見いだし、過去には静的なグリア集団が実に多様に能動的に中枢機能を制御していることを明らかにしつつある。

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

Oct, 2020 - Present

University Professor, The Institute for Advanced Study, Kyushu University
Oct, 2014 - Sep, 2020

九州大学理事・副学長
Aug, 2011 - Mar, 2016

九州大学・創薬育薬最先端研究基盤センター長（併任）
May, 2009 - Mar, 2016

九州大学・主幹教授
Jan, 2005 - Sep, 2014

九州大学大学院薬学研究院・薬効解析学（現・薬理学）分野教授
Apr, 2010 - Mar, 2014

九州大学大学院・薬学研究院・研究院長
Apr, 2000 - Jan, 2005

九大大学院薬学研究院教授（兼任）
Apr, 1978 - Jan, 2005

国立衛生試験所薬理部配属
Apr, 1978

: Division of Pharmacology, National Institute of
Pharmaceutical Sciences, Kyushu University
Health Science

Education

Mar, 1975

九州大学大学院薬学研究科
Mar, 1973

School of Pharmaceutical Sciences, Kyushu University
Kyushu Univesrsity
Graduate School of Kyushu University

Major Papers

244

A spinal microglia population involved in remitting and relapsing neuropathic pain.

Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, Keiko Takanami, Kazuhide Inoue, Hirotaka Sakamoto, Yasuyuki Ohkawa, Takahiro Masuda …

Science (New York, N.Y.), 376(6588) 86-90, Apr, 2022
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.

Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Keita Kohno, Keisuke Koga, Ryuichi Katsuragi, Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane …

Nature neuroscience, 23(11) 1376-1387, Nov, 2020
Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen Tao, Taniguchi Wataru, Chen Qi-Yu, Tozaki-Saitoh Hidetoshi, Song Qian, Liu Ren-Hao, Koga Kohei, Matsuda Tsuyoshi, Kaito-Sugimura Yae, Wang Jian …

NATURE COMMUNICATIONS, 9(1), May 14, 2018 Peer-reviewed
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Inoue Kazuhide, Tsuda Makoto

NATURE REVIEWS NEUROSCIENCE, 19(3) 138-152, Mar, 2018 Peer-reviewed
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi Satoru, Kusunose Naoki, Taniguchi Marie, Akamine Takahiro, Kanado Yuki, Ozono Yui, Masuda Takahiro, Kohro Yuta, Matsunaga Naoya, Tsuda Makoto …

NATURE COMMUNICATIONS, 7, Oct 14, 2016 Peer-reviewed
Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda Takahiro, Ozono Yui, Mikuriya Satsuki, Kohro Yuta, Tozaki-Saitoh Hidetoshi, Iwatsuki Ken, Uneyama Hisayuki, Ichikawa Reiko, Salter Michael W, Tsuda Makoto …

NATURE COMMUNICATIONS, 7, Aug, 2016 Peer-reviewed
BK channels in microglia are required for morphine-induced hyperalgesia

Yoshinori Hayashi, Saori Morinaga, Jing Zhang, Yasushi Satoh, Andrea L. Meredith, Takahiro Nakata, Zhou Wu, Shinichi Kohsaka, Kazuhide Inoue, Hiroshi Nakanishi

NATURE COMMUNICATIONS, 7 11697, May, 2016 Peer-reviewed
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori-Hayashi Miho, Koga Keisuke, Tozaki-Saitoh Hidetoshi, Kohro Yuta, Toyonaga Honami, Yamaguchi Chiharu, Hasegawa Ayumi, Nakahara Takeshi, Hachisuka Junichi, Akira Shizuo …

NATURE MEDICINE, 21(8) 927-931, Aug, 2015 Peer-reviewed
Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain

Masuda Takahiro, Iwamoto Shosuke, Yoshinaga Ryohei, Tozaki-Saitoh Hidetoshi, Nishiyama Akira, Mak Tak W, Tamura Tomohiko, Tsuda Makoto, Inoue Kazuhide

NATURE COMMUNICATIONS, 5, May, 2014 Peer-reviewed
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio Nakaya, Mitsuru Tajima, Hidetaka Kosako, Takeo Nakaya, Akiko Hashimoto, Kenji Watari, Hiroaki Nishihara, Mina Ohba, Shiori Komiya, Naoki Tani …

