論文

査読有り
2016年9月

Plasma Skimming in a Spiral Groove Bearing of a Centrifugal Blood Pump

ARTIFICIAL ORGANS
  • Tomotaka Murashige
  • ,
  • Daisuke Sakota
  • ,
  • Ryo Kosaka
  • ,
  • Masahiro Nishida
  • ,
  • Yasuo Kawaguchi
  • ,
  • Takashi Yamane
  • ,
  • Osamu Maruyama

40
9
開始ページ
856
終了ページ
866
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/aor.12799
出版者・発行元
WILEY-BLACKWELL

Plasma skimming is a phenomenon in which discharge hematocrit is lower than feed hematocrit in microvessels. Plasma skimming has been investigated at a bearing gap in a spiral groove bearing (SGB), as this has the potential to prevent hemolysis in the SGB of a blood pump. However, it is not clear whether plasma skimming occurs in a blood pump with the SGB, because the hematocrit has not been obtained. The purpose of this study is to verify plasma skimming in an SGB of a centrifugal blood pump by developing a hematocrit measurement method in an SGB. Erythrocyte observation using a high-speed microscope and a bearing gap measurement using a laser confocal displacement meter was performed five times. In these tests, bovine blood as a working fluid was diluted with autologous plasma to adjust the hematocrit to 1.0%. A resistor was adjusted to achieve a pressure head of 100 mm Hg and a flow rate of 5.0 L/min at a rotational speed of 2800 rpm. Hematocrit on the ridge region in the SGB was measured using an image analysis based on motion image of erythrocytes, mean corpuscular volume, the measured bearing gap, and a cross-sectional area of erythrocyte. Mean hematocrit on the ridge region in the SGB was linearly reduced from 0.97 to 0.07% with the decreasing mean bearing gap from 38 to 21 m when the rotational speed was changed from 2250 to 3000 rpm. A maximum plasma skimming efficiency of 93% was obtained with a gap of 21 m. In conclusion, we succeeded in measuring the hematocrit on the ridge region in the SGB of the blood pump. Hematocrit decreased on the ridge region in the SGB and plasma skimming occurred with a bearing gap of less than 30 m in the hydrodynamically levitated centrifugal blood pump.


リンク情報
DOI
https://doi.org/10.1111/aor.12799
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383675500007&DestApp=WOS_CPL
URL
http://orcid.org/0000-0001-8075-2269
ID情報
  • DOI : 10.1111/aor.12799
  • ISSN : 0160-564X
  • eISSN : 1525-1594
  • ORCIDのPut Code : 46043616
  • Web of Science ID : WOS:000383675500007

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