西川秋佳 (Akiyoshi Nishikawa) - マイポータル

基本情報

所属: 厚生労働省国立医薬品食品衛生研究所安全性生物試験研究センターセンター長

学位: 医学博士(岐阜大学)

J-GLOBAL ID: 200901055611689435
researchmap会員ID: 0000041191

研究キーワード

研究分野

ライフサイエンス / 実験病理学 /

委員歴

International Academy of Cytology, FIAC

論文

156

Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water

Young-Man Cho, Mai Hasumura, Toshio Imai, Shigeaki Takami, Akiyoshi Nishikawa, Kumiko Ogawa

JOURNAL OF APPLIED TOXICOLOGY 37(7) 853-862 2017年7月査読有り
Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination

Tadashi Hirata, Young-Man Cho, Takeshi Toyoda, Jun-ichi Akagi, Isamu Suzuki, Akiyoshi Nishikawa, Kumiko Ogawa

JOURNAL OF APPLIED TOXICOLOGY 37(6) 683-691 2017年6月査読有り
Non-neoplastic lesions found only in the two-year bioassays but not in shorter toxicity studies of rats

Mizuho Nonaka, Iouhei Amakasu, Yukie Saegusa, Misaki Naota, Takuya Nishimura, Kumiko Ogawa, Akiyoshi Nishikawa

REGULATORY TOXICOLOGY AND PHARMACOLOGY 86 199-204 2017年6月査読有り
Toxic effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity

Isamu Suzuki, Young-Man Cho, Tadashi Hirata, Takeshi Toyoda, Jun-ichi Akagi, Yasushi Nakamura, Azusa Sasaki, Takako Nakamura, Shigehisa Okamoto, Koji Shirota, Noboru Suetome, Akiyoshi Nishikawa, Kumiko Ogawa

JOURNAL OF APPLIED TOXICOLOGY 37(4) 485-494 2017年4月査読有り
Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis in gpt delta rats

Daisuke Hibi, Yu Yokoo, Yuta Suzuki, Yuji Ishii, Meilan Jin, Aki Kijima, Takehiko Nohmi, Akiyoshi Nishikawa, Takashi Umemura

JOURNAL OF APPLIED TOXICOLOGY 37(2) 142-149 2017年2月査読有り
Altered susceptibility of an obese rat model to 13-week subchronic toxicity induced by 3-monochloropropane-1,2-diol

Takeshi Toyoda, Young-Man Cho, Jun-ichi Akagi, Yasuko Mizuta, Kohei Matsushita, Akiyoshi Nishikawa, Katsumi Imaida, Kumiko Ogawa

JOURNAL OF TOXICOLOGICAL SCIENCES 42(1) 1-11 2017年2月査読有り
Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines

Masashi Sekimoto, Haruna Sumi, Takuomi Hosaka, Takashi Umemura, Akiyoshi Nishikawa, Masakuni Degawa

FOOD AND CHEMICAL TOXICOLOGY 97 256-264 2016年11月査読有り
Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils

Takeshi Toyoda, Liang Shi, Shinji Takasu, Young-Man Cho, Yuka Kiriyama, Akiyoshi Nishikawa, Kumiko Ogawa, Masae Tatematsu, Tetsuya Tsukamoto

HELICOBACTER 21(2) 131-142 2016年4月査読有り
International Harmonization and Cooperation in the Validation of Alternative Methods

Joao Barroso, Il Young Ahn, Cristiane Caldeira, Paul L. Carmichael, Warren Casey, Sandra Coecke, Rodger Curren, Bertrand Desprez, Chantra Eskes, Claudius Griesinger, Jiabin Guo, Erin Hill, Annett Janusch Roi, Hajime Kojima, Jin Li, Chae Hyung Lim, Wlamir Moura, Akiyoshi Nishikawa, HyeKyung Park, Shuangqing Peng, Octavio Presgrave, Tim Singer, Soo Jung Sohn, Carl Westmoreland, Maurice Whelan, Xingfen Yang, Ying Yang, Valerie Zuang

VALIDATION OF ALTERNATIVE METHODS FOR TOXICITY TESTING 856 343-386 2016年査読有り
4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats

Isamu Suzuki, Young-Man Cho, Tadashi Hirata, Takeshi Toyoda, Jun-ichi Akagi, Yasushi Nakamura, Eun Young Park, Azusa Sasaki, Takako Nakamura, Shigehisa Okamoto, Koji Shirota, Noboru Suetome, Akiyoshi Nishikawa, Kumiko Ogawa

JOURNAL OF TOXICOLOGIC PATHOLOGY 29(4) 237-246 2016年査読有り
Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX.

