Yoshinori Murakami

Profile Information

Affiliation: Professor, The Institute of Medical Science, Division of Molecular Pathology, The University of Tokyo

Degree: M.D. & Ph.D.

J-GLOBAL ID: 200901072697152899
researchmap Member ID: 0000041772

External link: http://www.ims.u-tokyo.ac.jp/hitogan/index.html

Research Interests

Research Areas

Life sciences / Tumor diagnostics and therapeutics /

Research History

2007 - Present

Professor, Division of MolecularPathology, The Institute of Medical Science, The University of Tokyo
Jul, 2000 - Mar, 2007

プロジェクトリーダー, がん抑制ゲノム研究プロジェクト, 国立がんセンター研究所
1994 - 2000

国立がんセンター研究所腫瘍遺伝子研究部室長
1994 - 2000

Section Head, Oncogene Division,
1992 - 1994

米国ユタ大学ハワード・ヒューズ研究所研究員
1992 - 1994

Research Associate,
1985 - 1994

国立がんセンター研究所腫瘍遺伝子研究部研究員
1985 - 1994

Research Associate,
1983 - 1985

東京大学医学部附属病院内科研修医
1983 - 1985

Junior Clinical Resident of Internal Medicine,
がん抑制ゲノム研究プロジェクト室長
National Cancer Center Research Institute
Tumor Suppression & Functional Genomics Project,
National Cancer Center Res. Inst.
Howard Hughes Medical Inst. University of Utah, USA
Oncogene Division National Cancer Center Res. Inst.
University of Tokyo, School of Medicine

Education

Awards

Feb, 2013

Academic Award, Princess Takamatsu Cancer Research Fund

Yoshinori Murakami
1998 日本癌学会、奨励賞
1992 日本肝臓学会、研究奨励賞
the Japanese Cancer Association
1998 Incitement Award of
the Japanese Hematological Society
1992 Incitement Award of

Papers

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis

Go Sato, Yuya Shirai, Shinichi Namba, Ryuya Edahiro, Kyuto Sonehara, Tsuyoshi Hata, Mamoru Uemura, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki …

Nature Communications, 14(1), Dec, 2023
Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis

Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki …

Cell Reports Medicine, 4(7), Jul 18, 2023
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

Shohei Kojima, Satoshi Koyama, Mirei Ka, Yuka Saito, Erica H. Parrish, Mikiko Endo, Sadaaki Takata, Misaki Mizukoshi, Keiko Hikino, Atsushi Takeda …

Nature Genetics, May 11, 2023 Peer-reviewed
Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals

Masato Akiyama, Saori Sakaue, Atsushi Takahashi, Kazuyoshi Ishigaki, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Yukinori Okada, Toshiharu Ninomiya, Masaru Koido …

Communications Biology, 6(1), Feb 3, 2023
Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, Zhaonan Zou, Masayuki Kubota, Seitaro Nomura, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Masato Akiyama …

Nature Genetics, 55(2) 187-197, Jan 19, 2023
Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk.

Yoshiaki Usui, Yusuke Iwasaki, Keitaro Matsuo, Mikiko Endo, Yoichiro Kamatani, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Koichi Matsuda, Yoshinori Murakami …

Cancer science, 113(11) 3972-3979, Sep 5, 2022
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.

Shweta Ramdas, Jonathan Judd, Sarah E Graham, Stavroula Kanoni, Yuxuan Wang, Ida Surakka, Brandon Wenz, Shoa L Clarke, Alessandra Chesi, Andrew Wells …

American journal of human genetics, 109(8) 1366-1387, Aug 4, 2022
Different risk genes contribute to clear cell and non-clear cell renal cell carcinoma in 1532 Japanese patients and 5996 controls.

Yuya Sekine, Yusuke Iwasaki, Tomomi Aoi, Mikiko Endo, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami …

Human molecular genetics, 31(12) 1962-1969, Jun 22, 2022
Genetic analysis of right heart structure and function in 40,000 people

James P. Pirruccello, Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Samuel F. Friedman, Marcus D.R. Klarqvist, Mark D. Chaffin, Lu Chen Weng, Jonathan W. Cunningham, Shaan Khurshid …

Nature Genetics, 54(6) 792-803, Jun, 2022
Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.

