Takashi Umemura

Profile Information

Affiliation: Yamazaki University of Animal Health Technology
: 客員研究員, 厚生労働省国立医薬品食品衛生研究所

J-GLOBAL ID: 200901044625433954
researchmap Member ID: 0000041246

Research Interests

Research Areas

Life sciences / Veterinary medicine /

Research History

Apr, 2017 - Present

Professor, Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology

Papers

162

Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment.

Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita, Ken-Ichi Masumura, Takehiko Nohmi, Takashi Umemura

Mutation research. Genetic toxicology and environmental mutagenesis, 894 503729-503729, 2024
Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats

Tatsuya Mitsumoto, Yuji Ishii, Norifumi Takimoto, Shinji Takasu, Moeka Namiki, Takehiko Nohmi, Takashi Umemura, Kumiko Ogawa

Arch. Toxicol., Oct, 2023 Peer-reviewed
A 13-week comprehensive toxicity study with adductome analysis demonstrates the toxicity, genotoxicity, and carcinogenicity of the natural flavoring agent elemicin

Yuji Ishii, Liang Shi, Shinji Takasu, Kumiko Ogawa, Takashi Umemura

Food and Chemical Toxicology, 179 113965-113965, Sep, 2023
Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.

Ken Kuroda, Yuji Ishii, Shinji Takasu, Kohei Matsushita, Aki Kijima, Takehiko Nohmi, Takashi Umemura

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 168 113365-113365, Aug 12, 2022
The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.

Yuji Ishii, Shinji Takasu, Petr Grúz, Kenichi Masumura, Kumiko Ogawa, Takehiko Nohmi, Takashi Umemura

Mutagenesis, 36(2) 155-164, May 31, 2021
Application of the benchmark dose method to the incidence data for various pathological findings and its validation analysis,さまざまな病理所見へのベンチマークドーズ法の適用とその妥当性検討

Inoue, K., Shigeta, Y., Umemura, T., Nishiura, H., Hirose, A.

Journal of the Food Hygienic Society of Japan, 62(2), 2021
急性肝再生過程におけるON/OFF制御へのNrf2の関与

高須伸二, 松本佳奈, 石井雄二, 小川久美子, 梅村隆志

日本毒性病理学会講演要旨集, 37回 64-64, Jan, 2021
Background data of 2-year-old male and female F344 gpt delta rats.

Kohei Matsushita, Yuji Ishii, Aki Kijima, Shinji Takasu, Ken Kuroda, Hisayoshi Takagi, Takehiko Nohmi, Kumiko Ogawa, Takashi Umemura

Journal of toxicologic pathology, 34(1) 23-31, Jan, 2021
Furan Induced Characteristic Glutathione S-Transferase Placental Form-Positive Foci in Terms of Cell Kinetics and Gene Expression.

Shinji Takasu, Yuji Ishii, Aki Kijima, Kumiko Ogawa, Sae Nakane, Takashi Umemura

Toxicologic pathology, 48(6) 756-765, Aug, 2020
レポーター遺伝子導入動物を用いたin vivo変異原性試験と網羅的DNA付加体解析を用いたエレミシンの発がん性評価

石井雄二, 高須伸二, 中村賢志, 木島綾希, 小川久美子, 梅村隆志

日本薬学会年会要旨集, 140年会 27X-am06, Mar, 2020
DNA modifications that do not cause gene mutations confer the potential for mutagenicity by combined treatment with food chemicals.

Yuji Ishii, Yuh Yokoo, Aki Kijima, Shinji Takasu, Kumiko Ogawa, Takashi Umemura

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 129 144-152, Jul, 2019 Peer-reviewed
Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin-3-O-primeveroside.

Yuji Ishii, Aki Kijima, Shinji Takasu, Kumiko Ogawa, Takashi Umemura

Journal of applied toxicology : JAT, 39(4) 650-657, Apr, 2019 Peer-reviewed
Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice.

Shinji Takasu, Yuh Yokoo, Yuji Ishii, Aki Kijima, Kumiko Ogawa, Takashi Umemura

Toxicologic pathology, 47(1) 44-52, Jan, 2019 Peer-reviewed
Mechanisms Underlying Exacerbation of Osmotic Nephrosis Caused by Pre-existing Kidney Injury.

Kohei Matsushita, Shinji Takasu, Ken Kuroda, Yuji Ishii, Aki Kijima, Kumiko Ogawa, Takashi Umemura

Toxicological sciences : an official journal of the Society of Toxicology, 165(2) 420-430, Oct 1, 2018 Peer-reviewed
Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice.

Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T

Journal of toxicologic pathology, 31(3) 169-178, Jul, 2018 Peer-reviewed
Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin.

Tsuchiya T, Kijima A, Ishii Y, Takasu S, Yokoo Y, Nishikawa A, Yanai T, Umemura T

Journal of toxicologic pathology, 31(3) 179-188, Jul, 2018 Peer-reviewed
Guidelines for Safety Assessments of Nutrient-related Food Additives

高須伸二, 梅村隆志, 梅村隆志

日本栄養・食糧学会誌, 71(3) 117‐120(J‐STAGE), 2018
Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis

Yuji Ishii, Ken Kuroda, Kohei Matsushita, Yuh Yokoo, Shinji Takasu, Aki Kijima, Takehiko Nohmi, Kumiko Ogawa, Takashi Umemura

TOXICOLOGY AND APPLIED PHARMACOLOGY, 336 75-83, Dec, 2017 Peer-reviewed
In vivo reporter gene mutation and micronucleus assays in gpt delta mice treated with a flame retardant decabromodiphenyl ether

Shinji Takasu, Yuji Ishii, Yuh Yokoo, Takuma Tsuchiya, Aid Kijima, Yukio Kodama, Kumiko Ogawa, Takashi Umemura

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 816 7-11, Apr, 2017 Peer-reviewed
Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis in gpt delta rats

Daisuke Hibi, Yu Yokoo, Yuta Suzuki, Yuji Ishii, Meilan Jin, Aki Kijima, Takehiko Nohmi, Akiyoshi Nishikawa, Takashi Umemura

JOURNAL OF APPLIED TOXICOLOGY, 37(2) 142-149, Feb, 2017 Peer-reviewed

Misc.

182

The Role of Genotoxicity in the Carcinogenicity of Acrylamide in the Lungs and Harderian Glands of Mice

Yuji Ishii, Shinji Takasu, Kenji Nakamura, Aki Kijima, Kumiko Ogawa, Takashi Umemura

SOT2020, Mar, 2020
Examination of carcinogenicity of elemicin using reporter gene mutation assay and comprehensive DNA adduct analysis

石井雄二, 高須伸二, 中村賢志, 木島綾希, 小川久美子, 梅村隆志, 梅村隆志

日本薬学会年会要旨集(CD-ROM), 140th (Web), 2020
異なる細胞動態を示すFuran及びDEN誘発GST-P陽性細胞巣におけるSox9の発現

高須伸二, 中根冴, 中根冴, 石井雄二, 木島綾希, 小川久美子, 梅村隆志, 梅村隆志

日本毒性病理学会講演要旨集, 36th, 2020
gpt deltaラットを用いたin vivo変異原性試験と網羅的DNA損傷解析によるエレミシンの遺伝毒性および発がん性の検索

石井雄二, 高須伸二, 中村賢志, 小川久美子, 梅村隆志, 梅村隆志

日本食品化学学会総会・学術大会講演要旨集, 26th, 2020
The relationship between acrylamide-induced DNA adducts and, mutagenicity and carcinogenesity

石井雄二, 高須伸二, 中村賢志, 木島綾希, 小川久美子, 梅村隆志, 梅村隆志

Journal of Toxicological Sciences, 45(Supplement), 2020
A 28-day repeated oral dose toxicity study of 5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)methyl methyl methylphosphonate in mice

Sep, 2019
Comprehensive DNA analysis for DNA modifications and reporter gene mutation assay to investigate genotoxicity of elemicin and its mechanisms using gpt delta rats

Jul, 2019
発がん条件下におけるアクリルアミドの突然変異誘発性の検索

Yuji Ishii, Shinji Takasu, Kenji Nakamura, Aki Kijima, Kumiko Ogawa, Takashi Umemura

Journal of Toxicological Sciences, Jun, 2019
F344ラットを用いたアセタミドの28日間反復投与による肝毒性評価

石井雄二, 菊池玲美花, 木島綾希, 高須伸二, 小川久美子, 梅村隆志

第35回日本毒性病理学会, 35th 72(JA),170(EN), Jan, 2019
F344ラットを用いた5‐methyl‐2‐phenyl‐2‐hexenalの90日間反復投与毒性試験

中村賢志, 木嶋綾希, 石井雄二, 高須伸二, 小川久美子, 梅村隆志

第35回日本毒性病理学会, 2019
ラット肝臓におけるGST‐P陽性巣の種々発がん物質休薬後動態の検討

高須伸二, 中村くるみ, 石黒結唯, 石井雄二, 木島綾希, 小川久美子, 梅村隆志

日本毒性病理学会講演要旨集, 35th, Jan, 2019
gpt deltaラットを用いたin vivo変異原性試験と網羅的DNA損傷解析によるエレミシンの肝発がん機序の解明

