論文

査読有り 国際誌
2021年8月

Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors

The International journal of artificial organs
  • Nobutomo Morita
  • ,
  • Daisuke Sakota
  • ,
  • Akiko Oota-Ishigaki
  • ,
  • Ryo Kosaka
  • ,
  • Osamu Maruyama
  • ,
  • Masahiro Nishida
  • ,
  • Kazuki Kondo
  • ,
  • Toshihiro Takeshita
  • ,
  • Wataru Iwasaki

44
8
開始ページ
565
終了ページ
573
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0391398820978656

INTRODUCTION: Real-time, non-invasive monitoring of thrombus formation in extracorporeal circuits has yet to be achieved. To address the challenges of conventional optical thrombus detection methods requiring large devices that limit detection capacity, we developed a micro-optical thrombus sensor. METHODS: The proposed micro-optical thrombus sensor can detect the intensity of light scattered by blood at wavelengths of 660 and 855 nm. Two thrombus sensors were installed on in vitro circuit: one at the rotary blood pump and one at a flow channel. To evaluate the variation in the ratio of incident light intensity at each wavelength of the two sensors, Rfluct (for 660 nm) and Ifluct (for 855 nm) were defined. Using fresh porcine blood as a working fluid, we performed in vitro tests of haematocrit (Hct) and oxygen saturation (SaO2) variation and thrombus detection. Thrombus tests were terminated after Rfluct or Ifluct showed a larger change than the maximum range of those in the Hct and SaO2 variation test. RESULTS: In all three thrombus detection tests, Ifluct showed a larger change than the maximum range of those in the Hct and SaO2 variation test. After the tests, thrombus formation was confirmed in the pump, and there was no thrombus in the flow channel. The results indicate that Ifluct is an effective parameter for identifying the presence of a thrombus. CONCLUSION: Thrombus detection in an extracorporeal circuit using the developed micro-optical sensors was successfully demonstrated in an in vitro test.

リンク情報
DOI
https://doi.org/10.1177/0391398820978656
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33300399
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366175
ID情報
  • DOI : 10.1177/0391398820978656
  • PubMed ID : 33300399
  • PubMed Central 記事ID : PMC8366175

エクスポート
BibTeX RIS