寒川賢治 (KANGAWA KENJI) - マイポータル

基本情報

所属: 国立研究開発法人国立循環器病研究センター名誉研究所長

学位: 理学博士

J-GLOBAL ID: 200901088464119097
researchmap会員ID: 0000041274

研究分野

ライフサイエンス / 代謝、内分泌学 /

受賞

日本内分泌学会川上賞 (1985年)
日本生化学会奨励賞 (1985年)
The Kawakami Memorial Prize (Japanese Society Endcrinology)
The Prize Encouragement of research (Japanese Society of Biochemistry) (1985)
日本肥満学会賞(2016年)

寒川賢治
慶應医学賞(2009年)

寒川賢治
日本学士院賞(2008年)

寒川賢治

論文

750

A chemically stable peptide agonist to neuromedin U receptor type 2.

Kentaro Takayama, Kenji Mori, Akiko Tanaka, Yu Sasaki, Yuko Sohma, Akihiro Taguchi, Atsuhiko Taniguchi, Toshiyasu Sakane, Akira Yamamoto, Mikiya Miyazato, Naoto Minamino, Kenji Kangawa, Yoshio Hayashi

Bioorganic & medicinal chemistry 28(10) 115454-115454 2020年5月15日
Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system

Madoka Anan, Ryoko Higa, Kenshiro Shikano, Masahito Shide, Akinobu Soda, Magdeline E. Carrasco Apolinario, Kenji Mori, Toshitaka Shin, Mikiya Miyazato, Hiromitsu Mimata, Takatoshi Hikida, Toshikatsu Hanada, Kazuwa Nakao, Kenji Kangawa, Reiko Hanada

Heliyon 6(5) e03947-e03947 2020年5月査読有り
Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure.

Takekazu Miyoshi, Takashi Hisamitsu, Hatsue Ishibashi-Ueda, Kenji Ikemura, Tomoaki Ikeda, Mikiya Miyazato, Kenji Kangawa, Yusuke Watanabe, Osamu Nakagawa, Hiroshi Hosoda

International journal of cardiology 302 110-116 2020年3月1日査読有り
Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.

Keiko Nakahara, Keisuke Maruyama, Takuya Ensho, Kenji Mori, Mikiya Miyazato, Kenji Kangawa, Ryoko Uemura, Hideyuki Sakoda, Masamitsu Nakazato, Noboru Murakami

Biochemical and biophysical research communications 521(2) 521-526 2020年1月8日
Plasma desacyl ghrelin-to-acyl ghrelin ratio is a predictor of postoperative complications and prognosis after pancreaticoduodenectomy.

Takahiro Nishida, Hironobu Tsubouchi, Takeomi Hamada, Naoya Imamura, Masahide Hiyoshi, Koichi Yano, Kenji Kangawa, Masamitsu Nakazato, Atsushi Nanashima

Oncology letters 18(5) 4974-4983 2019年11月査読有り
Plasma natriuretic peptide levels reflect the status of the heart failure in fetuses with arrhythmia.

Takekazu Miyoshi, Hiroshi Hosoda, Ken-Ichi Kurosaki, Isao Shiraishi, Michikazu Nakai, Kunihiro Nishimura, Mikiya Miyazato, Kenji Kangawa, Jun Yoshimatsu, Naoto Minamino

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 34(12) 1-7 2019年8月15日
ニューロメジンS前駆体中の新規ペプチド(NSRP)の生理機能の探索

田口史門, 延生卓也, 森健二, 宮里幹也, 寒川賢治, 丸山圭介, 村上昇, 中原桂子

日本獣医学会学術集会講演要旨集 162回 483-483 2019年8月
Metabolism of atrial and brain natriuretic peptides in the fetoplacental circulation of fetuses with congenital heart diseases.

T. Miyoshi, H. Hosoda, M. Miyazato, K. Kangawa, J. Yoshimatsu, N. Minamino

Placenta 83 26-32 2019年8月査読有り
Plasma desacyl ghrelin-to-acyl ghrelin ratio is a predictor of postoperative complications and prognosis after pancreaticoduodenectomy

Takahiro Nishida, Hironobu Tsubouchi, Takeomi Hamada, Naoya Imamura, Masahide Hiyoshi, Koichi Yano, Kenji Kangawa, Masamitsu Nakazato, Atsushi Nanashima

Oncology Letters 18(5) 4974-4983 2019年査読有り
Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias.