NATURE COMMUNICATIONS, 4 1532, Feb, 2013 Peer-reviewed
UDP acting at P2Y(6) receptors is a mediator of microglial phagocytosis

Schuichi Koizumi, Yukari Shigemoto-Mogami, Kaoru Nasu-Tada, Yoichi Shinozaki, Keiko Ohsawa, Makoto Tsuda, Bhalchandra V. Joshi, Kenneth A. Jacobson, Shinichi Kohsaka, Kazuhide Inoue

NATURE, 446(7139) 1091-1095, Apr, 2007
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

NATURE, 438(7070) 1017-1021, Dec, 2005
P2X(4) receptors induced in spinal microglia gate tactile allodynia after nerve injury

M Tsuda, Y Shigemoto-Mogami, S Koizumi, A Mizokoshi, S Kohsaka, MW Salter, K Inoue

NATURE, 424(6950) 778-783, Aug, 2003

Misc.

232

Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies

Kazuhide Inoue

Journal of Pharmacological Sciences, 149(3) 73-80, Jul, 2022
Nociceptive signaling of P2X receptors in chronic pain states

Kazuhide Inoue

Purinergic Signalling, 17(1) 41-47, Mar, 2021
Role of the P2X4 receptor in neuropathic pain

Kazuhide Inoue

Current Opinion in Pharmacology, 47 33-39, Aug, 2019
A state-of-the-art perspective on microgliopathic pain

Kazuhide Inoue

Open Biology, 8(11), Nov 1, 2018
Transcription factor MAFB mediates activation of spinal microglia relating to neuropathic pain after peripheral nerve injury

H. Saitoh, J. Masuda, R. Kawada, C. Kojima, S. Yoneda, T. Masuda, M. Tsuda, K. Inoue

JOURNAL OF NEUROCHEMISTRY, 142 85-85, Aug, 2017
脊髄後角抑制性介在神経の急性的な抑制はモルヒネ抵抗性の自発的疼痛関連行動を引き起こす

古賀啓祐, 兼久賢章, 高露雄太, 齋藤秀俊, 井上和秀, 古江秀昌, 津田誠

Pain Research, 32(2) 120-120, Jun, 2017
Neuropharmacological Study of ATP Receptors, Especially in the Relationship between Glia and Pain

Kazuhide Inoue

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(5) 563-569, May, 2017
Purinergic signaling in microglia in the pathogenesis of neuropathic pain

Proceedings of the Japan Academy. Series. B, Physical and biological sciences, 93(4) 174-182, Apr, 2017
Glia functions in the neuropathic pain mechanism

66(6) 556-560, Nov, 2015
Role of STAT3-dependent reactive astrocytes in the spinal dorsal horn in chronic itch

M. Shiratori-Hayashi, K. Inoue, M. Tsuda

GLIA, 63 E352-E352, Aug, 2015
気管支喘息モデルマウスはミクログリア活性化とアロディニアを生じる

山崎亮, 王氷, 津田誠, 城戸瑞穂, 井上和秀, 吉良潤一

末梢神経, 25(2) 347-347, Dec, 2014
Spinal mechanism for chronic itch

Makoto Tsuda, Kazuhide Inoue

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 56P-56P, 2014
IRF5 directly regulates P2X4R(+) reactive state of microglia driving neuropathic pain

Takahiro Masuda, Shosuke Iwamoto, Ryohei Yoshinaga, Hidetoshi Tozaki-Saitoh, Akira Nishiyama, Tak W. Mak, Tadatsugu Taniguchi, Tomohiko Tamura, Makoto Tsuda, Kazuhide Inoue

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 124P-124P, 2014
Regulation of synaptic strength are controlled by circadian rhythm of cathepsin S expression in the microglia

Yoshinori Hayashi, Saoru Koyanagi, Naoki Kusunose, Ryo Okada, Zhou Wu, Hidetoshi Saitoh, Shinichi Kohsaka, Kazuhide Inoue, Shigehiro Ohodo, Hiroshi Nakanishi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 125P-125P, 2014
Contribution of bone marrow-derived cells to the population of spinal microglia after peripheral nerve injury

Daisuke Tomiyama, Makoto Tsuda, Kazuhide Inoue

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 147P-147P, 2014
Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans

