論文

査読有り
2018年1月1日

Development of a real-time and quantitative thrombus sensor for an extracorporeal centrifugal blood pump by near-infrared light

Biomedical Optics Express
  • Daisuke Sakota
  • ,
  • Tatsuki Fujiwara
  • ,
  • Katsuhiro Ohuchi
  • ,
  • Katsuyuki Kuwana
  • ,
  • Hiroyuki Yamazaki
  • ,
  • Ryo Kosaka
  • ,
  • Masahiro Nishida
  • ,
  • Tomohiro Mizuno
  • ,
  • Hirokuni Arai
  • ,
  • Osamu Maruyama

9
1
開始ページ
190
終了ページ
201
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1364/BOE.9.000190
出版者・発行元
OSA - The Optical Society

We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance for thrombus detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set in the driver unit of the pump. The incident light at the near-infrared wavelength of 810 nm was aimed at the pivot bearing, and the resulting scattered light was guided to the optical fibers. The detected signal was analyzed to obtain the thrombus formation level. As a result, real-time and quantitative monitoring of the thrombus surface area on the pivot bearing was achieved with an accuracy of 3.6 ± 2.3 mm2. In addition, the sensing method using the near-infrared light was not influenced by changes in the oxygen saturation and the hematocrit. It is expected that the developed sensor will be useful for optimal anticoagulation management for long-term extracorporeal circulation therapies.


リンク情報
DOI
https://doi.org/10.1364/BOE.9.000190
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418639300014&DestApp=WOS_CPL
URL
http://orcid.org/0000-0001-8075-2269
ID情報
  • DOI : 10.1364/BOE.9.000190
  • ISSN : 2156-7085
  • ORCIDのPut Code : 46043610
  • SCOPUS ID : 85039755657
  • Web of Science ID : WOS:000418639300014

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