J-GLOBAL         Last updated: Jul 11, 2019 at 09:54
National Cerebral and Cardiovascular Center
Omics Research Center
Job title
Ph.D.(Osaka University)

Research Areas


Academic & Professional Experience

Apr 2019
Research Director, Omics Research Center, Open Innovation Center, National Cerebral and Cardiovascular Center
Apr 2015
Mar 2019
Director, Omics Research Center, National Cerebral and Cardiovascular Center


Department of Chemistry, Faculty of Science, Osaka University

Committee Memberships

The Japanese Peptide Society  (Member of the Board)
The Japanese Biochemical Society  (Member of the Board)
The Endocrine Society (U.S.A)  (Member)
The Japan Endocrine Society  (Member of the Board)
Protein Science Society of Japan  (Member)

Awards & Honors

Nov 2015
The Japan Peptide Society Award 2015
The Young Investigator Award, The Japanese Biochemical Society (1989)

Published Papers

Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias.
T. Miyoshi, H. Hosoda, M. Nakai, K. Nishimura, M. Miyazato, K. Kangawa, T. Ikeda, J. Yoshimatsu, N. Minamino
Am J Obstet Gynecol.   220(1) 104.e1-104.e15   Jan 2019   [Refereed]
Plasma soluble neprilysin levels are unchanged during recovery after decompensation of heart failure: a matter of the magnitude of the changes in systemic haemodynamics?
H. Takahama, N. Minamino, C. Izumi
Eur Heart J.   39(37) 3472-3473   Oct 2018   [Refereed]
Plasma natriuretic peptide levels in fetuses with congenital heart defect and arrhythmia: a single-center prospective study.
T. Miyoshi, T. Umekawa, H. Hosoda, T. Asada, A. Fujiwara, K.I. Kurosaki, I. Shiraishi, M. Nakai, K. Nishimura, M. Miyazato, K. Kangawa, T. Ikeda, J. Yoshimatsu, and N. Minamino
Ultrasound Obstet. Gynecol.   52 609-616   Oct 2018   [Refereed]
Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias.
T. Miyoshi, H. Hosoda, T. Umekawa, T. Asada, A. Fujiwara, K.I. Kurosaki, I. Shiraishi, M. Nakai, K. Nishimura, M. Miyazato, K. Kangawa, T. Ikeda, J. Yoshimatsu, N. Minamino
Circ. J.   82(10) 2619-2626   Sep 2018   [Refereed]
Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure
H. Takahama, S. Takashio, T. Nishikimi, T. Hayashi, C. Nagai-Okatani, Y. Nakagawa, M. Amaki, T. Ohara, T. Hasegawa, Y. Sugano, H. Kanzaki, S. Yasuda, K. Kangawa, N. Minamino, T. Anza
Int. J. Cardiol.   258 165-171   May 2018   [Refereed]
A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.
T. Miyazaki, K. Otani, A. Chiba, H. Nishimura, T. Tokudome, H. Watanabe-Takano, A. Matsuo, H. Ishikawa, K. Shimamoto, H. Fukui, Y. Kanai, A. Yasoda, S. Ogata, K. Nishimura, N. Minamino, and N. Mochizuki
Circ Res.   122(5) 742-751   Mar 2018   [Refereed]
Geniposidic acid upregulates atrial natriuretic peptide secretion and lowers blood pressure in spontaneously hypertensive rat
K. Nakamura, S. Hosoo, S. Yamaguchi, M. Koyama, R. Yamazaki, T. Hirata, Y. Yamaguchi, H. Yamasaki, N. Minamino, K. Wada, S. Nishibe
J. Funct. Foods   40 634-658   Jan 2018   [Refereed]
Natriuretic peptides in human heart: Novel insight into their molecular forms, functions, and diagnostic use
A. Matsuo, C. Nagai-Okatani, M. Nishigori, K. Kangawa, N. Minamino
Peptides   111 3-17   Jan 2018   [Refereed]
The effect of circulating osteocrin on endochondral bone growth.
Y. Kanai, A. Yasoda, K.P. Mori, H. Watanabe-Takano, C. Nagai-Okatani, Y. Yamashita, K. Hirota, Y. Ueda, I. Yamauchi, E. Kondo, S. Yamanaka, Y. Sakane, K. Nakao
J Clin Invest.   127(11) 4136-4147   Nov 2017   [Refereed]
Endogenous peptide profile for elucidating biosynthetic processing of the ghrelin precursor.
T. Tsuchiya, H. Iwakura, N. Minamino, K. Kangawa, and K. Sasaki
Biochem. Biophys. Res. Commun.   490(4) 1142-1146   Sep 2017   [Refereed]

Research Grants & Projects

Construction of Peptidome database, the comprehensive factdatabase for endogenous peptides
Special Coordination Funds for Promoting Science and Technology
Project Year: 1999 - 2004
By analyzing peptides in the target cells, tissues and organisms with HPLC and mass spectrometry, data sets of the peptides in the target are registered in the databse based on their physiocochemical properties. The database thus constructed can ...
Proteins and peptides regulating the cardiovascular system: Their application to cardiovascular disease
Basic Research Promotion Service for Health and Medical Field
Project Year: 2004 - 2008
Systematic survey for disease-related biomarkers for drug discovery, diagnosis and prognosis
Health and Labour Sciences Research Grants
Project Year: 2008 - 2012
Analysis of tissue-specific processing and generating system of peptides by the peptidomic procedures
Grant-in-Aid for Scientific Research
Project Year: 2006 - 2008