小野敦 (Atsushi Ono) - マイポータル

基本情報

所属: 岡山大学医歯薬学総合研究科・薬学系教授
: 厚生労働省国立医薬品食品衛生研究所客員研究員

学位: 薬学博士(2000年7月昭和大学)

J-GLOBAL ID: 200901008856913120
researchmap会員ID: 0000041198

研究キーワード

研究分野

ライフサイエンス / 薬系衛生、生物化学 / 毒性学

経歴

2016年8月 - 現在

岡山大学, 教授
1993年 - 2016年

厚生労働省国立医薬品食品衛生研究所

学歴

1990年 - 1992年

北海道大学, 薬学研究科
1987年 - 1990年

北海道大学, 薬学部

委員歴

2021年1月 - 現在

厚生労働省, 薬事・食品衛生審議会専門委員
2020年4月 - 現在

内閣府, 食品安全委員会専門委員
2020年3月 - 現在

OECD, Advisory Group on Endocrine Disrupters Testing and Assessment
2020年2月 - 現在

厚生労働省, 労働安全衛生法GLP専門家
2019年4月 - 現在

OECD, Residue Definition Working Group
2019年4月 - 現在

医薬品医療機器総合機構, 専門委員
2015年4月 - 現在

OECD, QSAR Toolbox Management Group

受賞

論文

Borderline Range Determined Using Data From Validation Study of Alternative Methods for Skin Sensitization: ADRA, IL-8 Luc Assay, and EpiSensA.

Toshihiko Kasahara, Yusuke Yamamoto, Natsumi Nakashima, Mika Imamura, Hideyuki Mizumachi, Sho Suzuki, Setsuya Aiba, Yutaka Kimura, Takao Ashikaga, Hajime Kojima …

Journal of applied toxicology : JAT 45(3) 432-439 2025年3月査読有り
Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach.

Masaharu Fujita, Natsumi Nakashima, Sayaka Wanibuchi, Yusuke Yamamoto, Hajime Kojima, Atsushi Ono, Toshihiko Kasahara

Journal of applied toxicology : JAT 43(3) 446-457 2023年3月査読有り
Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha.

Susumu Kodama, Shuzo Matsumoto, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Atsushi Ono, Hiroki Kakuta

Toxicology letters 373 76-83 2023年1月15日査読有り
Applicability of amino acid derivative reactivity assay (4 mM) for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events

Mika Imamura, Yusuke Yamamoto, Masaharu Fujita, Sayaka Wanibuchi, Natsumi Nakashima, Hajime Kojima, Atsushi Ono, Toshihiko Kasahara

Journal of Applied Toxicology 42(7) 1159-1167 2022年7月査読有り
Within‐ and between‐laboratory reproducibility and predictive capacity of amino acid derivative reactivity assay (ADRA) using a 0.5 mg/mL test chemical solution: Results of the study for reproducibility confirmation implemented in five participating laboratories

Yusuke Yamamoto, Masaharu Fujita, Shinichi Watanabe, Hiroaki Yamaga, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kazuya Takeuchi, Kohei Kamiya …

Journal of Applied Toxicology 42(6) 1078-1090 2022年6月査読有り
Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells <i>via</i> S1PR3 by Ligand-Independent Notch Activation

Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Yasunari Kanda

Biological and Pharmaceutical Bulletin 45(5) 649-658 2022年5月1日査読有り
Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.

Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda

International journal of molecular sciences 23(4) 1967-1967 2022年2月10日査読有り
The within‐ and between‐laboratories reproducibility and predictive capacity of Amino acid Derivative Reactivity Assay using 4 mM test chemical solution: Results of ring study implemented at five participating laboratories

Masaharu Fujita, Yusuke Yamamoto, Sayaka Wanibuchi, Shinichi Watanabe, Hiroaki Yamaga, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kazuya Takeuchi …

Journal of Applied Toxicology 42(2) 318-333 2022年2月査読有り
Proarrhythmia Risk Assessment Using Electro-Mechanical Window in Human iPS Cell-Derived Cardiomyocytes.

Shota Yanagida, Ayano Satsuka, Sayo Hayashi, Atsushi Ono, Yasunari Kanda

Biological & pharmaceutical bulletin 45(7) 940-947 2022年査読有り
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance.

Ayano Satsuka, Sayo Hayashi, Shota Yanagida, Atsushi Ono, Yasunari Kanda

Journal of pharmacological and toxicological methods 118 107227-107227 2022年査読有り
Comprehensive Cardiotoxicity Assessment of COVID-19 Treatments Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Shota Yanagida, Ayano Satsuka, Sayo Hayashi, Atsushi Ono, Yasunari Kanda

Toxicological sciences : an official journal of the Society of Toxicology 183(1) 227-239 2021年8月30日査読有り
Refinement of decision tree to assess the consequences of increased serum ALP in dogs: Additional analysis on toxicity studies of pesticides evaluated recently in Japan

Yoko Yokoyama, Atsushi Ono, Midori Yoshida, Kiyoshi Matsumoto, Mikako Saito

Regulatory Toxicology and Pharmacology 124 104963-104963 2021年8月査読有り
FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation.

Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yasunari Kanda

International journal of molecular sciences 22(14) 2021年7月6日査読有り
Characterisation and validation of an in vitro transactivation assay based on the 22Rv1/MMTV_GR-KO cell line to detect human androgen receptor agonists and antagonists

Yooheon Park, Da-Woon Jung, Anne Milcamps, Masahiro Takeyoshi, Miriam N. Jacobs, Keith A. Houck, Atsushi Ono, Toine F.H. Bovee, Patience Browne, Nathalie Delrue …

Food and Chemical Toxicology 152 112206-112206 2021年6月査読有り
Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution

Mika Imamura, Sayaka Wanibuchi, Yusuke Yamamoto, Hajime Kojima, Atsushi Ono, Toshihiko Kasahara, Masaharu Fujita

Journal of Applied Toxicology 41(2) 303-329 2021年2月査読有り
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats

Susumu Kodama, Nao Yoshii, Akihiro Ota, Jun-ichi Takeshita, Kouichi Yoshinari, Atsushi Ono

The Journal of Toxicological Sciences 46(12) 569-587 2021年査読有り
Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes

Shota Yanagida, Ayano Satsuka, Sayo Hayashi, Atsushi Ono, Yasunari Kanda

The Journal of Toxicological Sciences 46(8) 359-369 2021年査読有り
Oxidation of a cysteine‐derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

Miyuki Akimoto, Yusuke Yamamoto, Shinichi Watanabe, Hiroaki Yamaga, Kousuke Yoshida, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kei Kusakari …

Journal of Applied Toxicology 40(6) 843-854 2020年6月査読有り
Toxicological significance of increased serum alkaline phosphatase activity in dog studies of pesticides: Analysis of toxicological data evaluated in Japan

Yoko Yokoyama, Atsushi Ono, Midori Yoshida, Kiyoshi Matsumoto, Mikako Saito

Regulatory Toxicology and Pharmacology 109 104482-104482 2019年12月査読有り
The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories.

Masaharu Fujita, Yusuke Yamamoto, Shinichi Watanabe, Tsunetsugu Sugawara, Koji Wakabayashi, Yu Tahara, Nobuyuki Horie, Keiichi Fujimoto, Kei Kusakari, Yoshihiko Kurokawa …

Journal of applied toxicology : JAT 39(11) 1492-1505 2019年11月査読有り

もっとみる

MISC

Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats

Igarashi, T., Takashima, H., Takabe, M., Suzuki, H., Ushida, K., Kawamura, T., Matsumoto, M., Iso, T., Tanabe, S., Inoue, K. …

Regulatory Toxicology and Pharmacology 100 105-117 2018年12月1日
サリチル酸ベンジルの遺伝毒性、反復投与毒性及び生殖発生毒性のスクリーニング

五十嵐智女, 髙部道仁, 髙島宏昌, 鈴木洋, 牛田和夫, 松本真理子, 磯貴子, 川村智子, 井上薫, 小野敦 …

Journal of Toxicological Sciences 43(Supplement) P-110 2018年
Japan Flavour and Fragrance Materials Association’s (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additiona

Kenji Saito, Yasuko Hasegawa-Baba, Fumiko Sekiya, Shim mo Hayashi, Yoshiharu Mirokuji, Hiroyuki Okamura, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima, Masakuni Degawa …

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 34(9) 1474-1484 2017年
Risk assessment of skin lightening cosmetics containing hydroquinone

Mariko Matsumoto, Hiroaki Todo, Takumi Akiyama, Mutsuko Hirata-Koizumi, Kenji Sugibayashi, Yoshiaki Ikarashi, Atsushi Ono, Akihiko Hirose, Kazuhito Yokoyama

REGULATORY TOXICOLOGY AND PHARMACOLOGY 81 128-135 2016年11月
Evaluation of the OECD QSAR toolbox in the screening of chemical sensitizer

A. Ono, H. Jinno, A. Hirose

TOXICOLOGY LETTERS 259 S228-S228 2016年10月
Transcriptome analyses demonstrate that peroxisome proliferator-activated receptor α (PPARα) activity of an ultraviolet absorber, 2-(2’-hydroxy-3’,5’-di-tert-butylphenyl) benzotriazole, as possible mechanism of their toxicity and the gender differences

Mutsuko Hirata-Koizumi, Ryota Ise, Hirohito Kato, Takashi Matsuyama, Tomoko Nishimaki-Mogami, Mika Takahashi, Atsushi Ono, Makoto Ema, Akihiko Hirose

Journal of Toxicological Sciences 41(5) 693-700 2016年10月1日
Comparative analysis of respiratory and skin sensitization potential of chemicals using Japanese GHS classification

A. Ono, H. Jinno, A. Hirose

TOXICOLOGY LETTERS 258 S137-S137 2016年9月
Summary information of human health hazard assessment of existing chemical substances (II)