Yukihide Momozawa, Rumi Sasai, Yoshiaki Usui, Kouya Shiraishi, Yusuke Iwasaki, Yukari Taniyama, Michael T Parsons, Keijiro Mizukami, Yuya Sekine, Makoto Hirata …

JAMA oncology, 8(6) 871-878, Jun 1, 2022
Trans-homophilic interaction of CADM1 promotes organ infiltration of T-cell lymphoma by adhesion to vascular endothelium.

Yutaka Kasai, Siew Pey Gan, Toko Funaki, Yuki Ohashi-Kumagai, Mizuki Tominaga, Shu-Jen Shiu, Daisuke Suzuki, Daisuke Matsubara, Takeharu Sakamoto, Mika Sakurai-Yageta …

Cancer science, 113(5) 1669-1678, May, 2022
Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer

Keiko Hikino, Masaru Koido, Nao Otomo, Kohei Tomizuka, Shiro Ikegawa, Koichi Matsuda, Yukihide Momozawa, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki …

Journal of Human Genetics, 67(3) 149-156, Mar, 2022
[Cohorts and Biobanks as Essential Resources for Cancer Research].

Yoshinori Murakami

Gan to kagaku ryoho. Cancer & chemotherapy, 49(2) 129-132, Feb, 2022
Usefulness of circulating tumor DNA by targeting human papilloma virus-derived sequences as a biomarker in p16-positive oropharyngeal cancer.

Ken Akashi, Toshihiko Sakai, Osamu Fukuoka, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Takeshi Ito, Yoshinori Murakami, Tatsuya Yamasoba

Scientific reports, 12(1) 572-572, Jan 12, 2022
Circulating Tumor DNA Harboring the BRAFV600E Mutation May Predict Poor Outcomes of Primary Papillary Thyroid Cancer Patients.

Ayaka Sato, Masahiko Tanabe, Yumi Tsuboi, Takayoshi Niwa, Aya Shinozaki-Ushiku, Yasuyuki Seto, Yoshinori Murakami

Thyroid : official journal of the American Thyroid Association, 31(12) 1822-1828, Dec, 2021
The power of genetic diversity in genome-wide association studies of lipids.

Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W Winkler …

Nature, 600(7890) 675-679, Dec, 2021
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock.

Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-Ichiro Inoue …

Communications biology, 4(1) 1165-1165, Oct 7, 2021
A cross-population atlas of genetic associations for 220 human phenotypes.

Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama …

Nature genetics, 53(10) 1415-1424, Oct, 2021
Trans-ancestry genome-wide analysis of atrial fibrillation provides new insights into disease biology and enables polygenic prediction of cardioembolic risk

Kazuo Miyazawa, Kaoru Ito, Zhaonan Zou, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Seitaro Nomura, Masato Akiyama, Ryo Kurosawa, Hiroki Yoshida …

Sep 12, 2021
Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias.

Keiko Hikino, Masaru Koido, Kohei Tomizuka, Xiaoxi Liu, Yukihide Momozawa, Takayuki Morisaki, Yoshinori Murakami, The Biobank Japan Project, Taisei Mushiroda, Chikashi Terao

EBioMedicine, 70 103532-103532, Aug, 2021

Misc.

145

BRAF V600E変異をもつ甲状腺乳頭癌においてctDNA検出は予後予測因子となる可能性がある

佐藤綾花, 田辺真彦, 坪井裕見, 牛久綾, 瀬戸泰之, 村上善則

日本癌学会総会記事, 80回 [P15-6], Sep, 2021
腎細胞がんの組織型によって寄与する遺伝子が異なることを示した大規模ゲノム解析

関根悠哉, 平田真, 松田浩一, 菅野康吉, 吉田輝彦, 村上善則, 福井智洋, 赤松秀輔, 小川修, 中川英刀 …

日本癌学会総会記事, 80回 [J7-1], Sep, 2021
Novel mechanisms of EGFR-TKI resistance and clonal evolution of lung adenocarcinoma by overexpression of a cell adhesion molecule, CADM1.

