We have developed an ultra-durable heparin-free ECMO system with an innovative compact leakless oxygenators and a novel heparin bonding material. The system was evaluated in a series of venoarterial bypass heparin-free ECMO animal experiments using 22 goats. The system could be perfused for over one month (up to three months) successfully. We conclude that our ECMO systems can be applied to wider variety of patients with active bleeding and those with a need of prolonged support.