2011年6月
Synthesis and Evaluation of Dioleoyl Glyceric Acids Showing Antitrypsin Activity
JOURNAL OF OLEO SCIENCE
- ,
- ,
- ,
- ,
- 巻
- 60
- 号
- 6
- 開始ページ
- 327
- 終了ページ
- 331
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.5650/jos.60.327
- 出版者・発行元
- JAPAN OIL CHEMISTS SOC
Previously, Lesova et al. reported the isolation and identification of metabolite OR-1, showing antitrypsin activity, produced during fermentation by Penicillium funiculosum. The structure of OR-1 was a mixture of glyceric acid (GA), esterified with C-14-C-18 fatty acids, and oleic acid (C18:1) as the most predominant fatty acid (Folia Microbiol. 46, 21-23, 2001). In this study, dioleoyl D-GA and dioleoyl L-GA were synthesized via diesterification with oleoyl chloride, and their antitrypsin activities were evaluated using both a disk diffusion method and spectral absorption measurements. The results show that both compounds and their equivalent mixtures possess antitrypsin activities; however, their IC50 values (approximately 2 mM) are much higher than that of OR-1 (4.25 mu M), suggesting that dioleoyl GA does not play a major role in the OR-1 antitrypsin activity.
- リンク情報
- ID情報
-
- DOI : 10.5650/jos.60.327
- ISSN : 1345-8957
- eISSN : 1347-3352
- Web of Science ID : WOS:000291083900008