Takehiro Tsuchiya, Hideki Kuwano, Takeshi Ito, Masayoshi Nagata, Taketo Kawai, Yumi Tsuboi, Daisuke Matsubara, Isami Okamoto, Kenji Tamura, Jun Nakajima …

CANCER RESEARCH, 80(21), Nov, 2020
バイオバンキングが切り拓く新しいがん研究がんのプレシジョン・メディシンに必須の研究基盤、バイオバンク・ジャパン(Innovative cancer research based on biobanking Biobank Japan, an essential resource for establishing precision medicine in the management of cancer)

村上善則, 平田真, 松田浩一

日本癌学会総会記事, 78回 S11-2, Sep, 2019
臨床情報データベースに基づくバイオバンク・ジャパン試料検索システムの構築(Establishment of BioBank Japan searching system for biospecimen, based on clinical information database)

松田浩一, 平田真, 村上善則

日本癌学会総会記事, 77回 1245-1245, Sep, 2018
肺癌におけるYAP1欠如と神経内分泌分化について

松原大祐, 伊東剛, 田中一大, 石川俊平, 後藤悌, 中野智之, 土橋洋, 中島淳, 遠藤俊輔, 深山正久 …

日本癌学会総会記事, 74回 J-1219, Oct, 2015
肺腺がん細胞の実験的転移系を用いた転移関連分子の同定と機能解析

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳[八下田], 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 74回 J-1269, Oct, 2015
Trend in Stroke Incidence in Shiga, Japan, 1990-2010.

M. Nagai, Y. Kita, N. Takashima, Y. Murakami, R. D. Abbott, T. C. Turin, N. Rumana, K. Miura, H. Ueshima

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 44 152-153, 2015
Synergistic effect of the combination of mass media and distribution media on improvement of knowledge about early stroke symptoms

N. Miyamatsu, A. Morino, K. Miura, K. Godai, A. Morimoto, Y. Murakami, N. Takashima, Y. Kita, K. Nozaki

INTERNATIONAL JOURNAL OF STROKE, 9 290-290, Oct, 2014
Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition

Daisuke Matsubara, Reem Ibrahim, Wael Osman, Akteru Goto, Teppei Morikawa, Shigeki Morita, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Toshiro Niki …

CANCER RESEARCH, 74(19), Oct, 2014
肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳[八下田], 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 73回 P-3133, Sep, 2014
膀胱癌における細胞接着分子CADM1の予後予測因子としての意義

川合剛人, 後藤明輝, 永田政義, 岩井美和子, 森川鉄平, 久米春喜, 深山正久, 本間之夫, 村上善則

日本癌治療学会誌, 48(3) 1617-1617, Sep, 2013
乳癌におけるCADM遺伝子発現とその役割の検討

斎藤元伸, 松嵜正實, 伊藤泰輔, 佐久間威之, 片方直人, 渡辺文明, 後藤明輝, 村上善則, 竹之下誠一, 野水整

日本乳癌学会総会プログラム抄録集, 21回 359-359, Jun, 2013
Attitude to an Ambulance Call and Knowledge About Early Symptoms of Stroke Among Japanese General Population

N. Miyamatsu, K. Nozaki, K. Miura, A. Morino, A. Morimoto, R. Katayose, K. Godai, N. Sonoda, Y. Murakami, Y. Kita …

CEREBROVASCULAR DISEASES, 36 46-46, 2013
Relationship Between Knowledge of Early Stroke Symptoms and Planned Response to Each Symptom Among a General Japanese Population

A. Morimoto, N. Miyamatsu, K. Nozaki, K. Miura, A. Morino, R. Katayose, K. Godai, N. Sonoda, Y. Murakami, Y. Kita …

CEREBROVASCULAR DISEASES, 36 47-47, 2013
HYPERTENSION AND DISABILITY-FREE LIFE EXPECTANCY FROM A COHORT STUDY IN JAPAN -RESULTS FROM A NATIONWIDE COHORT STUDY (NIPPON DATA80/90)

Y. Murakami, T. Hayakawa, K. Miura, T. Ohkubo, Y. Kita, N. Takashima, A. Fujiyoshi, T. Okamura, A. Okayama, H. Ueshima

VALUE IN HEALTH, 15(7) A384-A384, Nov, 2012
膀胱癌における細胞接着分子CADM1の異常とその意義

川合剛人, 後藤明輝, 永田政義, 岩井美和子, 森川鉄平, 久米春喜, 深山正久, 本間之夫, 村上善則

日本癌治療学会誌, 47(3) 2622-2622, Oct, 2012
肺腺がんのEGFR-TK阻害剤に対する耐性獲得における細胞接着分子CADM1の役割(Possible involvement of a cell adhesion molecule, CADM1 in acquired resistance of lung adenocarcinoma to EGFR-TKIs)