Miyoshi T, Hosoda H, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N

American journal of obstetrics and gynecology 220(1) 104.e1-104.e15 2018年9月査読有り
Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias.

Miyoshi T, Hosoda H, Umekawa T, Asada T, Fujiwara A, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N

Circulation journal : official journal of the Japanese Circulation Society 82(10) 2619-2626 2018年9月査読有り
Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models.

Hiroaki Kitamura, Daisuke Nakano, Yoshiharu Sawanobori, Takehiko Asaga, Hideki Yokoi, Motoko Yanagita, Masashi Mukoyama, Takeshi Tokudome, Kenji Kangawa, Gotaro Shirakami, Akira Nishiyama

Anesthesiology 129(2) 296-310 2018年8月査読有り
Corrigendum to 'Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury' [Pulm. Pharmacol. Therapeut. 29/1 (2014) 24-30].

Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Kimura T, Shintani Y, Inoue M, Sawabata N, Miyazato M, Okumura M, Kangawa K

Pulmonary pharmacology & therapeutics 51 79-81 2018年8月査読有り
C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis

Bae CR, HINO J, Hosoda H, Miyazato M, Kangawa K

Life Sciences 209 349-356 2018年8月査読有り
Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure

Hiroyuki Takahama, Seiji Takashio, Toshio Nishikimi, Tomohiro Hayashi, Chiaki Nagai-Okatani, Yasuaki Nakagawa, Makoto Amaki, Takahiro Ohara, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Satoshi Yasuda, Kenji Kangawa, Naoto Minamino, Toshihisa Anzai

International Journal of Cardiology 258 165-171 2018年5月1日査読有り
Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet.

Cho-Rong Bae, Jun Hino, Hiroshi Hosoda, Cheol Son, Hisashi Makino, Takeshi Tokudome, Tsutomu Tomita, Kiminori Hosoda, Mikiya Miyazato, Kenji Kangawa

Scientific reports 8(1) 2093-2093 2018年2月1日査読有り
CORRIGENDUM: Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias.

Takekazu Miyoshi, Hiroshi Hosoda, Takashi Umekawa, Takashi Asada, Akihiro Fujiwara, Ken-Ichi Kurosaki, Isao Shiraishi, Michikazu Nakai, Kunihiro Nishimura, Mikiya Miyazato, Kenji Kangawa, Tomoaki Ikeda, Jun Yoshimatsu, Naoto Minamino

Circulation journal : official journal of the Japanese Circulation Society 82(12) 3112-3112 2018年
Effectiveness of nationwide screening and lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan: The metabolic syndrome and comprehensive lifestyle intervention study on nationwide database in Japan (MetS ACTION-J study).

Yoko M Nakao, Yoshihiro Miyamoto, Kenji Ueshima, Kazuhiro Nakao, Michikazu Nakai, Kunihiro Nishimura, Shinji Yasuno, Kiminori Hosoda, Yoshihiro Ogawa, Hiroshi Itoh, Hisao Ogawa, Kenji Kangawa, Kazuwa Nakao

PloS one 13(1) e0190862 2018年査読有り
Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice

Hitoshi Teranishi, Masafumi Hayashi, Ryoko Higa, Kenji Mori, Takashi Miyazawa, Jun Hino, Yuichiro Amano, Ryuichi Tozawa, Takanori Ida, Toshikatsu Hanada, Mikiya Miyazato, Reiko Hanada, Kenji Kangawa, Kazuwa Nakao

Peptides 99 134-141 2018年1月1日査読有り
Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.

Sayaka Akieda-Asai, Takanori Ida, Mikiya Miyazato, Kenji Kangawa, Yukari Date

Peptides 99 14-19 2018年1月査読有り

もっとみる

MISC

血管内皮細胞由来C型ナトリウム利尿ペプチド(CNP)は腎臓疾患による腎線維化を抑制する

延生卓也, 日野純, 白井学, 細田洋司, 森健二, 南野直人, 宮里幹也, 寒川賢治

日本内分泌学会雑誌 96(1) 2020年
The Homeostatic Force of Ghrelin

Shigehisa Yanagi, Takahiro Sato, Kenji Kangawa, Masamitsu Nakazato

Cell Metabolism 27(4) 786-804 2018年4月3日
Three molecular forms of atrial natriuretic peptides: quantitative analysis and biological characterization