Mika Takahashi, Mariko Matsumoto, Takashi Yamada, Atsushi Ono, Akihiko Hirose

Bulletin of National Institute of Health Sciences 2016(134) 79-83 2016年1月1日
Repeated Dose and Reproductive/Developmental Toxicity of Perfluorododecanoic Acid in Rats

Hina Kato, Sakiko Fujii, Mika Takahashi, Mariko Matsumoto, Mutsuko Hirata-Koizumi, Atsushi Ono, Akihiko Hirose

ENVIRONMENTAL TOXICOLOGY 30(11) 1244-1263 2015年11月
Is a 14-day dose setting study able to predict its 28-day repeated dose toxicity?

A. Ono, M. Matsumoto, M. Takahashi, T. Kawamura, M. Hirata-Koizumi, A. Hirose

TOXICOLOGY LETTERS 238(2) S340-S340 2015年10月
Authors' response to Letter to the Editor by Jeff Kelsey et al. "Response to 'Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether.'" 2015

Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose, Makoto Hayashi

REGULATORY TOXICOLOGY AND PHARMACOLOGY 73(1) 209-209 2015年10月
The Japan Flavour and Fragrance Materials Association’s (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan

Hiroyuki Okamura, Hajime Abe, Yasuko Hasegawa-Baba, Kenji Saito, Fumiko Sekiya, Shim Mo Hayashi, Yoshiharu Mirokuji, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima …

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 32(9) 1384-1396 2015年9月
Summary information of human health hazard assessment of existing chemical substances(I)

Mariko Matsumoto, Katsumi Kobayashi, Mika Takahashi, Mutsuko Hirata-Koizumi, Atsushi Ono, Akihiko Hirose

Bulletin of National Institute of Health Sciences 2015(133) 42-47 2015年
Open TG-GATEs: a large-scale toxicogenomics database

Yoshinobu Igarashi, Noriyuki Nakatsu, Tomoya Yamashita, Atsushi Ono, Yasuo Ohno, Tetsuro Urushidani, Hiroshi Yamada

NUCLEIC ACIDS RESEARCH 43(D1) D921-D927 2015年1月
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model

Ko Omura, Takeki Uehara, Yuji Morikawa, Hitomi Hayashi, Kunitoshi Mitsumori, Keiichi Minami, Masayuki Kanki, Hiroshi Yamada, Atsushi Ono, Tetsuro Urushidani

Journal of Toxicological Sciences 39(6) 837-848 2014年12月1日
Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether

Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose, Makoto Hayashi

REGULATORY TOXICOLOGY AND PHARMACOLOGY 70(3) 711-719 2014年12月
Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice

Mariko Matsumoto, Mariko Matsumoto, Shoji Masumori, Mutsuko Hirata-Koizumi, Atsushi Ono, Masamitsu Honma, Kazuhito Yokoyama, Akihiko Hirose

Mutation Research - Genetic Toxicology and Environmental Mutagenesis 775 94-98 2014年12月
Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats

Takeki Uehara, Akira Horinouchi, Yuji Morikawa, Yutaka Tonomura, Keiichi Minami, Atsushi Ono, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

JOURNAL OF APPLIED TOXICOLOGY 34(10) 1087-1095 2014年10月
Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats

Hiroyuki Hanafusa, Yuji Morikawa, Takeki Uehara, Masako Kaneto, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

TOXICOLOGY 324 43-54 2014年10月
Combined repeated dose toxicity studies with the reproduction/developmental toxicity screening tests for long-chain perfluoroalkyl carboxylic acids in rats

Akihiko Hirose, Sakiko Fujii, Toshinari Suzuki, Hina Kato, Tomoko Kawamura, Mika Takahashi, Mariko Matsumoto, Mutsuko Hirata-Koizumi, Atsushi Ono, Tomoko Nishimaki-Mogam …

TOXICOLOGY LETTERS 229 S235-S235 2014年9月

もっとみる

書籍等出版物

衛生薬学 : 健康と環境

原, 俊太郎, 姫野, 誠一郎, 吉成, 浩一 (担当:分担執筆, 範囲:8.4 化学物質の安全性評価と規制)

丸善出版 2025年2月 (ISBN: 9784621310519)
化学物質の複合影響と健康リスク評価

青木, 康展, 青山, 博昭 (担当:分担執筆, 範囲:第４章．毒性学的懸念の閾値（TTC，Threshold of Toxicological Concern）)

医歯薬出版 2024年2月 (ISBN: 9784263732205)

担当経験のある科目(授業)

衛生薬学 (岡山大学)

所属学協会

共同研究・競争的資金等の研究課題

内分泌かく乱in vitroスクリーニング

厚生労働科学研究費補助金
構造活性相関

厚生労働科学研究費補助金
トキシコゲノミクス

厚生労働科学研究費補助金
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小野敦

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

論文

MISC

書籍等出版物

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