桑野秀規, 岩井美和子, 川合剛人, 伊東剛, 桜井美佳[八下田], 後藤明輝, 小泉史明, 中島淳, 田村研治, 村上善則

日本癌学会総会記事, 71回 442-442, Aug, 2012
肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳[八下田], 後藤明輝, 村上善則

日本癌学会総会記事, 71回 487-487, Aug, 2012
膀胱癌における細胞接着分子CADM1の異常とその意義

川合剛人, 後藤明輝, 永田政義, 岩井美和子, 森川鉄平, 森田茂樹, 久米春喜, 深山正久, 本間之夫, 村上善則

日本泌尿器科学会雑誌, 103(2) 488-488, Mar, 2012

Professional Memberships

Research Projects

Platform of Supporting Cohort Study and Biospecimen Analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2028
生命科学連携推進協議会

科学研究費助成事業, 学術変革領域研究(学術研究支援基盤形成), 日本学術振興会, Apr, 2022 - Mar, 2028

武川睦寛, 黒川顕, 鍋倉淳一, 村上善則, 山梨裕司, 阿形清和, 井上純一郎, 中村卓郎, 高田昌彦, 清宮啓之, 根本知己, 上野直人, 若井建志, 村山繁雄, 醍醐弥太郎, 加藤和人
Elucidation of mechanisms of carcinogenesis, metastasis, and metabolism based on histological characteristics of HNF4alpha-positive lung adenocarcinoma

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Development of novel diagnostic and therapeutic approaches to cancer by analyzing specific features of the immunoglobulin superfamily of molecules.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024
Development of novel intervening approaches to cancer progression by comprehensive analyses of interactions between cell adhesion molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Murakami Yoshinori
生命科学連携推進協議会

科学研究費助成事業, 新学術領域研究（研究領域提案型）『学術研究支援基盤形成』, 日本学術振興会, 2016 - 2021

井上純一郎, 今井浩三, 小原雄治, 狩野方伸, 井本敬二, 山本正幸, 上野直人, 鍋倉淳一, 中村卓郎, 井上純一郎, 高田昌彦, 若井建志, 村上善則, 村山繁雄, 加藤和人, 田中英夫
コホート・生体試料支援プラットフォーム

科学研究費助成事業, 新学術領域研究（研究領域提案型）『学術研究支援基盤形成』, 日本学術振興会, 2016 - 2021

村上善則, 今井浩三, 若井建志, 村上善則, 松尾恵太郎, 三上春夫, 鈴木貞夫, 喜多義邦, 渡辺能行, 田中恵太郎, 嶽崎俊郎, 栗木清典, 古庄憲浩, 有澤孝吉, 玉腰暁子, 今田恒夫, 武林亨, 三浦克之, 成松宏人, 鈴木康司, 村山繁雄, 高尾昌樹, 赤津裕康, 齊藤祐子, 矢部博興, 中杤昌弘, 清水厚志, 醍醐弥太郎, 高橋隆, 宮城洋平, 渡邉俊樹, 安井寛, 田中英夫, 内藤真理子, 大中佳三, 森満, 川崎良
細胞膜分子動態数理モデリングによるがん悪性化メカニズムの解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Jul, 2015 - Mar, 2017

鈴木貴, 川崎秀二, 村上善則, 越川直彦
Analysis of somatic alteration of copy number variation in cancer as a new instability of cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

MURAKAMI Yoshinori
Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

MURAKAMI Yoshinori
細胞接着分子群の解析に基づく、がんの個性診断法の開発

科学研究費補助金, 2010 - 2013
Molecular understanding and diagnosis of human cancer through the structural, functional and expression analysis of cancer related genes.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

MURAKAMI Yoshinori, MASUDA Mari, ITO Akihiko, SAKURAI Mika
Analysis of pathological significance of a cell adhesion molecule TSLC1 in male infertility and in ulcerative colitis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

MURAKAMI Yoshinori, TAKEUCHI Takumi
Cancer Genetics Structural and Functional Analysis of Tumor Suppressor Gene DNA Diagnosis of Cancer

Industrial Property Rights

遺伝子異常検索法並びに遺伝子異常検索装置

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Misc.

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