Chiaki Nagai-Okatani, Kenji Kangawa, Naoto Minamino

Journal of Peptide Science 23(7-8) 486-495 2017年7月1日
Hydrodynamic法を用いたニューロメジンU過剰発現マウスにおけるエネルギー代謝調節機構

寺西仁志, 花田礼子, 寒川賢治, 中尾一和

日本内分泌学会雑誌 93(1) 331-331 2017年4月
The regulation of circulating ghrelin – With recent updates from cell-based assays

Hiroshi Iwakura, Kenji Kangawa, Kazuwa Nakao

Endocrine Journal 62(2) 107-122 2015年
Physiological roles of ghrelin on obesity

Takahiro Sato, Takanori Ida, Yuki Nakamura, Yuki Shiimura, Kenji Kangawa, Masayasu Kojima

Obesity Research and Clinical Practice 8(5) e405-e413 2014年9月1日
Ghrelin/ghrelin receptors

Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato

JOURNAL OF MOLECULAR ENDOCRINOLOGY 52(3) T87-T100 2014年6月
Reduction in circulating ghrelin concentration after maturation does not affect food intake

Hiroyuki Ariyasu, Go Yamada, Hiroshi Iwakura, Sigenobu Matsumura, Kazuo Inoue, Kenji Kangawa, Kazuwa Nakao, Takashi Akamizu

Endocrine Journal 61(10) 1041-1052 2014年
哺乳類と魚類におけるデカン酸修飾型グレリン免疫活性量の比較

西芳寛, 御船弘治, 海谷啓之, 細田洋司, 平田留美子, 佐藤元康, 杉本博之, 田中永一郎, 寒川賢治, 児島将康

日本内分泌学会雑誌 89(2) 591-591 2013年9月
末梢におけるニューロメジンUシステムのNAFLD/NASHへの関与

寺西仁志, Stanojevic Boban, 天野雄一郎, 兎澤隆一, 森健二, 日野純, 宮澤崇, 宮里幹也, 花田礼子, 寒川賢治, 中尾一和

肥満研究 19(Suppl.) 179-179 2013年9月
Adrenomedullin in cardiovascular disease: A useful biomarker, its pathological roles and therapeutic application

Toshio Nishikimi, Koichiro Kuwahara, Yasuaki Nakagawa, Kenji Kangawa, Kazuwa Nakao

Current Protein and Peptide Science 14(4) 256-267 2013年
Ghrelin as a starvation signal

Yukari Date, Kenji Kangawa

Obesity Research and Clinical Practice 6(4) e263-e269 2012年10月
The physiological significance and potential clinical applications of ghrelin

Takashi Akamizu, Kenji Kangawa

European Journal of Internal Medicine 23(3) 197-202 2012年4月
Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect

Takashi Akamizu, Kenji Kangawa

Peptides 32(11) 2295-2300 2011年11月
モノクロタリン肺高血圧ラットの肺微小循環調節におけるRho-kinaseシグナル及び内皮機能の役割

白井幹康, シュエンキ・ダリル, 曽野部崇, 藤井豊, 吉本光佐, 寒川賢治, 梅谷啓二

日本内分泌学会雑誌 87(2) 784-784 2011年9月
Natriuretic peptide system: An overview of studies using genetically engineered animal models

Ichiro Kishimoto, Takeshi Tokudome, Kazuwa Nakao, Kenji Kangawa

FEBS Journal 278(11) 1830-1841 2011年6月
Two ghrelin receptors in goldfish

Hiroyuki Kaiya, Tohru Miura, Kouhei Matsuda, Mikiya Miyazato, Kenji Kangawa

ENDOCRINE JOURNAL 57 S625-S625 2010年3月
Identification of bioactive peptides associated with the metabolic syndrome

Takashi Miyazawa, Mikiya Miyazato, Morikatsu Yoshida, Kazutomo Sawai, Kenji Mori, Kenji Kangawa

ENDOCRINE JOURNAL 57 S435-S436 2010年3月
Bone morphogenetic protein-3b (BMP-3b) is an adipocytokine secreted from preadipocytes and inhibits their differentiation

Jun Hino, Takashi Mlyazawa, Mikiya Miyazato, Kenji Kangawa

ENDOCRINE JOURNAL 57 S407-S407 2010年3月
Ghrelin and functional dyspepsia

Takashi Akamizu, Hiroshi Iwakura, Hiroyuki Ariyasu, Kenji Kangawa

International Journal of Peptides 2010 2010年

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寒川賢治

基本情報

研究分野

受賞

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

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