Kazu Kobayakawa, Kazu Kobayakawa, Hiromi Kumamaru, Hiromi Kumamaru, Hirokazu Saiwai, Hirokazu Saiwai, Kensuke Kubota, Kensuke Kubota, Yasuyuki Ohkawa, Junji Kishimoto …

Science Translational Medicine, 6, Jan 1, 2014
Involvement of Glial Cells in Chronic Pain and Their Potentials for Therapeutic Targets

48(12) 1185-1190, Dec, 2013
第86回日本薬理学会年会市民公開講座 : 「難治性疼痛 : 心と痛みの関係について」を開催して

井上和秀

日本薬理學雜誌 = Folia pharmacologica Japonica, 141(6) 355, Jun 1, 2013
ATP release from keratinocytes is a Ca2+-dependent exocytosis via a vesicular nucleotide transporter, VNUT

K. Inoue, K. Fujishita, K. Shibata, R. Komatsu, Y. Imura, Y. Moriyama, S. Koizumi

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133 S115-S115, May, 2013
The Neuropharmacological Study for ATP Receptors Especially in Pain

133(10) 1035-1039, 2013

Professional Memberships

Research Projects

Drug discovery and research for regulation of chronic inflammation caused by microglial activation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

YAMASHITA Tomohiro, TSUDA Makoto, SAITOH Hidetoshi, Jose Caaveiro, INOUE Kazuhide
Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2018

IKENAKA Kazuhiro, ITO Kei, UEKI Takatoshi, OHKI Kenichi, KATO Takahiro, KANEMARU Kazunori, SHIMIZU Takeshi, TAKEBAYASHI Hirohide, TANAKA Kenji, HASHIOTO Kohichi, YAMAZAKI Yoshihiko, INOUE Kazuhide, OKABE Shigeo, OZAKI Norio, KANBA Shigenobu, KIRA Junichi, KOHSAKA Shinichi, FUKUYAMA Hidenao, BANNAI Hiroko, NAKASHIMA Kinichi, IMAI Hiroo, MATSUI Ko, TACHIKAWA Masanori, KAKEGAWA Wataru
Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

UEDA Tadashi, INOUE Kazuhide, TSUDA Makoto
Synaptic regulation by intracerebral microglia and chronic pain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2013 - Mar, 2018

Inoue Kazuhide
The role of glial cells in neuropathic pain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Inoue Kazuhide, SAITOH Hidetoshi
Comprehensive Brain Science Network