Toyoda T, Cho YM, Akagi J, Mizuta Y, Hirata T, Nishikawa A, Ogawa K

Toxicological sciences : an official journal of the Society of Toxicology 148(2) 400-408 2015年12月査読有り
Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat

Saeko Onami, Young-Man Cho, Takeshi Toyoda, Jun-ichi Akagi, Satoshi Fujiwara, Ryosuke Ochiai, Kazushige Tsujino, Akiyoshi Nishikawa, Kumiko Ogawa

REGULATORY TOXICOLOGY AND PHARMACOLOGY 73(3) 726-731 2015年12月査読有り
Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats

Jun-ichi Akagi, Takeshi Toyoda, Young-Man Cho, Yasuko Mizuta, Takehiko Nohmi, Akiyoshi Nishikawa, Kumiko Ogawa

CANCER SCIENCE 106(5) 529-541 2015年5月査読有り
Acrylamide induces specific DNA adduct formation and gene mutations in a carcinogenic target site, the mouse lung

Yuji Ishii, Kohei Matsushita, Ken Kuroda, Yuh Yokoo, Aki Kijima, Shinji Takasu, Yukio Kodama, Akiyoshi Nishikawa, Takashi Umemura

MUTAGENESIS 30(2) 227-235 2015年3月査読有り
A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action

Kohei Matsushita, Yuji Ishii, Shinji Takasu, Ken Kuroda, Aki Kijima, Takuma Tsuchiya, Hiroaki Kawaguchi, Noriaki Miyoshi, Takehiko Nohmi, Kumiko Ogawa, Akiyoshi Nishikawa, Takashi Umemura

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 67(1) 31-39 2015年1月査読有り
Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents

Kenichi Masumura, Yasuteru Sakamoto, Wakako Kumita, Masamitsu Honma, Akiyoshi Nishikawa, Takehiko Nohmi

Genes and Environment 37(1) 24 2015年査読有り
Inhibitory Potential of Postnatal Treatment with Cyclopamine, a Hedgehog Signaling Inhibitor, on Medulloblastoma Development in Ptch1 Heterozygous Mice

Saori Matsuo, Miwa Takahashi, Kaoru Inoue, Kei Tamura, Kaoru Irie, Yukio Kodama, Akiyoshi Nishikawa, Midori Yoshida

TOXICOLOGIC PATHOLOGY 42(8) 1174-1187 2014年12月査読有り
Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats

Miwa Takahashi, Midori Yoshida, Kaoru Inoue, Tomomi Morikawa, Akiyoshi Nishikawa, Kumiko Ogawa

FOOD AND CHEMICAL TOXICOLOGY 73 84-94 2014年11月査読有り
Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action

Kohei Matsushita, Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Hiroaki Kawaguchi, Noriaki Miyoshi, Takehiko Nohmi, Kurniko Ogawa, Akiyoshi Nishikawa, Takashi Umemura

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 66(7) 313-321 2014年9月査読有り
Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats

Saeko Onami, Young-man Cho, Takeshi Toyoda, Katsuyoshi Horibata, Yuji Ishii, Takashi Umemura, Masamitsu Honma, Takehiko Nohmi, Akiyoshi Nishikawa, Kumiko Ogawa

MUTAGENESIS 29(4) 295-302 2014年7月査読有り

もっとみる

MISC

163

Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer

IS Lee, A Nishikawa

LIFE SCIENCES 73(25) 3225-3234 2003年11月
Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer

IS Lee, A Nishikawa

LIFE SCIENCES 73(25) 3225-3234 2003年11月
Okazaki, K., Umemura, T., Imazawa, T., Nishikawa, A., Masegi, T., Hirose, M.: Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.

OKAZAKI K, UMEMURA T, IMAZAWA T, NISHIKAWA A, MASEGI T, HIROSE M

Cancer Sci. 94(11) 948-952 2003年
Imazawa, T., Nishikawa, A., Toyoda, K., Furukawa, F., Mitsui. M., Hirose, M.: Sequential alteration of apoptosis, p53 expression and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.