石井雄二, SHI Liang, 高須伸二, 木島綾希, 能美健彦, 小川久美子, 梅村隆志, 梅村隆志

日本環境変異原学会大会プログラム・要旨集, 47th 99, Oct 10, 2018
食品香料である5‐methylfurfuralのF344ラットにおける90日間反復投与毒性試験

木島綾希, 石井雄二, 高須伸二, 梅村隆志, 梅村隆志, 小川久美子

日本食品化学学会総会・学術大会講演要旨集, 24th 122, May 17, 2018
F344ラットにおける2‐Furanmethanethiolの13週間反復経口投与による毒性評価

SHI Liang, SHI‐Liang, 石井雄二, 高須伸二, 土屋卓磨, 木島綾希, 小川久美子, 西川秋佳, 梅村隆志

日本毒性病理学会講演要旨集, 34th 90(JA),204(EN), 2018
異なる挙動を示すFuran及びDEN誘発GST‐P陽性細胞巣の網羅的遺伝子発現解析

高須伸二, 石井雄二, 木島綾希, 小川久美子, 梅村隆志, 梅村隆志

日本毒性病理学会講演要旨集, 34th 114(JA),228(EN), 2018
F344系gpt deltaラットの自然発生病変スペクトラム

松下幸平, 木島綾希, 石井雄二, 高須伸二, 黒田顕, 能美健彦, 小川久美子, 梅村隆志, 梅村隆志

日本毒性病理学会講演要旨集, 34回 97-97, Jan, 2018
肝発がん物質EstragoleのDNA修飾に対するDNA Polymerase ζの作用

石井雄二, 高須伸二, 木島綾希, 能美健彦, 小川久美子, 梅村隆志, 梅村隆志

日本環境変異原学会大会プログラム・要旨集, 46th 100, Oct, 2017
急性的な増殖刺激により惹起される肝細胞再生過程におけるNrf2の関与

高須伸二, 石井雄二, 木島綾希, 小川久美子, 梅村隆志

Journal of Toxicological Sciences, 42(Supplement) S289, Jun, 2017
gpt deltaラットを用いたエレミシンの遺伝毒性評価

石井雄二, SHI Liang, 高須伸二, 木島綾希, 能美健彦, 小川久美子, 梅村隆志

Journal of Toxicological Sciences, 42(Supplement) S305, Jun, 2017
食品用途香料であるFurfural propyleneglycol acetalのF344ラットにおける90日間反復投与毒性試験

木島綾希, 石井雄二, 高須伸二, 梅村隆志, 小川久美子

日本食品化学学会総会・学術大会講演要旨集, 23rd 130, Jun 1, 2017

Professional Memberships

Research Projects

Nrf2/Notch signal pathways contributing to ON/OFF regulation in sustained livre regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Umemura Takashi
Possible involvement of Nrf2 in breakdown of liver regeneration program

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Umemura Takashi
Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2012

FUKUHARA Kiyoshi, OKUDA Haruhiro, UMEMURA Takashi, OHNO Akiko, SYODA Takuji
Design and Synthesis of Antioxidant for a New Type of Chemopreventive Agents

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2007

KIYUOSHI Fukuhara, OKUDA Haruhiro, UMEMURA takashi, SHODA Takuji
Studies on molecular mechanisms underlying endogenous carcinogenesis using transgenic reporter genes as internal probes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2003

NISHIKAWA Akiyoshi, KANKI Keita, UMEMURA Takashi
Construction of mouse embryonic stem cells for the detection of gene mutation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1996 - 1998

INOUE Tohru, SAGA Yumiko, HIRABAYASHI Yoko, TAKAGI Atsuya
Signal transduction mediated by hematopoietic factors and TGF-β in p53-deficient mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1996 - 1998

INOUE Tohru, HIRABAYASHI Yoko, TAKAGI Atsuya, HIROSE Akihiko, SASAKI Hideki
薬剤評価モデルとしてのヒト型造血因子受容体遺伝子導入マウスとその造血幹細胞動態制御

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

井上達, 梅村隆志, 高木篤也, 横田崇, 平林容子
遺伝子改変動物の造血幹細胞動態制御を指標としたサイトカイン系薬剤評価モデルの開発

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1996 - 1996

井上達, 梅村隆志, 高木篤也, 横田崇, 平林容子

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