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

Kimura Minoru, Tanji Jun, Takada Masahiko, Nakamura Katsuki, Ohtsuka Toshihisa, Aoki Shigeki, Takao Hidemasa, Shimoji Keigo, Goto Masami, Yoshiura Takashi, Nakata Yasuhiro, Abe Osamu, Masumoto Tomohiko, Tokumaru Aya, Matsumura Akira, Kirino Eiji, Terada Hitoshi, Sato Noriko, Kasai Kiyoto, Hashimoto Ryota, Niwa Shin-ichi, Kato Tadafumi, Suzuki Michio, Shuji Iritani, Nemoto Kiyotaka, Tomita Hiroaki, Murayama Shigeo, Akatsu Hiroyasu, Takao Masaki, Saito Yuko, Bito Haruhiko, Yoshimura Yumiko, Matsuzaki Masanori, Furuta Toshiaki, Okado Haruo, Saito Izumu, Kaibuchi Kozo, Hasegawa Masato, Aiba Atsu, Shiina Nobuyuki, Igarashi Michihiro, Tomoki Nishioka, Watanabe Masahiko, Koike Masato, Sakagami Hiroyuki, Shigemoto Ryuichi, Fukazawa Yugo, Sakimura Kenji, Mori Hisashi, Mishina Masayoshi, Kobayashi Kazuto, Yanagawa Yuchio, Uemura Tadashi, Ishihara Takeshi, Nose Akinao, Iino Yuichi, Miyakawa Tsuyoshi, Takao Keizo, Mushiake Hajime, Katayama Norihiro, Tanaka Tetsu, Inoue Kazuhide, Okabe Shigeo, Kano Masanobu, Fujiyama Fumino, Isa Tadashi, Kageyama Ryoichiro, Fujita Ichiro, Yoshida Akira, Nishikawa Toru, Nukina Nobuyuki, Fukai Tomoki, Iwatsubo Takeshi, Yamamori Tetsuo, Okazawa Hitoshi, Tanaka Keiji, Kakigi Ryusuke, Tsuda Ichiro, Kitazawa Shigeru, Doya Kenji, Takahashi Ryosuke, Ikenaka Kazuhiro, Sobue Gen, Hasegawa Toshikazu, Ota Jun, Saitoe Minoru, Kadomatsu Kenji, Kida Satoshi, Manabe Toshiya, Tomita Taisuke, Iwata Atsushi, Murakami Ikuya, Tsutsui Ken-ichiro, Hanakawa Takashi, Hirai Hirokazu, Mima Tatsuya, Isomura Yoshikazu, Samejima Kazuyuki, Hoshi Eiji, Miyata Mariko, Yuzaki Michisuke, Tanaka Masaki, Fukata Masaki, Suzuki Kyoko, Kuba Hiroshi, Masu Masayuki, Kinoshita Makoto, Sugihara Izumi, Shirane Michiko, Yamamoto Nobuhiko, Nishijo Hisao, Nambu Atsushi, Takumi Toru, Yamashita Toshihide, Sakurai Takeshi, Tamamaki Nobuaki, Hata Yoshio, Harada Akihiro, Ozaki Norio, Sakai Katsuyuki, Kubo Yoshihiro, Nakazawa Takanobu, Tanaka Kenji, Takei Nobuyuki, Hitoshi Seiji, Takahiroa. Kato, Kato Fusao, Shirao Tomoaki, Taira Masato, Okano Hideyuki, Sekino Yuko, Okamoto Yasumasa, KOMATSU Hidehiko, Miyata Takaki, Takahashi Yoshiko, Nishida Shinya, Tominaga Makoto
Study on the development of molecules for depressing neuropathic pain based on tertiary structure of human P2X4 receptor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

UEDA Tadashi, ABE Yoshito, TANAKA Hiroyuki, SHIROISH Mitsunori, SAITO Hidetoshi, INOUE Kazuhide, TSUDA Makoto
Research for the mechanism of the expression of neuropathic pain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Creative Scientific Research, Japan Society for the Promotion of Science, 2006 - 2010

INOUE Kazuhide, TSUDA Makoto, SAITOH Hidetoshi, NAKATSUKA Terumasa
細胞外ATPを介したアストログリア-ニューロン相互調節機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2007

井上和秀, 津田誠, 小泉修一
ミクログリアを介する神経因性疼痛発症メカニズムの総合理解

科学研究費助成事業, 基盤研究(S), 日本学術振興会, 2006 - 2006

井上和秀
The role of neuron-glia interaction in neuropathic pain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2003 - 2005

INOUE Kazuhide, KOIZUMI Schuichi, TSUDA Makoto
Neuronal and behavioral research on the function of ATP receptors in the signal trasnduction of pain.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1999 - 2002

INOUE Kazuhide, KOIZUMI Schuichi
A neuropharmacological Research for the Function of ATP Receptors in the Nociception

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1996 - 1998

INOUE Kazuhide, UENO Shinya, KOIZUMI Schuichi
ATP受容体の生理機能と分子機構に関する総合的基礎研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1997 - 1997

山下勝幸, 多久和陽, 井上和秀, 古家喜四夫, 桂木猛, 森際克子
Chromaffin cells as a neuron model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1995 - 1996

KANNO Tomio, TERAKAWA Susumu, KUMAKURA Konosuke, WARASHINA Akira, YANAGIHARA Nobuyuki, NAKAZATO Yoshikazu
Regulation of Exocytosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1994 - 1995

KUMAKURA Konosuke, TATHAM Peter, GOMPERTS Bastian D., HIDE Izumi, IMAIZUMI Mica, INOUE Kazuhide, TERAKAWA Susumu, DUCHEN Michael R.
クローン神経細胞を用いたレセプターアッセイによる抗うつ剤作用機序の検討

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1984 - 1984

井上和秀
ラット胎仔中枢神経系の発達に及ぼすエチルアルコール母体投与の影響

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1983 - 1983

井上和秀
グリア-ニューロン相互作用におけるATP受容体の生理機能、薬理作用の解明。