Toxicol. Pathol. 31 625-631 2003年
Masumura, K., Horiguchi, M., Nishikawa, A., Umemura, T., Kanki, K., Kanke, Y., Nohmi, T.: Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.

Mutat. Res. 541 91-102 2003年
Kitamura, Y., Yamagishi, M., Okazaki, K., Son, H-Y., Imazawa, T., Nishikawa, A., Iwata, T., Yamauchi, Y., Kasai, M., Tsutsumi, K., Hirose, M.: Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5・・・

Cancer Lett. 200(. 133-139) 2003年
Son, H-Y., Nishikawa, A., Okazaki, K., Lee, K-Y., Imazawa, T., Hirose, M.: Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).

Food Chem. Toxicol. 41 1811-1816 2003年
Kitamura, Y., Nishikawa, A., Furukawa, F., Nakamura, H., Okazaki, K., Umemura, T., Imazawa, T., Hirose, M.: A subchronic toxicity study of shea nut color in Wistar rats.

Food Chem. Toxicol. 41 1537-1542 2003年
Kanki, K., Nishikawa, A., Furukawa, F., Kitamura, Y., Imazawa, T., Umemura, T., Hirose, M.: A 13-week subchronic toxicity study of paprika color in F344 rats.

Food Chem. Toxic. 41 1337-1343 2003年
Umemura, T., Kai, S., Hasegawa, R., Kanki, K., Kitamura, Y., Nishikawa, A., Hirose, M.: Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by ・・・

Carcinogenesis 24 1105-1109 2003年
Son, H-Y., Nishikawa, A., Kanki, K., Okazaki, K., Kitamura, Y., Lee, K-Y., Umemura, T., Hirose, M.: Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-h・・・

SON H‐Y, NISHIKAWA A, KANKI K, OKAZAKI K, KITAMURA Y, LEE K‐Y, UMEMURA T, HIROSE M

Cancer Science 94(4) 334-337 2003年
Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology.

J. Toxicol. Pathol. 16(1) 1-17 2003年
Yamagishi, M., Natsume, M., Osakabe, N., Okazaki, K., Furukawa, F., Imazawa, T., Nishikawa, A., Hirose, M.: Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.

Cancer Lett. 191 49-57 2003年
Umemura, T., Kodama, Y., Kanki, K., Iatropoulos, M., Nishikawa, A., Hirose, M., Williams, G.M.: Pentachlorophenol (but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitrosamine to cholangio cystic neoplasms in B6C3F1 mice pos・・・

Toxicol. Pathol. 31 10-13 2003年
Furukawa, F., Nishikawa, A., Lee, I-S., Kanki, K., Umemura, T., Okazaki, K., Kawamori, T., Wakabayashi, K., Hirose, M.: A COX-2 inhibitor, nimesulide, inhibits post-initiation phase of N-nitrosobis(2-oxopropyl)amine- induced pancreatic carcinoge・・・

Int. J. Cancer 104 269-273 2003年
Son, H-Y., Nishikawa, A., Okazaki, K., Kanki, K., Yamagishi, M., Imazawa, T., Umemura, T., Hirose, M.: Prolonged effects of β-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.

Cancer Lett. 190 21-29 2003年
Okazaki, K., Umemura, T., Imazawa, T., Nishikawa, A., Masegi, T., Hirose, M.: Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.

Cancer Sci. 94(11) 948-952 2003年
Imazawa, T., Nishikawa, A., Toyoda, K., Furukawa, F., Mitsui. M., Hirose, M.: Sequential alteration of apoptosis, p53 expression and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.

Toxicol. Pathol. 31 625-631 2003年
Masumura, K., Horiguchi, M., Nishikawa, A., Umemura, T., Kanki, K., Kanke, Y., Nohmi, T.: Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.

Mutat. Res. 541 91-102 2003年
Kitamura, Y., Yamagishi, M., Okazaki, K., Son, H-Y., Imazawa, T., Nishikawa, A., Iwata, T., Yamauchi, Y., Kasai, M., Tsutsumi, K., Hirose, M.: Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5・・・

Cancer Lett. 200 133-139 2003年

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所属学協会

共同研究・競争的資金等の研究課題

発がんの分子機構に関する研究

2001年 - 2005年
molecular mechanisms underlying chemical carcinogenesis